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Heart disease prediction by traditional risk factors as good as with an exhaustive genetic test

February 20, 2020 – Traditional cardiovascular risk factors often assessed in an annual physical, such as blood pressure, cholesterol levels, diabetes, and smoking status, may at least be as valuable in predicting who will develop coronary heart disease (CHD) as a sophisticated genetic test that surveys millions of different points in DNA,

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Cholangiocarcinoma: Diabetes Drugs In DPP-4 Inhibitor Class Associated With Doubled Risk

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Heart attacks and stroke: The risk of DPP-4 anti-diabetes drugs

May 06, 2018 – In April 2016 the American Food and Drug Administration (FDA) took regulatory action by mandating label changes with new warnings about an increased risk of heart failure for  new diabetes medicines in the dipeptidyl peptidase-4 (DPP-4) inhibitor drug class, including Saxagliptin (Onglyza),

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Diabetes is manageable if you know how

November 14, 2017 – Diabetes is manageable if you know how

Article by author Chloe Pearson.

Article top photo Jenny Hill at Unplash.

If you have diabetes, you already know that staying healthy is going to be a challenge: Keeping track of your blood sugar,

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Diabetes: Is rhabdomyolysis associated with DPP-IV inhibitors?

October 15, 2017 – According to the quarterly safety report April – June 2017 by the American Food & Drug Administration (FDA), originating from the  FDA Adverse Event Reporting System (FAERS), the class of diabetes drugs referred to as dipeptidyl peptidase-4 inhibitors (DPP-IV inhibitors) may be associated with rhabdomyolysis,

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Is there a heightened risk of heart failure with diabetes medications containing saxagliptin and alogliptin?

April o5, 2016 – There have been indications that a heightened risk of heart failure may be associated with diabetes medications containing the pharmacologically active ingredients saxagliptin or alogliptin.  In the US, this includes  the FDA-approved drugs Saxagliptin (Onglyza), Saxagliptin/Metformin (Kombiglyze XR), Alogliptin (Nesina), Alogliptin/Metformin (Kazano), and Alogliptin/Pioglitazone (Oseni).

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Diabetes-Arzneimittel mit dem Wirkstoff Rosiglitazon – Vorgesehene Sistierung der Zulassung in der Europäischen Union.

23. September 2010 – Das Arzneimittel-Institut der Schweiz (Swissmedic) hat heute folgende Mitteilung veröffentlicht:

23.9.10. – Swissmedic.  Die Arzneimittelbehörde der EU (EMEA) sieht vor, die Zulassung der Diabetes-Medikamente mit dem Wirkstoff Rosiglitazon zu suspendieren; sie werden dort in einigen Monaten nicht mehr erhältlich sein. Mit diesem Wirkstoff sind in der Schweiz die Präparate Avandia® und Avandamet® Tabletten zugelassen (Rosiglitazon bzw.

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European Medicines Agency (EMEA) recommends withdrawal of Benfluorex from the market in European Union

December 31, 2009 – The European Medicines Agency (EMEA) has recommended the withdrawal of all medicines containing Benfluorex in the European Union, because their risks, particularly the risk of heart valve disease, are greater than their benefits.

Doctors should stop prescribing Benfluorex-containing medicines and consider alternative treatments.

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  • Spinal muscular atrophy (SMA): Newborn screening promises a benefit April 6, 2020
    On behalf of the Federal Joint Committee (G-BA), the Institute for Quality and Efficiency in Health Care (IQWiG) investigated whether it is meaningful to test newborns in Germany for spinal muscular atrophy (SMA) in combination with earlier diagnosis and treatment. The Institute's final report is now available.
  • Alport syndrome severity can be predicted by causative protein genotype April 6, 2020
    A Japanese research team has successfully developed a system to predict the severity of Alport syndrome, a serious hereditary kidney disease that occurs in about 1 out of 5,000 people in the US. Patients with Alport syndrome have abnormalities in the causative protein, type IV collagen, that often lead to chronic renal dysfunction requiring dialysis. […]
  • Research: Hereditary mutation drives aggressive head and neck, lung cancers in Asian population April 6, 2020
    Researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) have uncovered a genetic variant in a gene called MET that is responsible for more aggressive growth of head and neck, and lung cancers. A further probe into the finding revealed therapeutic strategies that could potentially target this […]
  • New insights into the genetic risk factors and disease pathways of multiple sclerosis April 6, 2020
    Multiple sclerosis (MS) is a debilitating disease in which the body's own immune system attacks itself and can, over time, permanently destroy the protective sheaths, or myelin, around nerve fibers in the brain. Myelin insulates nerve cells and facilitates the transmission of messages along them. When the myelin sheath is damaged, the nerves themselves may […]
  • Findings in mice reveal possibilities for fetal drug therapy for deafness April 6, 2020
    New research led by hearing scientists at Oregon Health & Science University suggests an avenue to treat and prevent intractable genetic disorders before birth.
  • Magnetoacoustic waves: Towards a new paradigm of on-chip communication April 6, 2020
    Researchers have observed directly and for the first time magnetoacoustic waves (sound-driven spin waves), which are considered as potential information carriers for novel computation schemes. These waves have been generated and observed on hybrid magnetic/piezoelectric devices. The experiments were designed by a collaboration between the University of Barcelona (UB), the Institute of Materials Science of […]
  • An updated overview of the complex clinical spectrum of tourette syndrome April 6, 2020
    Background: Tourette syndrome is a common nerve development disorder which is characterized by a variety of muscle or vocal movements called 'tics', often involuntary. The disorder is reflectively and quite erroneously associated by many as a just syndrome with tics and the frequent use of undesirable language (swearing). However, Tourette syndrome is a complex neuropsychiatric […]
  • Oil spill: where and when will it reach the beach? Answers to prevent environmental impacts April 6, 2020
    When an accident involving oil spills occurs, forecasting the behaviour of the oil slick and understanding in advance where and when it will reach the coastline is crucial to organize an efficient emergency response that is able to limit environmental and economic repercussions. A study led by CMCC Foundation's researchers, based on the concrete case […]
  • Which healthy lifestyle factors associated with more years free of chronic disease? April 6, 2020
    What combination of healthy lifestyle factors were associated with the most years lived without chronic diseases was the focus of this analysis that included data from more than 100,000 adults who were participants in 12 European studies.
  • Leaving its mark: How frailty impacts the blood April 6, 2020
    Fifteen blood metabolites are key for diagnosing the age-related disorder, frailty, new study finds.
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