Blog Archives

Arzneimittel im Trinkwasser und der Umwelt

10. Juni 2018 – Es muss nicht immer am genetischen Outfit eines Individuums liegen. wenn unerklärliche gesundheitliche Beeinträchtigungen auftreten oder vorliegen. Manchmal liegen Gründe vor, an welche man niemals

denken würde.

Eine Mitteilung des Deutschen Bundesamtes für Arzneimittel und Medizinprodukte (BfArM) von heute erinnert wieder einmal an ein solches Szenario.

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Fulminante Lebertoxizität mit tödlichem Verlauf unter Zynbryta (Daclizumab)

 21. Juli 2017 – Aus einer Mitteilung der Arzneimittelkommission der Deutschen Ärzteschaft (Drug Safety Mail 2017-24 vom 17. Juli 2017) geht hervor, dass in einigen Patienten / Patientinnen unter Behandlung mit Zynbryta (Daclizumab) fulminante Lebertoxizitäten mit tödlichem Verlauf auftreten können.

Zynbryta (Daclizumab) ist ein humanisierter monoklonaler Antikörper gegen den Interleukin-2-Rezeptor (genauer: gegen die α-Kette CD25),

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Sterblichkeit und Mikrostaub: Jedes Mikrogramm ist zu viel

7. Juli 2017 – Eine soeben im New England Journal of Medicine (NEJM)  veröffentlichte grosse Studie aus den USA zeigt auf, dass auch bei niedrigen Feinstaubwerten die Sterblichkeit steigen kann.

Eine Belastung durch Feinstaub geht auch unterhalb der in den USA gesetzlich gültigen Grenzwerte mit einer erhöhten Sterblichkeit einher,

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BRCA1 und BRCA2 Genetische Tests: Angelina Jolie hat sich beide Brüste operativ entfernen lassen, um das Brustkrebsrisiko zu minimieren.

 14. Mai 2013 – Der nachfolgende Text ist heute in Spiegel Online Panorama erschienen und hier in unverändertem Wortlaut wiedergegeben. Ähnliche Texte sind heute in allen Print- und Online-Medien weltweit erschienen. Der Artikel macht auf die enorme Tragweite aufmerksam, welche genetisches Testen und die damit verbundene mögliche Offenlegung von ernsthaften gesundheitlichen Risiken für eine einzelne Person haben kann.

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  • Distinct social profile and high ASD risk, 3q29 deletion survey finds July 19, 2019
    A survey of 93 people with 3q29 deletion syndrome reveals a distinct pattern of social disability and anxiety, even without a diagnosis of autism spectrum disorder. The results were published online in Molecular Autism on July 16.
  • Study sheds light on the darker parts of our genetic heritage July 19, 2019
    More than half of our genome consists of transposons,DNA sequences that are reminiscent of ancient, extinct viruses.Transposons are normally silenced by a process known as DNA methylation, but their activation can lead to serious diseases. Very little is known about transposons but researchers in an international collaboration project have now succeeded for the first time […]
  • Molecular cause for severe multi-organ syndrome July 19, 2019
    Three unrelated families on three continents (from continental Portugal, the United States and Brazil), all with healthy ancestors, had children with a very rare multi-organ condition that causes early-onset retinal degeneration, sensorineural hearing loss, microcephaly, intellectual disability, and skeletal dysplasia with scoliosis and short stature.
  • Researchers determine epigenetic origin of docetaxel-resistant breast cancer July 19, 2019
    Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) have published a study in Molecular Cancer Research in which they identify methylation patterns associated with different subtypes of breast cancer, and a subclassification of the group of "triple negatives," a breast cancer type typically associated with poor prognosis. In addition, they identified changes in DNA methylation […]
  • Researchers report the function of reverse-twisting DNA July 19, 2019
    Normally, the two strands of the DNA double helix wind around each other in a right-handed spiral. However, there is another conformation called Z-DNA in which the strands twist to the left. The function of Z-DNA has remained a mystery since its discovery. A newly published paper unambiguously establishes that the Z-conformation is key to […]
  • Study sheds light on the darker parts of our genetic heritage July 19, 2019
    More than half of our genome consists of transposons, DNA sequences that are reminiscent of ancient, extinct viruses. Transposons are normally silenced by a process known as DNA methylation, but their activation can lead to serious diseases. Very little is known about transposons but researchers in an international collaboration project have now succeeded for the first time […]
  • Flexible user interface distribution for ubiquitous multi-device interaction July 19, 2019
    KAIST researchers have developed mobile software platform technology that allows a mobile application (app) to be executed simultaneously and more dynamically on multiple smart devices. Its high flexibility and broad applicability can help accelerate a shift from the current single-device paradigm to a multiple one, which enables users to utilize mobile apps in ways previously […]
  • Atomically precise models improve understanding of fuel cells July 19, 2019
    Simulations from researchers in Japan provide new insights into the reactions occurring in solid-oxide fuel cells by using realistic atomic-scale models of the electrode active site based on microscope observations instead of the simplified and idealized atomic structures employed in previous studies. This better understanding of how the structures in the cells affect the reactions […]
  • Predicting long-term risk of death from chest X-rays July 19, 2019
    Researchers in this study looked at whether a computing system that analyzed data from thousands of chest X-rays of smokers and nonsmokers and developed a risk score could predict long-term risk of death.
  • Ivacaftor may reduce common infections in patients with CF July 19, 2019
    Patients with cystic fibrosis who take ivacaftor appear to have fewer respiratory infections over time than those not taking the drug, according to new research published online in the Annals of the American Thoracic Society.
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