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Cholangiocarcinoma: Diabetes Drugs In DPP-4 Inhibitor Class Associated With Doubled Risk

Posted on by by Posted in Adverse Drug Reaction [ADR], Genetic Background, Genetic Predisposition, Genetic Susceptibility, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

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The weight-management drug Liraglutide (Saxenda) has just been approved by the FDA

Posted on by by Posted in New Drug Approval, Thasso Post 1 Comment ↓

December 23, 2014 – The U.S. Food and Drug Administration (FDA) just approved Saxenda (liraglutide [rDNA origin] injection) as a treatment option for chronic weight management in addition to a reduced-calorie diet and physical activity.

The drug is approved for use in adults with a body mass index (BMI) of 30 or greater (obesity) or adults with a BMI of 27 or greater (overweight) who have at least one weight-related condition such as hypertension,

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RSS random genetics

  • How genetic variation gives rise to differences in mathematical ability October 22, 2020
    DNA variation in a gene called ROBO1 is associated with early anatomical differences in a brain region that plays a key role in quantity representation, potentially explaining how genetic variability might shape mathematical performance in children, according to a study published October 22nd in the open-access journal PLOS Biology by Michael Skeide of the Max […]
  • High-quality cat genome helps identify novel cause of dwarfism October 22, 2020
    A new and improved cat genome developed by the feline research teams at the University of Missouri and Texas A&M University has already proven to be a valuable tool for feline biomedical research by helping to confirm existing gene variants and new candidate genes underlying diseases in cats. The new findings are published October 22nd […]
  • Multiple sclerosis as the flip side of immune fitness October 22, 2020
    About half of the people with multiple sclerosis have the HLA-DR15 gene variant. A study led by the University of Zurich has now shown how this genetic predisposition contributes to the development of the autoimmune disease multiple sclerosis in combination with environmental factors. The decisive factor is the shaping of a repertoire of immune cells […]
  • Scientists use gene therapy and a novel light-sensing protein to restore vision in mice October 22, 2020
    A newly developed light-sensing protein called the MCO1 opsin restores vision in blind mice when attached to retina bipolar cells using gene therapy. The National Eye Institute, part of the National Institutes of Health, provided a Small Business Innovation Research grant to Nanoscope, LLC for development of MCO1. The company is planning a U.S. clinical […]
  • Diagnostic, therapeutic advance for rare neurodegenerative disorder October 21, 2020
    Mayo Clinic researchers, along with national and global collaborators, have developed a potential test for Machado-Joseph disease, or spinocerebellar ataxia type 3 (SCA3)—a disease that has no cure. They also have clarified the role of a gene target associated with the disease.

RSS random science

  • Cicada-inspired waterproof surfaces closer to reality, researchers report October 22, 2020
    A multidisciplinary group that studies the physical and chemical properties of insect wings has demonstrated the ability to reproduce the nanostructures that help cicada wings repel water and prevent bacteria from establishing on the surface. The new technique - which uses commercial nail polish - is economical and straightforward, and the researchers said it will […]
  • Lab-grown mini-lungs mimic the real thing - right down to covid infection October 22, 2020
    A team of Duke researchers has developed a lab-grown living lung model that mimics the tiny air sacs of the lungs where coronavirus infection and serious lung damage take place. This advance has enabled Duke and UNC virologists to watch the battle between the SARS-CoV-2 coronavirus and lung cells at the finest molecular scale. In […]
  • Comparing canine brains using 3D-endocast modelling October 22, 2020
    Based on digital endocranial cast models the canine brain does not increase proportionally with body size. Researchers at ELTE Eötvös Loránd and Kaposvár University in Hungary reconstructed the surface morphology of 28 canine brains, including various dog breeds, wolves, coyotes, and jackals. The shortening of the facial skeleton greatly influences the ratio of certain brain […]
  • Study: Malaria-preventive drugs dramatically reduce infections in school children October 22, 2020
    Use of preventive antimalarial treatments reduces by half the number of malaria infections among schoolchildren, according to a new analysis published today in The Lancet Global Health.
  • The Lancet Infectious Diseases: Study provides estimates of the effect of introducing and lifting physical distancing measures on COVID-19 reproduction (R) number October 22, 2020
    Analysis suggests that individual measures (including school closure, workplace closure, public events ban, ban on gatherings of more than ten people, requirements to stay at home, and internal movement limits) are associated with a reduction in transmission of SARS-CoV-2 but combined measures are more effective at reducing transmission, according to a modelling study published in […]
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