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Risiko einer Hepatitis-B-Reaktivierung unter Therapie mit BCR-ABL Tyrosinkinaseinhibitoren

10. April 2016 – In Deutschland informieren die Firmen Novartis, Bristol-Myers Squibb, Pfizer, und ARIAD Pharmaceuticals mittels eines Rote-Hand-Briefes über das Risiko einer Hepatitis B Virus-Reaktivierung nach Anwendung von BCR-ABL Tyrosinkinaseinhibitoren und die Notwendigkeit der Untersuchung von Patienten auf Hepatitis B Viren vor Behandlungsbeginn. Bei Patienten,

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Die Anwendung von Viekirax mit Exviera bei Child-Pugh-B und Child-Pugh-C Patienten kann zu fatalem Leberversagen führen

09. April 2016 – Gemäss einer sogenannten DHPC (Health Professional Communication) vom 8. April 2016 orientiert Swissmedic zusammen mit der Inhaberin der Zulassungsbewilligung (AbbVie) über ernsthafte und teilweise fatale Nebenwirkungen in einer Gruppe von Patientinnen / Patienten nach Hepatitis C CirrhosisBehandlung chronischer Hepatitis C  (CHC) mit Viekirax,

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Schwere Leberschädigungen, welche mit der Anwendung von Dronedaron [Multaq] in Verbindung gebracht werden.

21. Januar 2011 – In Abstimmung mit dem Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM) informiert die Firma Sanofi-Aventis über schwerwiegende Leberschädigungen, die mit der Anwendung von Dronedaron [Multaq] aufgetreten sind, sowie über notwendige Kontrolluntersuchungen.

1. Es sind Fälle von Leberschädigung bei Patienten, die mit Dronedaron [Multaq] behandelt wurden,

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  • Genetic discovery could lead to better prediction of suicide risk within families November 26, 2020
    Every 11 minutes, an American dies by suicide. That's 132 people a day or more than 48,000 annually. For those left behind, the haunting question is why.
  • The genetics of side-effects November 25, 2020
    Henk-Jan Guchelaar knows all too well the serious problems that the side-effects of medication can cause. As a professor of clinical pharmacy at the University of Leiden in the Netherlands, he has spent the last two decades trying to get the link between medicine and our genes recognised more widely.
  • Gene donors at high risk for cancer received feedback November 25, 2020
    Researchers at the Estonian Genome Center at the University of Tartu studied how people at high risk for breast, ovarian or prostate cancer responded to the feedback of genetic findings. Gene donors who chose to receive results appreciated being contacted and considered the information provided to be valuable. Authors find that knowing more about people's […]
  • Researchers reveal how genetic variations are linked to COVID-19 disease severity November 25, 2020
    Even as tens of thousands of Americans test positive for COVID-19 each day, physicians still aren't sure why some people experience mild to no symptoms while others become critically ill. New research led by Robert E. Gerszten, MD, Chief of the Division of Cardiovascular Medicine at Beth Israel Deaconess Medical Center (BIDMC) sheds new light […]
  • Study identifies new functions in the gene that causes Machado-Joseph disease November 25, 2020
    Ataxia is a minority disease with genetic origins, known for its neuromuscular alterations due to the selective loss of neurons in the cerebellum, the organ of our nervous systems which controls movement and balance. UB researchers have identified new functions in the ataxin 3 gene (ATXN3)–which causes Machado-Joseph disease, the most common type of ataxia– […]
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