the glocalized network in theragenomic and personalized medicine and the genetics of individual patients safety of drugs
March 01, 2023 – The gene APOE codes for apolipoprotein E (Apo-E), a protein involved in the metabolism of fats in the body of mammals. A subtype is implicated in the Alzheimer’s disease and cardiovascular diseases. Recently, researchers at Stanford University …
APOE Missense Variant Linked to Increased Alzheimer’s Disease Risk in African Americans Read more »
January 08, 2023 – In precision and/or targeted medicine of today, physicians typically start out with the determination of the patients phenotypic expression of a disease (i.e., establish a clinical finding) and then go on into finding out the patients genetic …
Genomic variants traced forward to genetic disorders: A new approach? Read more »
November 20, 2022 – The genetics of drug side-effects. Some 95% of people have a gene variant that affects their response to at least one drug. Treating physicians, clinical researchers, and affected patients know all to well the serious problems that …
Is there pre-emptive genotyping to avoid adverse drug effects (ADRs)? Read more »
September 25, 2022 – Nearly 2000 years ago the Roman scholar and natural philosopher Pliny the Elder wrote in his Natural History: “Ex Africa surgit semper aliquid novi” (from Africa there is always something new). This quote beautifully applies to …
September 21, 2022 – Here, a big bias in genetic research into its applicability on “personalized”, or “precision”, or “theragenomic” medicine is finally addressed and brought forward to all involved in these fields. The problem until now is (and was} that …
13 June 2022 – Sometimes, patients genetics can be bewildering and/or unjust. Common belief with patients and the general public would be that genetic variants would be responsible for causing all kinds of adverse drug reactions (ADR’s) and be at the …
Rare APOE genetic variants reduce Alzheimer’s risk Read more »
09 June 2022 – The individium in general and the patient in the context discussed here, are the phenotype experts on their forms of proper disease they are suffering from. It is not their treating physician, it is not a …
Just a reminder: Thasso and the apomediary patient Read more »
April 30, 2022 – In a very recent report published in PLoS Genetics by Dr. Verma of the Corporal Michael Crescenz VA Medical Center in Philadelphia, Pennsylvania, US, and colleagues, new data from the Veterans Affairs Million Veteran Program (MVP) has …
Genetic links revealed between severe COVID-19 and other diseases Read more »
April 10, 2022 – Sotrovimab, sold under the brand name Xevudy, is a monoclonal antibody that was available under emergency use authorization (EUA) from the FDA and similar urgency authorisations from several drug regulatory agencies worldwide for the treatment of patients …
SARS-CoV-2 Delta Variant: Resistance Mutations after Sotrovimab Use Read more »
October 28 , 2021 – One of the most interessant and still unresolved question in connection with Covid-19 disease is the fact that some patients develop a heavy, if not fatal forms of Covid-19 disease after their infection with SARS-CoV-2 while …
Drivers of severe Covid-19 disease in patients under 50 without comorbidities Read more »