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Pembrolizumab (Keytruda): Vorkommen fataler Hautreaktionen

10. Mai 2017 – Swissmedic, das Schweizerische Heilmittelinstitut, informiert uns heute mittels eines “Dear Health Care Provider Letter” (DHPC), in Zusammenarbeit mit der Inhaberin der Marktzulassung, dass bei der Anwendung von Pembrolizumab (Keytruda) ein tödlicher Fall von Stevens-Johnson Syndrom (SJS) und ein tödlicher Fall von toxischer epidermaler Nekrolyse (TEN) aufgetreten sind.

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Gibt es eine genetische Prädisposition für schwerwiegende Hautreaktionen in asiatischen Patienten unter Phenytoin- oder Fosphenytoin-Therapie?

26. März 2009 – Die amerikanische Food and Drug Administration (FDA) hat Anfangs März 2009 angekündigt, dass sie preliminäre Daten untersucht welche auf ein drastisch erhöhtes Risiko für schwerwiegende Hauterkrankungen in Patienten hindeuten, welche aus Asien stammen, das Leukozyten-Antigen HLA-B*1502 tragen, und sich in anti-epileptischer Therapie mit Arzneimitteln befinden,

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Erlotinib [Tarceva]: Erhöhtes Risiko für gastrointestinale Perforation, bullose und exfoliative Hautveränderungen einschliesslich sehr seltener Verdachtsfälle von Stevens-Johnson-Syndrom (SJS) und Toxischer Epidermaler Nekrolyse (TEN), und okulare Störungen

17. April 2008 – Gemäss einer Mitteilung der Swissmedic hat Roche Pharma (Schweiz), in Zusammenarbeit mit Swissmedic, am 15. April 2009 über neue wichtige sicherheitsrelevante Informationen und die Aktualisierung des Sicherheitsprofils von Erlotinib [Tarceva] informiert. Danach sind dringend folgende Warnhinweise und Vorsichtsmassnahmen neu zu beachten:

Gastrointestinale Perforation:  0.1 –

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Informationen über das Auftreten von Magen-Darm-Perforationen im Zusammenhang mit der Anwendung von Erlotinib [Tarceva]

25. Mai 2009 – Das Deutsche Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM) bittet in einer Mitteilung von heute dringend um die Beachtung der aktualisierten Warnhinweise und Vorsichtsmassnahmen in der Fachinformation zu Erlotinib [Tarceva]. Zu den aktuellen Änderungen wird ein Rote-Hand-Brief zu Tarceva versendet.

Zusammengefasst wird dabei festgehalten:

1.

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Seltene, jedoch schwerwiegende Hauterkrankungen mit Isotretinoin [Roaccutan]

16. Februar 2010 – Wir lernen heute aus einer aktuellen Mitteilung der Swissmedic, dass Roche Pharma (Schweiz) AG in einer direkten Mitteilung an Medizinalpersonen in der Schweiz über das Auftreten schwerwiegender Hauterkrankungen in Personen welche mit Isotretinoin [Roaccutan] therapiert werden, informiert. Der Author dieses Blogs findet, dass diese Information auch dem betroffenen Patienten frei zugänglich sein sollte.

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  • The co-occurrence of cancer driver genes, key to precision medicine September 22, 2020
    Cancer driver genes are those with mutations that are essential for tumor development and spread. Led by ICREA researcher Patrick Aloy, scientists from the Structural Bioinformatics and Network Biology (SBNB) Laboratory at IRB Barcelona have developed a computational pipeline that predicts tumor response to different cancer treatments. This system is based on the identification of […]
  • Genomic adaptations to a rice-based diet mitigate the risk of obesity and diabetes September 21, 2020
    The traditional rice-based diet of some east-Asian population has brought a number of genomic adaptations that may contribute to mitigating the spread of diabetes and obesity. An international study led by the University of Bologna and published in the journal Evolutionary Applications has recently suggested this interesting hypothesis. Researchers analyzed and compared the genomes of […]
  • Researchers identify genetic factors associated with hand-foot syndrome in chemotherapy with capecitabine September 21, 2020
    Capecitabine is a chemotherapy drug used for breast and colorectal cancer. It can extend survival rate by nearly 10%. However, recent studies revealed that almost 50% of patients develop palmar-plantar erythrodysesthesia, a skin reaction also called hand-foot syndrome with mild to serious symptoms. Up to 17% of these patients can have a burning pain in […]
  • Gene therapy corrects the cardiac effects of Friedreich's ataxia September 18, 2020
    Gene therapy was successfully used to overcome the cardiac effects of Freidreich's ataxia (FA) in a mouse model of the disease, as reported in the peer-reviewed journal Human Gene Therapy.
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    Understanding the specific mutations that contribute to different forms of cancer is critical to improving diagnosis and treatment. But limitations in DNA sequencing technology make it difficult to detect some major mutations often linked to cancer, such as the loss or duplication of parts of chromosomes.
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    Researchers have developed the world's first photodetector that can see all shades of light, in a prototype device that radically shrinks one of the most fundamental elements of modern technology.
  • New drug candidate found for hand, foot and mouth disease September 22, 2020
    Duke researchers have identified a potential drug candidate against enterovirus 71, a common cause of hand, foot and mouth disease in infants and young children. The compound of interest is a small molecule that binds to RNA, the virus's genetic material, and changes its 3-D shape in a way that stops the virus from multiplying […]
  • Web resources bring new insight into COVID-19 September 22, 2020
    Two new web resources put at researchers' fingertips information about cellular genes whose expression is affected by coronavirus infection and place these data points in the context of the complex network of host molecular signaling pathways.
  • New freshwater database tells water quality story for 12K lakes globally September 22, 2020
    Although less than one per cent of all water in the world is freshwater, it is what we drink and use for agriculture. In other words, it's vital to human survival. York University researchers have just created a publicly available water quality database for close to 12,000 freshwater lakes globally - almost half of the […]
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    More than 18 percent of US adults do not know whether they will have enough to eat from day to day, and the numbers are worse for Hispanics, Blacks, people with obesity, and women, a new report shows.
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