the glocalized network in theragenomic and personalized medicine and the genetics of individual patients safety of drugs
February 20, 2020 – Traditional cardiovascular risk factors often assessed in an annual physical, such as blood pressure, cholesterol levels, diabetes, and smoking status, may at least be as valuable in predicting who will develop coronary heart disease (CHD) as …
November 03, 2019 – Cystic fibrosis (CF) is a lethal, inherited genetic disease affecting more than 70,000 people worldwide. It is usually diagnosed in childhood and causes abnormal buildup of thick mucus in the lungs and digestive tract that leads …
In Caribbeans cystic fibrosis (CF) is driven by very rare CFTR mutations Read more »
September 18, 2019 – This post is an edited version of parts of a paper that appeared in the Journal of Personalised Medicine (JPM) a week ago und which addresses one of the important topics in connection with the themes of …
Clinical evidence and implementation challenges for pharmacogenomic testing Read more »
August 28, 2019 – Immune checkpoint inhibitor (ICI) therapy is a form of cancer immunotherapy. The therapy targets immune checkpoints, key regulators of the immune system that when stimulated can dampen the immune response to an immunologic stimulus. Some cancers …
Variables of prospective response rates of PD-1/PD-L1 based therapies across cancers Read more »
August 03, 2019 – Africa is considered the original cradle of all humanity, to which all humans can trace their genetic origin. This may be very interesting in the context of diseases that are due to genetic predispositions both in …
ZRANB3 in African Populations: New Type 2 Diabetes risk locus identified Read more »
July 26, 2019 – “Blockchains for secure digitized medicine”. This is the title of a very interesting and important article in the Journal of Personalised Medine (JPM) as of May 28, 2019. Blockchain as an emerging technology (particularly around the hype …
The phenotype broker: Blockchain and patient phenotype Read more »
June 20, 2019 – Male infertility is a serious treat in very many relations. While a priori, male infertility does not affect the physical health of the afflicted, it may very much affect the psychological health of the individual, and that …
May 29, 2019 – Spinal muscular atrophy (SMA) is a group of neuromuscular disorders that result in the loss of motor neurons and progressive muscle wasting. The severity of symptoms and age of onset varies by the type. Some types are apparent at …
Gene therapy: Zolgensma to treat spinal muscular atrophy Read more »
December 20, 2018 – This is very troubling news for all patients worldwide with diabetes and who are under therapy with drugs out of the DPP-4 class of inhibitors: A very recent population-based epidemiological study indicates that patients under DPP-4 inhibitors …
Cholangiocarcinoma: Diabetes Drugs In DPP-4 Inhibitor Class Associated With Doubled Risk Read more »
December 12, 2018 – The application of CRISPR/Cas9 based molecular technology in the field of gene editing (or genome editing) has recently had its exploded limelight exposure for a couple of reasons. The question arises if this exposure is earned or …
CRISPR/Cas9 for the Treatment of Duchenne Muscular Dystrophy: Prime time already? Read more »