Genetic Predisposition

Blog Archives

In Caribbeans cystic fibrosis (CF) is driven by very rare CFTR mutations

Posted on November 3, 2019 by by

thassodotcom Posted in Allelic Variant, Ethnicity, Genetic Predisposition, Genetic Susceptibility, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

November 03, 2019 – Cystic fibrosis (CF) is a lethal, inherited genetic disease affecting more than 70,000 people worldwide. It is usually diagnosed in childhood and causes abnormal buildup of thick mucus in the lungs and digestive tract that leads to trouble breathing,

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Tags: Caribbean Descent, Caucasian Descent, CFTR Allelic Variant, CFTR Gene, CFTR Gene Mutations, Cystic Fibrosis (CF), Ethnic Health Inequality, p.Phe508del, Thasso Post, Theragenomic Medizine

Is laziness a personal choice or a genetic trait?

Posted on November 2, 2019 by by

thassodotcom Posted in Genetic Background, Genetic Predisposition, New Research, Thasso Post, Theragenomic Medicine No Comments ↓

November 02, 2019 – Is laziness a choice or genetic trait? At the age where genetics seems to explain everything, it is certainly interessant to learn that a seemingly personal choice such as laziness as such may loom somewhere in your genetic outfit. Perhaps, you can not escape your laziness behaviour,

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Tags: Genetic Predisposition, Laziness, Personal Choice, PKIA Gene, Thasso Post, Theragenomics Medicine

After an over the counter genetic test: Would you make serious health decisions?

Posted on October 27, 2019 by by

thassodotcom Posted in Allelic Variant, Genetic Background, Genetic Predisposition, Genetic Susceptibility, Thasso Post, Theragenomic Medicine No Comments ↓

October 27, 2019 – Genetic tests sold online and in shops are en vogue. More and more patients strive for it, and they (the patients) are getting back results. Results, the normal patient has no chance to understand. Not even most of treating physicians are capable to interpret in favour of their patients.

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Tags: Clinical Phenotype, Compound Heterozytoges, Confounding Factors, Direct To Consumer Genetic Testing (DTCGT), Direct To Consumer Theragenomic Testing (DTCTT), False Negative Results, False Positive Results, Genotype, Molecular Phenotype, Pharmacogenomics, Thasso Post, Theragenomic Medicine, Theragenomics, Transcriptional Bursting

Hidden secrets in African genomes revealed by large scale sequencing

Posted on October 20, 2019 by by

thassodotcom Posted in Ethnicity, Genetic Background, Genetic Predisposition, Genetic Susceptibility, Thasso Post, Theragenomic Medicine No Comments ↓

October 20, 2019 – Sequencing African genomes yields new data resource with broad applicability. By collaborating globally in a new, large-scale effort, researchers have made strong progress in sequencing genomes from regions and countries across Africa. These findings will enable more broadly representative and relevant studies ranging from basic through clinical genetics.

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Tags: African Population, Ethnicity, Ethnolinguistic Group, Genetic Diversity, Genetic Predisposition, Genetic Susceptibility, H3Africa, Human Heredity and Health in Africa Consortium (H3Africa), Natural Selection, Survival Of The Fittest, Thasso Post, Theragenomic Medicine, Viral Infection

Clinical evidence and implementation challenges for pharmacogenomic testing

Posted on September 18, 2019 by by

thassodotcom Posted in Allelic Variant, Genetic Background, Genetic Predisposition, Genetic Susceptibility, Personalized Medicine, Personomics, Pharmacogenetics, Thasso Post, Theragenomic Medicine No Comments ↓

September 18, 2019 – This post is an edited version of parts of a paper that appeared in the Journal of Personalised Medicine (JPM) a week ago und which addresses one of the important topics in connection with the themes of personalised medicine,

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Tags: All of Us Project, Canadian Association of Genetic Counsellors, Clinical Pharmacogenetics Implementation Consortium (CPIC), Direct To Consumer Genetic Testing (DTCGT), Dutch Pharmacogenetics Working Group (DPWG), Genetic Testing, Next Generation Sequencing (NGS), Pharmacogenomics, PharmGKB, PREDICT Program, Right Dose, Right Drug, Right Time Protocol (RIGHT Protocol), Thasso Post, Theragenomic Medicine, Ubiquitous Pharmacogenomics Project (UPGX), US National Society of Genetic Counselors

Staying wakeful for the day: A second short sleep gene identified

Posted on September 6, 2019 by by

thassodotcom Posted in Allelic Variant, Genetic Predisposition, New Research, Personomics, Thasso Post, Theragenomic Medicine No Comments ↓

September 06, 2019 – Wakefulness varies largely among human individuals. Barring individuals suffering from diseases such as narcolepsy that may heavily dictate an individual’s daily sleep and wakefulness pattern, there are individuals in the general population who needs a lot of sleep and there are those who seemingly never sleep and still feel fit and good at performing their daily tasks.

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Tags: ADRB1 Gene, DEC2 Gene, Genetic Mutation, Nacrolepsie, Short Sleep, Short Sleep Gene, Thasso Post, Theragenomic Medicine, Transcriptional Repressor, Wakefulness, β1-Adrenergic Receptor

Variables of prospective response rates of PD-1/PD-L1 based therapies across cancers

Posted on August 28, 2019 by by

thassodotcom Posted in Genetic Background, Genetic Predisposition, New Research, On The Horizon, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

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Tags: Colitis, Fatal Toxic Event, Hepatitis, Immune-Related Adverse Events (irAEs), Ipilimumab [Yervoy], Myocarditis, Neurotoxic Effects, Overall Response Rate (ORR), Pembrolizumab [Keytruda], Pneumonitis, Programmed Cell Death 1 Protein (PD-1), Programmed Cell Death 1 Protein Ligand 1 (PD-L1), Thasso Post, Theragenomic Medicine, These, Tumor Agnostic Therapy

Black people with natural blonde hair – Everything is possible in genetics

Posted on August 7, 2019 by by

thassodotcom Posted in Allelic Variant, Ethnicity, Genetic Predisposition, New Research, Personomics, Thasso Post, Theragenomic Medicine No Comments ↓

August 07, 2019 – Blonde hair is a rare human phenotype found almost exclusively in Europe and Oceania. Human pigmentation varies considerably within and among populations and is a function of both variation in exposure to ultraviolet radiation (UVR) and the type and quantity of melanin produced in melanocytes and keratinocytes.

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Tags: African Ancestry, Allelic Variant, Autosomal Recessive, Blonde Hair, Genetic Predisposition, Genetic Variant, Genome Wide Association Study (GWA), Genotyp [Homozygot], Inheritance, Melanesian People, Melanin, Oceania, Solomon Islands, Thasso Post, Theragenomics Medicine, Tyrosinase-Related Protein 1, TYRP1 Gene, Years Before Present (YBP)

ZRANB3 in African Populations: New Type 2 Diabetes risk locus identified

Posted on August 3, 2019 by by

thassodotcom Posted in Ethnicity, Genetic Background, Genetic Predisposition, Genetic Susceptibility, Personalized Medicine, Personomics, Thasso Post, Theragenomic Medicine No Comments ↓

August 03, 2019 – Africa is considered the original cradle of all humanity, to which all humans can trace their genetic origin. This may be very interesting in the context of diseases that are due to genetic predispositions both in todays African populations and in all the populations descendant of African origin worldwide.

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Tags: 1000 Genomes Project (1KGP), African Population, Genome Aggregation Database (GnomAD), Risk Locus, T2D, Thasso Post, Theragenomic Medicine, Type 2 Diabetes, ZRANB3 Gene

Risk loci for post-traumatic stress disorder (PTSD)

Posted on August 1, 2019 by by

thassodotcom Posted in Allelic Variant, Ethnicity, Genetic Background, Genetic Predisposition, New Research, Thasso Post, Theragenomic Medicine No Comments ↓

August 01, 2019 – Post-Traumatic Stress Disorder (PTSD) is a mental disorder that can develop after a person is exposed to a traumatic event, such as sexual assault, warfare, traffic collisions, or other threats on a person’s life. Symptoms may include disturbing thoughts,

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