Blog Archives

Is there pre-emptive genotyping to avoid adverse drug effects (ADRs)?

November 20, 2022 – The genetics of drug side-effects. Some 95% of people have a gene variant that affects their response to at least one drug. Treating physicians, clinical researchers, and affected patients know all to well the serious problems that unwanted adverse effects of medications (usually referred to as ADRs) can cause.

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Do genes affect our risk for addiction?

November 10, 2022 – Drug addiction is a huge social problem of our todays societies. The problem does not only exist in the USA, but in other countries worldwide as well, with enormous numbers of victims due to alcoholism, smoking, and opioid and illicit drug use.

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Why we want to drink: Are there genes behind it?

October 21, 2022 – Why we want to drink (possibly too much)? And what has that to do with our genes, and why it matters for our alcohol risk? These are some of the question coming out of a recent article in the Journal ” Alcoholism: Clinical &

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Genetic studies of African populations on disease susceptibility and response to vaccines and therapeutics 

September 25, 2022 – Nearly 2000 years ago the Roman scholar and natural philosopher Pliny the Elder wrote in his Natural History: “Ex Africa surgit semper aliquid novi” (from Africa there is always something new). This quote beautifully applies to genetic studies of African populations as they provide a critical resource in the study of genetic risk factors of human disease and to new discoveries.

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Serious lupus: Strong genetic risk factor on its path

August 21, 2022 – Systemic lupus erythematosus (SLE) is a common, incurable autoimmune disease that affects millions of individuals worldwide, with a particularly high prevalence among women. A genetic variant, called HLA-DRB1*03:01, is the greatest risk factor for the condition, which involves inflammation in many vital organs,

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Do genomic regions influence the severity of Covid-19 disease?

August 18, 2022 – The question why certain patients suffer from very severe, even fatal conditions after infections with SARS-CoV-2 has occupied patients, the general population, medical professionals, and the media all alike for some time now. As a basic researcher in the field of genetic susceptibility of patients for the development of very serious adverse,

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Is there rapid management of 500 (rare) genetic diseases?

29 July 2022 – This is a mind-boggling article out of the MedicalXpress news portal, which I present here almost original and unedided. So, all the credentials go to the authors at MedicalXpress. Here the article:

The Rady Children’s Institute for Genomic Medicine (RCIGM) today announced the publication of a study in Nature Communications describing and examining the performance of Genome-to-Treatment (GTRx),

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Blockchain: Genomics instead of bitcoins

21 July 2022 – Blockchain is a digital technology that allows a secure and decentralized record of transactions that is increasingly used for everything from cryptocurrencies to artwork. But blockchain also is entering or is increasingly used in any environment, were individual information is arising and could securely be shared with others.

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Real world theragenomics and personalised medicine

June 23, 2022 – Expansion of pharmacogenetics education agreed as part of lawsuit settlement. This has just been the headline objective of one of the latest blogs from the PharmGKB blogspot, an NIH-funded resource (database) that provides information about how human genetic variation affects responses of individual patients to medications.

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Rare APOE genetic variants reduce Alzheimer’s risk

13 June 2022 – Sometimes, patients genetics can be bewildering and/or unjust. Common belief with patients and the general public would be that genetic variants would be responsible for causing all kinds of adverse drug reactions (ADR’s) and be at the base of of the susceptibility for the development of very many diseases,

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