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Tamoxifen [Novaldex]: Ungünstige Wechselwirkung mit SSRIs (Serotonin-Wiederaufnahmehemmern)

Posted on by by Posted in Behördliche Mitteilung, Gravierende Unerwünschte Nebenwirkung, Pharmakogenetik, Thasso Post, Theragenomische Medizin No Comments ↓

13. Mai 2010 – Wie das Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM)  mitteilt, wurde in einer kanadischen Kohortenstudie gezeigt, dass der Serotonin-Wiederaufnahmehemmer (SSRI) Paroxetin die Wirkung von Tamoxifen in der Hormonbehandlung eines Mammakarzinoms herabsetzen kann (BMJ 2010; 340:c693). Bei gleichzeitiger Verabreichung von Tamoxifen und Paroxetin ergab sich eine Erhöhung der Brustkrebssterblichkeit.

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Tamoxifen: Wechselwirkung mit SSRIs (Serotonin-Wiederaufnahmehemmern)

Posted on by by Posted in Arzneimittelinteraktionen, Behördliche Mitteilung, Pharmakogenetik, Thasso Post, Theragenomische Medizin, Unerwünschte Arzneimittel Nebenwirkungen No Comments ↓

21.  März 2010 – In einer kanadischen Kohortenstudie wurde gezeigt, dass der Serotonin-Wiederaufnahmehemmer (SSRI) Paroxetin die Wirkung von Tamoxifen in der Hormonbehandlung eines Mammakarzinoms herabsetzen kann.  Bei gleichzeitiger Verabreichung von Tamoxifen und Paroxetin ergab sich eine Erhöhung der Brustkrebssterblichkeit.

Sowohl Tamoxifen als auch SSRIs wie Paroxetin werden über das P450-System der Leber metabolisiert.

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Clopidogrel-haltige Arzneimittel (Plavix®, Iscover®): potentielle Wechselwirkungen mit Protonen-Pumpen-Inhibitoren (PPIs)

Posted on by by Posted in Arzneimittelinteraktionen, Behördliche Mitteilung, Personalisierte Medizin, Pharmakogenetik, Thasso Post, Theragenomische Medizin No Comments ↓

6. August 2009 – In einer Mitteilung vom 4. August 2009 bittet das Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM) um dringende Beachtung der aktualisierten Warnhinweise und Vorsichtsmaßnahmen in der Fachinformation zu Clopidogrel [Plavix] und Clopidogrel [Iscover]. Zu den Änderungen werden Rote-Hand-Briefe versendet. Hier folgend finden sie den leicht editierten und gekürzten Inhalt des Rote Hand Briefes für Plavix®.

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RSS random genetics

  • Distinct social profile and high ASD risk, 3q29 deletion survey finds July 19, 2019
    A survey of 93 people with 3q29 deletion syndrome reveals a distinct pattern of social disability and anxiety, even without a diagnosis of autism spectrum disorder. The results were published online in Molecular Autism on July 16.
  • Study sheds light on the darker parts of our genetic heritage July 19, 2019
    More than half of our genome consists of transposons,DNA sequences that are reminiscent of ancient, extinct viruses.Transposons are normally silenced by a process known as DNA methylation, but their activation can lead to serious diseases. Very little is known about transposons but researchers in an international collaboration project have now succeeded for the first time […]
  • Molecular cause for severe multi-organ syndrome July 19, 2019
    Three unrelated families on three continents (from continental Portugal, the United States and Brazil), all with healthy ancestors, had children with a very rare multi-organ condition that causes early-onset retinal degeneration, sensorineural hearing loss, microcephaly, intellectual disability, and skeletal dysplasia with scoliosis and short stature.
  • Researchers determine epigenetic origin of docetaxel-resistant breast cancer July 19, 2019
    Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) have published a study in Molecular Cancer Research in which they identify methylation patterns associated with different subtypes of breast cancer, and a subclassification of the group of "triple negatives," a breast cancer type typically associated with poor prognosis. In addition, they identified changes in DNA methylation […]
  • Researchers report the function of reverse-twisting DNA July 19, 2019
    Normally, the two strands of the DNA double helix wind around each other in a right-handed spiral. However, there is another conformation called Z-DNA in which the strands twist to the left. The function of Z-DNA has remained a mystery since its discovery. A newly published paper unambiguously establishes that the Z-conformation is key to […]

RSS random science

  • Study sheds light on the darker parts of our genetic heritage July 19, 2019
    More than half of our genome consists of transposons, DNA sequences that are reminiscent of ancient, extinct viruses. Transposons are normally silenced by a process known as DNA methylation, but their activation can lead to serious diseases. Very little is known about transposons but researchers in an international collaboration project have now succeeded for the first time […]
  • Flexible user interface distribution for ubiquitous multi-device interaction July 19, 2019
    KAIST researchers have developed mobile software platform technology that allows a mobile application (app) to be executed simultaneously and more dynamically on multiple smart devices. Its high flexibility and broad applicability can help accelerate a shift from the current single-device paradigm to a multiple one, which enables users to utilize mobile apps in ways previously […]
  • Atomically precise models improve understanding of fuel cells July 19, 2019
    Simulations from researchers in Japan provide new insights into the reactions occurring in solid-oxide fuel cells by using realistic atomic-scale models of the electrode active site based on microscope observations instead of the simplified and idealized atomic structures employed in previous studies. This better understanding of how the structures in the cells affect the reactions […]
  • Predicting long-term risk of death from chest X-rays July 19, 2019
    Researchers in this study looked at whether a computing system that analyzed data from thousands of chest X-rays of smokers and nonsmokers and developed a risk score could predict long-term risk of death.
  • Ivacaftor may reduce common infections in patients with CF July 19, 2019
    Patients with cystic fibrosis who take ivacaftor appear to have fewer respiratory infections over time than those not taking the drug, according to new research published online in the Annals of the American Thoracic Society.
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