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Riociguat (Adempas): Kontraindikation in PH-IIP

16. September 2016 – Riociguat (Adempas) ist ein Arzneimittel, welches zur Behandlung von zwei Formen der pulmonalen Hypertonie (PH), der chronisch thromboembolischen pulmonalen Hypertonie und der pulmonalarteriellen Hypertonie (PAH), eingesetzt wird. Der Wirkstoff Riociguat ist ein Stimulator der

löslichen Guanylatzyklase (sGC),

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  • Twenty four genetic variants linked to heightened womb cancer risk February 17, 2020
    Twenty four common variations in genes coding for cell growth and death, the processing of oestrogen, and gene control factors may be linked to a heightened risk of developing womb (endometrial) cancer, indicates the most comprehensive review of the published evidence so far in the Journal of Medical Genetics.
  • Researchers discover the link between ribs and lung function in patients with brittle bone disease February 17, 2020
    A multidisciplinary team headed by Valencia University (UV) professor Juan Alberto Sanchis Gimeno reports on the link between the shape of the ribs and lung function in patients with osteogenesis imperfecta, a rare disease that affects one of every 18,000 newborns. Their study has been published in the Journal of Advanced Research.
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    Neurodevelopmental disorders, including schizophrenia and autism, likely result from complex interactions that modify the effects of individual genes. In a new study, researchers evaluated the effects of over 300 pairwise knockdowns—reducing the expression of two genes simultaneously—of the fruit fly versions of genes located in a region of human chromosome 3 that, when deleted, has […]
  • Stress in small children separated from their parents may alter genes February 14, 2020
    Experts in the emotional needs of small children say increased levels of the stress hormone cortisol in babies and small children who are separated from their parents, especially their mothers, could have a long-term genetic impact on future generations. In a commentary published by the Journal of the Royal Society of Medicine, the authors say […]
  • Autophagy genes act as tumor suppressors in ovarian cancer February 13, 2020
    Shedding light on a decades-old controversy, scientists at the Medical University of South Carolina (MUSC) and University of California at San Diego (UCSD) published findings in PLOS Genetics this month showing that autophagy or "self-eating" genes work against tumors in certain types of ovarian cancer.
  • New VA/DoD guidelines address sleep-related issues in military personnel, veterans February 17, 2020
    Military service is a risk factor for sleep disorders. Recognizing this, the US Departments of Veterans Affairs and Defense issued new guidelines for assessing and treating insomnia and obstructive sleep apnea in military personnel and veterans.
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    A multi-institutional group of researchers led by Children's Hospital of Philadelphia (CHOP) has linked a strong cancer driver gene to changes in proteins that regulate alternative splicing. The researchers created new computational tools and biological model systems for the study. This collaborative research, led by Yi Xing, PhD, at CHOP and Owen Witte, MD, at […]
  • Study identifies states with highest rates of melanoma due to ultraviolet radiation February 17, 2020
    A new study finds a wide state-by-state variation in rates of melanoma caused by ultraviolet (UV) exposure with highest rates in several states on the East and West Coast including Hawaii, but also a few landlocked states, including Utah, Vermont, and Minnesota.
  • Reconstructing the diet of fossil vertebrates February 17, 2020
    Paleodietary studies of the fossil record are impeded by a lack of reliable and unequivocal tracers. Scientists from the MPI for Evolutionary Anthropology, the MPI for Chemistry and the Johannes Gutenberg University (JGU) in Mainz have now tested a new method, the isotope analysis of zinc isotopes from the tooth enamel of fossil mammals, and […]
  • How learning about fish can help us save the Amazon rainforest February 17, 2020
    They might not be as popular as jaguars and parrots, but fish hold the key to lots of the Amazon rainforest's secrets. Studying the different kinds of fish living in the region's lakes and rivers helps scientists understand how rainforest ecosystems are connected. An investigation of fish populations is helping scientists make a case that […]
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