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Patisiran (Onpattro): First targeted RNA-based therapy approved to treat hATTR

Posted on August 13, 2018 by by

thassodotcom Posted in Genetic Background, New Drug Approval, Rare Diseases, Targeted Therapy, Thasso Post, Theragenomic Medicine No Comments ↓

August 14, 2018 – The American Food and Drug Administration (FDA) just approved Patisiran (Onpattro) infusion for the treatment of peripheral nerve disease (polyneuropathy) caused by hereditary transthyretin-mediated amyloidosis (hATTR) in adult patients.

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Cancer is not like cancer: Ethnic background matters

Posted on November 24, 2017 by by

thassodotcom Posted in Ethnicity, Genetic Background, New Research, Personalized Medicine, Targeted Therapy, Thasso Post, Theragenomic Medicine No Comments ↓

November 24, 2017 – New research indicates that one-size treatment for one form of blood cancer likely does not fit all, particularly when it comes to ethnic differences of patients. Thus, African-American men are three times more likely to be diagnosed with multiple myeloma,

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Besponsa: Is this really a viable new treatment for ALL?

Posted on August 18, 2017 by by

thassodotcom Posted in New Drug Approval, Targeted Therapy, Thasso Post, Theragenomic Medicine No Comments ↓

August 18, 2017 – B-cell precursor acute lymphoblastic leukemia (ALL) is a aggressive and rapidly progressing type of cancer in which the bone marrow makes too many B-cell lymphocytes, an immature type of white blood cell. In the United States, the National Cancer Institute estimates that approximately 5,970 people will be diagnosed with B-cell ALL this year and approximately 1,440 will die from the disease.

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Eteplirsen (Exondys 51) for Duchenne Muscular Dystrophy (DMD) approved

Posted on September 20, 2016 by by

thassodotcom Posted in Genetic Background, In The Press, New Drug Approval, Personalized Medicine, Pharmacogenetics, Rare Diseases, Regulatory Approval, Targeted Therapy, Thasso Post, Theragenomic Medicine No Comments ↓

September 19, 2016 – This post presents below a virtually unedited announcement by the American Food & Drug Administration (FDA) concerning Duchenne Muscular Dystrophy (DMD) therapy option which gives much hope for at least some of the affected patients.

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The HCV saga goes on: Epclusa has been approved for treatment of chronic Hepatitis C virus (HCV) infection

Posted on June 29, 2016 by by

thassodotcom Posted in New Drug Approval, Thasso Post, Theragenomic Medicine 2 Comments ↓

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Hope for patients with urothelial carcinoma: Atezolizumab (Tecentriq) approved

Posted on May 20, 2016 by by

thassodotcom Posted in New Drug Approval, Targeted Therapy, Thasso Post, Theragenomic Medicine No Comments ↓

May 18, 2016 – Over the last two years, biologics targeting the PD-1/PD-L1 pathway (proteins found on the body’s immune cells and some cancer cells), notably Nivolumab (Opdivo) and Pembrolizumab (Keytruda), have come to the clinic for the treatment of a selection of oncologic indications.

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Venetoclax (Venclexta) for the treatment of patients with chronic lymphocytic leukemia (CLL)

Posted on April 12, 2016 by by

thassodotcom Posted in New Drug Approval, Targeted Therapy, Thasso Post, Theragenomic Medicine No Comments ↓

April 12, 2016 – The American Food and Drug Administration (FDA) just approved Venetoclax (Venclexta) for the treatment of patients with chronic lymphocytic leukemia (CLL) who have a chromosomal abnormality called 17p deletion and who have been treated with a least one prior therapy.

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Theragenomic Medicine: Gefinitib (Iressa) targeted therapy for first-line treatment of patients with a type of metastatic lung cancer approved

Posted on July 14, 2015 by by

thassodotcom Posted in Allelische Variante, New Drug Approval, Targeted Therapy, Thasso Post, Theragenomic Medicine 3 Comments ↓

July 13, 2015 – This post persents a press announcement by the U.S. Food and Drug Administration (FDA). The text has slightly been edited by the autor of this blog. Thus, FDA today approved Gefinitib (Iressa) for the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors harbor specific types of epidermal growth factor receptor (EGFR) gene mutations,

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Theragenomic Medicine: Targeted Therapies and Associated Toxicity

Posted on March 22, 2015 by by

thassodotcom Posted in Adverse Drug Reaction [ADR], Targeted Therapy, Thasso Post, Theragenomic Medicine 2 Comments ↓

March 22, 2015 – This post addresses a topic which often gets lost in the current hype on targeted and precision (theragenomic) medicine. The issue is that targeted therapies are not only very precise and highly effective (in most patients) but they often also come with considerable clinical toxicity.

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Tags: Targeted Cancer Therapy, Targeted Therapy, Targeted Toxicity, Theragenomic Medicine

Theragenomic Medicine: Palbociclib (Ibrance) approved for postmenopausal women with advanced (metastatic) breast cancer

Posted on February 8, 2015 by by

thassodotcom Posted in New Drug Approval, Personalized Medicine, Targeted Therapy, Thasso Post, Theragenomic Medicine, Theragenomics No Comments ↓

February 8, 2015 – The American Food and Drug Administration (FDA) has granted accelerated approval to Palbociclib (Ibrance) to treat advanced (metastatic) breast cancer. The FDA granted Ibrance breakthrough therapy designation because the sponsor demonstrated through preliminary clinical evidence that the drug may offer a substantial improvement over available therapies.

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