Genetic Predisposition

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Abdominal aortic aneurysm: Genetic scoring can identify more men at risk

Posted on May 7, 2020 by by

Joseph Gut - thasso Posted in Genetic Predisposition, Genetic Susceptibility, New Research, On The Horizon, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

May 07, 2020 – Abdominal aortic aneurysm (AAA) is a localized enlargement of the abdominal aorta such that the diameter is greater than 3 cm or more than 50% larger than normal. AAAs usually cause no symptoms, except during rupture.

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Could DNA testing help the most seriously affected Covid-19 patients?

Posted on April 28, 2020 by by

Joseph Gut - thasso Posted in Allelic Variant, Genetic Background, Genetic Predisposition, New Research, Personomics, Thasso Post, Theragenomic Medicine No Comments ↓

April 28, 2020 – Coronavirus disease 2019 (Covid-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease was first identified in December 2019 in Wuhan, the capital of China’s Hubei province,

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Klotho’s role in some patients with Alzheimer’s disease revealed?

Posted on April 24, 2020 by by

Joseph Gut - thasso Posted in Allelic Variant, Genetic Background, Genetic Predisposition, New Research, Personomics, Thasso Post, Theragenomic Medicine 1 Comment ↓

April 24, 2020 – The klotho gene is named after the fanciful Greek goddess of destiny Clotho who turns the string of life known to be related with longer life and improved cognizance. In modern biology, allelic variants of the klotho gene in fact have been associated with long life span.

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Inherited mutation in ELP1 predisposes children to medulloblastoma

Posted on April 3, 2020 by by

Joseph Gut - thasso Posted in Genetic Predisposition, New Research, Thasso Post, Theragenomic Medicine, Uncategorized No Comments ↓

April 03, 2020 – Medulloblastoma is the most common malignant pediatric brain tumor. Medulloblastomas are invasive, rapidly growing tumors that, unlike most brain tumors, spread through the cerebrospinal fluid and frequently metastasize to different locations along the surface of the brain and spinal cord.

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Large genetic map of psychiatric disorders completed

Posted on March 15, 2020 by by

Joseph Gut - thasso Posted in Allelic Variant, Genetic Background, Genetic Predisposition, Thasso Post, Theragenomic Medicine 3 Comments ↓

March 15, 2020 – An international study published in the journal Cell has described 109 genetic variants associated with eight psychiatric disorders such as autism, ADHD, schizophrenia, bipolar disorder, depression, obsessive-compulsive disorder and Tourette syndrome in a total of about 230,000 patients worldwide.

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Are Asians at higher genetic risk of serious adverse events to common medications?

Posted on March 10, 2020 by by

Joseph Gut - thasso Posted in Adverse Drug Reaction [ADR], Allelic Variant, Ethnicity, Genetic Predisposition, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

March 10, 2020 – A widespread assumption is, the people of Asian descent are more prone to serious, sometimes deadly adverse drug reactions, even when taking rather common medications prescribed for gout through to depression. In the ages of genetics and precision medicine, the question then comes up if Asian people could be at such heightened risk because of underlying particular genetic factors.…

HSD3B1 Genotype Predicts Prostate Cancer Outcomes

Posted on February 28, 2020 by by

Joseph Gut - thasso Posted in Allelic Variant, Genetic Background, Genetic Predisposition, New Research, Thasso Post, Theragenomic Medicine No Comments ↓

February 28, 2020 – A very recent report elucidates the possible prospective power of the knowledge about the genetic background of patients when concerned with certain clinical endpoints (disease states) and associated genes.

The researchers in the present study analyzed outcomes in white men enrolled in the E3805 CHAARTED clinical trial according to HSD3B1 genotype,

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Genetic variants of the NUDT15 gene drive toxicity in leukemia therapy

Posted on February 27, 2020 by by

Joseph Gut - thasso Posted in Allelic Variant, Genetic Background, Genetic Predisposition, New Research, Thasso Post, Theragenomic Medicine No Comments ↓

February 27, 2020 – Thiopurines are important antimetabolite drugs, which make up a critical part of curative treatment for ALL. Genetic variations can directly influence drug toxicity and effectiveness of thiopurines. Researchers at St. Jude and elsewhere previously identified NUDT15 variants as a major genetic cause of toxicity during thiopurine therapy,

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Heart disease prediction by traditional risk factors as good as with an exhaustive genetic test

Posted on February 20, 2020 by by

Joseph Gut - thasso Posted in Genetic Background, Genetic Predisposition, Genetic Susceptibility, Personalized Medicine, Personomics, Thasso Post, Theragenomic Medicine No Comments ↓

February 20, 2020 – Traditional cardiovascular risk factors often assessed in an annual physical, such as blood pressure, cholesterol levels, diabetes, and smoking status, may at least be as valuable in predicting who will develop coronary heart disease (CHD) as a sophisticated genetic test that surveys millions of different points in DNA,

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Soccer Headers Might Be More Risky for APOE4 Genotype Carriers

Posted on February 1, 2020 by by

Joseph Gut - thasso Posted in Allelic Variant, Genetic Background, Genetic Predisposition, Genetic Susceptibility, In The Press, New Research, Thasso Post, Theragenomic Medicine No Comments ↓

February 01, 2020 – Soccer headers might be more risky for APOE4 genotype carriers – this is the headline of a very recent Reuters Health article appearing in Medscape. Thus, soccer players with apolipoprotein E4 (APOE4) genotype may want to limit how many headers they do,

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David Walliams on Is genetic testing of value for ALS patients?: “CURED FROM GENITAL HERPES More than 5 years ago I was in pain with this deadly herpes virus, A few…” Nov 7, 16:08
Raul Malkovic on Is genetic testing of value for ALS patients?: “HOW MY WIFE GOT CURED FROM ALS Below is how i got a cure for my wife who suffered from Amyotrophic Lateral Sclerosis…” Nov 6, 21:18
Pamela Erickson on Is genetic testing of value for ALS patients?: “My husband was diagnosed with ALS (amyotrophic lateral sclerosis) when he was 63 years old 4 years ago. The Rilutek…” Aug 13, 13:04
thassodotcom on Unlucky women with BIA-ALCL: An update: “The Therapeutic Goods Agency (TGA) of Australia has just issued a hazard alert concerning the risk of breast implant-associated anaplastic…” Aug 4, 09:17
thassodotcom on Tofacitinib (Xeljanz): Dangers of blood clots in the lungs and of death: “According to its Drug Safety Communication from 07/26/2019, the FDA has approved new warnings about an increased risk of blood…” Aug 4, 08:40

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Blog Archives

Abdominal aortic aneurysm: Genetic scoring can identify more men at risk

Could DNA testing help the most seriously affected Covid-19 patients?

Klotho’s role in some patients with Alzheimer’s disease revealed?

Inherited mutation in ELP1 predisposes children to medulloblastoma

Large genetic map of psychiatric disorders completed

Are Asians at higher genetic risk of serious adverse events to common medications?

HSD3B1 Genotype Predicts Prostate Cancer Outcomes

Genetic variants of the NUDT15 gene drive toxicity in leukemia therapy

Heart disease prediction by traditional risk factors as good as with an exhaustive genetic test

Soccer Headers Might Be More Risky for APOE4 Genotype Carriers

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Host factors may influence Covid-19 severity more than viral genetic variation

Abdominal aortic aneurysm: Genetic scoring can identify more men at risk

Besides the now approved remdesivir: Emerging options to treat Covid-19

Could DNA testing help the most seriously affected Covid-19 patients?

Klotho’s role in some patients with Alzheimer’s disease revealed?

First therapy for children with debilitating NF-1 approved in the USA

Inherited mutation in ELP1 predisposes children to medulloblastoma

Are Asians at higher genetic risk of serious adverse events to common medications?

Covid-19: Be careful with chloroquine and hydroxychloroquine

The phenotype broker: Blockchain and patient phenotype

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