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Von Neuem: Valproat-haltige Arzneimittel und Schwangerschaft

10. Februar 2018 – Der Ausschuss für Risikobewertung (PRAC) der Europäischen Arzneimittelagentur (EMA) empfiehlt neue Einschränkungen, um eine Valproat-Exposition ungeborener Kinder im Mutterleib zu vermeiden; Eine

Valproat-Exposition ungeborener Kinder kann zu angeborenen Missbildungen und Entwicklungsstörungen führen.

Der PRAC untersuchte die zur Verfügung stehenden Daten und beriet sich umfassend mit Angehörigen der Heilberufe sowie Frauen und deren Kindern,

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Valproate: Verhindert denn eine Patientenkarte teratogene Schädigungen von Kindern?

14. Juli 2017 – Das deutsche Bundesinstitut für Arzneimittel und  Medizinprodukte (BfArM) hat soeben einen von den betroffenen pharmazeutischen Unternehmen verfassten Informationsbrief zur Einführung einer Patientenkarte für Arzneimittel, welche Valproat (Valproinsäaure) und verwandte Substanzen enthalten, zu Handen der Ärzte und Apotheker veröffentlicht.

Hintergrund dieses Informationsbriefes ist der Bescheid des BfArM vom 10.

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Riociguat (Adempas): Kontraindikation in PH-IIP

16. September 2016 – Riociguat (Adempas) ist ein Arzneimittel, welches zur Behandlung von zwei Formen der pulmonalen Hypertonie (PH), der chronisch thromboembolischen pulmonalen Hypertonie und der pulmonalarteriellen Hypertonie (PAH), eingesetzt wird. Der Wirkstoff Riociguat ist ein Stimulator der

löslichen Guanylatzyklase (sGC),

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Riociguat (Adempas): Kontraindikation für Patienten mit pulmonaler Hypertonie in Verbindung mit idiopathischen interstitiellen Pneumonien (PH-IIP)

06. Juli 2016 – In Übereinstimmung mit dem Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM) und der Europäischen Arzneimittel-Agentur (EMA) haben die Firmen Bayer AG und MSD Sharp & Dohme GmbH in Deutschland in einem Rote-Hand-Brief zu Riociguat (Adempas) soeben,

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Die Anwendung von Viekirax mit Exviera bei Child-Pugh-B und Child-Pugh-C Patienten kann zu fatalem Leberversagen führen

09. April 2016 – Gemäss einer sogenannten DHPC (Health Professional Communication) vom 8. April 2016 orientiert Swissmedic zusammen mit der Inhaberin der Zulassungsbewilligung (AbbVie) über ernsthafte und teilweise fatale Nebenwirkungen in einer Gruppe von Patientinnen / Patienten nach Hepatitis C CirrhosisBehandlung chronischer Hepatitis C  (CHC) mit Viekirax,

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  • Mayo researchers recommend all women with breast cancer diagnosis under age 66 be offered genetic testing February 21, 2020
    A study by researchers at Mayo Clinic published this week in the Journal of Clinical Oncology suggests that all women with a breast cancer diagnosis under the age of 66 be offered germline genetic testing to determine if they have a gene mutation known to increase the risk of developing other cancers and cancers among […]
  • Cross-talk between enzymes that read and correct recipes in the cookbook of life February 21, 2020
    DNA is the hereditary material in humans, a unique cookbook of who we are. This is where you'll find the answer as to why you have your specific eye and hair colour, or perhaps why you sunburn easily.
  • Study finds certain genetic tests not useful in predicting heart disease risk February 21, 2020
    A Polygenic Risk Score—a genetic assessment that doctors have hoped could predict coronary heart disease (CHD) in patients—has been found not to be a useful predictive biomarker for disease risk, according to a Vanderbilt study published in the Journal of the American Medical Association.
  • Major discovery in the genetics of Down syndrome February 21, 2020
    Researchers at CHU Sainte-Justine and Université de Montréal have discovered a new mechanism involved in the expression of Down syndrome, one of the main causes of intellectual disability and congenital heart defects in children. The study's findings were published today in Current Biology.
  • MicroRNA exhibit unexpected function in driving cancer February 20, 2020
    Researchers long thought that only one strand of a double-stranded microRNA can silence genes. Though recent evidence has challenged that dogma, it's unclear what the other strand does, and how the two may be involved in cancer. New research from Thomas Jefferson University has revealed that both strands of some microRNA coordinate to act on […]
  • Ethnobotanical medicine is effective against the bacterium causing Lyme disease February 21, 2020
    A preclinical in vitro study shows that selected plant-based herbal medicines, especially Ghanaian quinine and Japanese knotweed, work better than antibiotics against the bacterium that causes Lyme disease. These findings represent an important step towards the development of treatments that might be better tolerated and more effective than the current standard of care.
  • Opportunity blows for offshore wind in China February 21, 2020
    If China is to meet and exceed its Paris Climate Agreement goal by 2030, it's going to need to find a way to increase its wind capacity. Researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) and Huazhong University of Science and Technology in China, found that offshore wind could […]
  • Alcohol-induced deaths in US February 21, 2020
    National vital statistics data from 2000 to 2016 were used to examine how rates of alcohol-induced deaths (defined as those deaths due to alcohol consumption that could be avoided if alcohol weren't involved) have changed in the US and to compare the results by demographic groups including sex, race/ethnicity, age, socioeconomic status and geographic location. […]
  • The integrated catalysts can simplify pharmaceutical manufacturing February 21, 2020
    Prof. In Su Lee and his research team from POSTECH developed catalytic platforms based on metal organic frameworks.
  • Shaping the rings of molecules February 21, 2020
    Canadian chemists discover a natural process to control the shape of 'macrocycles,' molecules of large rings of atoms, for use in pharmaceuticals and electronics.
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