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Vemurafenib [Zelboraf] Approved Together with a Companion Diagnostic Test by FDA for Advanced Melanoma in BRAF V600E Positive Patients

August 17, 2011 — The US Food and Drug Administration (FDA) has just approved the oral targeted therapy Vemurafenib [Zelboraf] for the first-line treatment of both metastatic and unresectable melanomas. The drug is specifically indicated for patients with melanoma whose tumors have V600E mutations in the BRAF gene. An estimated 50% of patients with melanoma have this type of BRAF mutation,

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Heart Medication Dronedarone [Multaq]: Risk of Severe Liver Injury

January 14, 2011 – The American Food and Drug Administration (FDA) notified today healthcare professionals and patients about cases of rare, but severe liver injury, including two cases of acute liver failure leading to liver transplant in patients treated with the heart medication Dronedarone [Multaq].

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Sitaxentan [Thelin] to be withdrawn from market worldwide due to cases of unpredictable serious liver injury

December 13, 2010 – We learn today that the European Medicines Agency (EMEA) has been informed of Pfizer’s decision to voluntarily withdraw Sitaxentan [Thelin] from the market worldwide further to new information on two cases of fatal liver injury. Pfizer has also decided to discontinue all ongoing clinical trials.

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Sibutramine [Meridia]: Market Withdrawal Due to Risk of Serious Cardiovascular events

October 08, 2010 – Today, we learn that Abbott Laboratories and FDA notified healthcare professionals and patients about the voluntary market withdrawal of Sibutramine [Meridia], an obesity drug, from the U.S. market because of clinical trial data indicating an increased risk of heart attack and stroke.

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Lamotrigine [Lamictal]: DrugLabel Change Because Risk of Aseptic Meningitis

2010-08-15 – From a recent health safety alert  we learn that  FDA notified healthcare professionals and patients that Lamotrigine [Lamictal], a medication commonly used for seizures in children two years and older, and bipolar disorder in adults, can cause aseptic meningitis. Symptoms of meningitis may include headache,

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Eltrombopag [Promacta]: Portal Venous System Thromboses in Study of Patients With Chronic Liver Disease

May 13, 2010 – The American Food and Drug Administration (FDA) posted yesterday the following Safety Information Text (italic):

GlaxoSmithKline and FDA notified healthcare professionals of a new safety finding in patients with thrombocytopenia due to chronic liver disease treated with Eltrombopag [Promacta],

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European Medicines Agency (EMEA) recommends revocation of marketing authorisation for bufexamac containing medicines.

April 27, 2010 – From an announcement by the EMEA we learn that bufexamac-containing medicines were to be taken off EU markets because of high risk of contact allergies.

The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has recommended that marketing authorisations for bufexamac- containing medicines be revoked.

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  • New COVID-19 related genes—helpful and harmful—found in massive screen October 26, 2020
    Researchers at Yale University and the Broad Institute of MIT and Harvard screened hundreds of millions of cells exposed to the COVID-19 and MERS viruses and identified dozens of genes that both enable the viruses to replicate in cells and also those that seem to slam the door on the virus.
  • Genetic predisposition to increased weight is protective for breast and prostate cancer October 26, 2020
    Although a recent campaign by Cancer Research UK emphasized obesity as a risk factor for cancer on par with smoking, the scientific literature on the relationship between increased weight and cancer risk is not so clear. In a new analysis, researchers from Brunel University London found that increasing weight is causally protective for breast and […]
  • Insights into the genetic architecture of penicillin allergy October 26, 2020
    Researchers announce the first robust evidence for the role of the major histocompatibility complex gene HLA-B in penicillin allergy. To identify genetic risk factors for penicillin allergy, the international team of researchers harnessed self-reported data and the electronic health records of more than 600,000 people, as well as replicating their findings in two independent research […]
  • Breast cancer risk and disease-causing mutations in women over age 65 October 26, 2020
    Women with the onset of breast cancer over age 65 often do not qualify for genetic testing, yet little is known about the frequency of disease-causing mutations in breast cancer predisposition genes in this population. In a new study, researchers investigated the prevalence of disease-causing variants in established breast cancer predisposition genes and estimated the […]
  • Cell-free DNA provides a dynamic window into health October 26, 2020
    Short fragments of cell-free DNA (cfDNA) that circulate in blood, urine, and other biofluids can offer an information-rich window into human physiology and disease. By looking at the methylation markers of cfDNA, researchers can identify the tissue from which the DNA came. A new study used this method to monitor infectious and immune-related diseases, including […]
  • 3D printing the first ever biomimetic tongue surface October 26, 2020
    Scientists have created synthetic soft surfaces with tongue-like textures for the first time using 3D printing, opening new possibilities for testing oral processing properties of food, nutritional technologies, pharmaceutics and dry mouth therapies.
  • Surprised researchers: Number of leopards in northern China on the rise October 26, 2020
    Most of the world's leopards are endangered and generally, the number of these shy and stunning cats is decreasing. However, according to a recent study by a researcher from University of Copenhagen and colleagues from China, leopard populations in northern China are on the mend. Discover why below.
  • Powering the future: new insights into how alkali-metal doped flexible solar cells work October 26, 2020
    A group of scientists from Korea has discovered that the amount of alkali metal introduced into crystals of flexible thin-film solar cells influences the path that charge carriers take to traverse between electrodes, thereby affecting the light-to-electricity conversion efficiency of the solar cell. Given the immense application potential that such solar cells have today, this […]
  • Scientists establish NanDeSyn Database to support international cooperation on industrial microalgae October 26, 2020
    To promote resource sharing and research cooperation for the synthetic biology and molecular breeding of industrial oil-producing microalgae, an international team led by Single-Cell Center (SCC), Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences (CAS), has released the "NanDeSyn Database" (http://www.nandesyn.org).
  • A heart-breast cancer-on-a-chip monitoring system October 26, 2020
    Dual-organ system enables the measurement of cardiac toxicity arising from breast cancer chemotherapy. A collaborative team, which includes a group from the Terasaki Institute for Biomedical Innovation, has developed an organs-on-a-chip system that more widely examines the responses of breast cancer and heart tissues to therapeutic breast cancer drugs.
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