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Von Neuem: Valproat-haltige Arzneimittel und Schwangerschaft

10. Februar 2018 – Der Ausschuss für Risikobewertung (PRAC) der Europäischen Arzneimittelagentur (EMA) empfiehlt neue Einschränkungen, um eine Valproat-Exposition ungeborener Kinder im Mutterleib zu vermeiden; Eine

Valproat-Exposition ungeborener Kinder kann zu angeborenen Missbildungen und Entwicklungsstörungen führen.

Der PRAC untersuchte die zur Verfügung stehenden Daten und beriet sich umfassend mit Angehörigen der Heilberufe sowie Frauen und deren Kindern,

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Valproate: Verhindert denn eine Patientenkarte teratogene Schädigungen von Kindern?

14. Juli 2017 – Das deutsche Bundesinstitut für Arzneimittel und  Medizinprodukte (BfArM) hat soeben einen von den betroffenen pharmazeutischen Unternehmen verfassten Informationsbrief zur Einführung einer Patientenkarte für Arzneimittel, welche Valproat (Valproinsäaure) und verwandte Substanzen enthalten, zu Handen der Ärzte und Apotheker veröffentlicht.

Hintergrund dieses Informationsbriefes ist der Bescheid des BfArM vom 10.

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Valproate in der Schweiz: Abgabe einer Patientenkarte

13. Oktober 2016 – Valproinsäure ist eine nicht natürlich vorkommende, verzweigte Carbonsäure. Sie und ihre Salze, kurz die “Valproate”, werden in der Medizin als Antikonvulsiva (Antiepileptika) und bei der Behandlung von bipolaren (manisch-depressiven) Störungen eingesetzt. Die Anwendung von Valproaten während der Schwangerschaft ist mit einem erheblichen Risiko kongenitaler Missbildungen und von schweren Entwicklungsstörungen des Foetus (in etwa 30 bis 40% der Fälle) begleitet.

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    A patient and family walk into a doctor's office. They hope that the latest tests will reveal what is causing the patient's illness and end the diagnostic odyssey they have been going through for years. Having an accurate diagnosis also means that maybe there is a treatment that at least can alleviate the patient's condition.
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    Many heritable immune diseases such as rheumatoid arthritis and blood-cell related traits derive from critical proteins not being made or not functioning correctly. But exactly how a person's genes, the regulation of these genes and how the resulting proteins interact to cause disease is not widely understood.
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    A common inherited genetic variant is a frequent cause of deafness in adults, meaning that many thousands of people are potentially at risk, reveals research published online in the Journal of Medical Genetics.
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    An international research collaboration, including Professor Iijima Kazumoto et al. (of the Department of Pediatrics, Kobe University Graduate School of Medicine) has revealed that NPHS1 is a disease-susceptibility gene for steroid-sensitive nephrotic syndrome in children. The NPHS1 gene encodes nephrin, a component protein for the renal glomerulus slit diaphragm, which prevents protein from being passed […]
  • Hearing and visual impairments linked to elevated dementia risk July 8, 2020
    Older adults with both hearing and visual impairments--or dual sensory impairment--had a significantly higher risk for dementia in a recent study published in Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring.
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    Workers in jobs that typically involve heavy lifting, frequent climbing, prolonged kneeling, squatting, and standing face an increased risk of developing knee osteoarthritis. That's the conclusion of a new analysis published in Arthritis Care & Research.
  • Bacteria in infants' first stool may indicate their risk of obesity July 8, 2020
    Meconium--the earliest stool of an infant -- is composed of materials ingested during the time the infant spends in the uterus. A new study published in Pediatric Obesity found that the types of normal bacteria found in the meconium may predict an infant's likelihood of later developing obesity.
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    In a clinical trial of patients with rheumatoid arthritis, treatment with a drug called upadacitinib provided greater benefits than methotrexate, the most commonly used initial therapy for rheumatoid arthritis.
  • Early clinical trial tests treatment strategy for pancreatic cancer July 8, 2020
    Pancreatic cancer carries a poor prognosis, and it often goes undetected until advanced stages. A new BJS (British Journal of Surgery) study indicates that a certain cocktail of chemotherapy drugs may be a safe and effective treatment option for patients with a metastatic form of the disease.
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