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In Caribbeans cystic fibrosis (CF) is driven by very rare CFTR mutations

Posted on by by Posted in Allelic Variant, Ethnicity, Genetic Predisposition, Genetic Susceptibility, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

November 03, 2019 – Cystic fibrosis (CF) is a lethal, inherited genetic disease affecting more than 70,000 people worldwide. It is usually diagnosed in childhood and causes abnormal buildup of thick mucus in the lungs and digestive tract that leads to trouble breathing,

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Clinical evidence and implementation challenges for pharmacogenomic testing

Posted on by by Posted in Allelic Variant, Genetic Background, Genetic Predisposition, Genetic Susceptibility, Personalized Medicine, Personomics, Pharmacogenetics, Thasso Post, Theragenomic Medicine No Comments ↓

September 18, 2019 – This post is an edited version of parts of a paper that appeared in the Journal of Personalised Medicine (JPM) a week ago und which addresses one of the important topics in connection with the themes of personalised medicine,

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Variables of prospective response rates of PD-1/PD-L1 based therapies across cancers

Posted on by by Posted in Genetic Background, Genetic Predisposition, New Research, On The Horizon, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

August 28, 2019 – Immune checkpoint inhibitor (ICI) therapy is a form of cancer immunotherapy. The therapy targets immune checkpoints, key regulators of the immune system that when stimulated can dampen the immune response to an immunologic stimulus.

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ZRANB3 in African Populations: New Type 2 Diabetes risk locus identified

Posted on by by Posted in Ethnicity, Genetic Background, Genetic Predisposition, Genetic Susceptibility, Personalized Medicine, Personomics, Thasso Post, Theragenomic Medicine No Comments ↓

August 03, 2019 – Africa is considered the original cradle of all humanity, to which all humans can trace their genetic origin. This may be very interesting in the context of diseases that are due to genetic predispositions both in todays African populations and in all the populations descendant of African origin worldwide.

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The phenotype broker: Blockchain and patient phenotype

Posted on by by Posted in New Research, On The Horizon, Personalized Medicine, Personomics, Targeted Therapy, Thasso Post, Theragenomic Medicine No Comments ↓

July 26, 2019 – “Blockchains for secure digitized medicine”. This is the title of a very interesting and important article in the Journal of Personalised Medine (JPM) as of May 28, 2019.

Blockchain as an emerging technology (particularly around the hype on Bitcoins) has been gaining in popularity,

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Status of genetics behind male infertility

Posted on by by Posted in Genetic Background, Genetic Predisposition, Genetic Susceptibility, New Research, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

June 20, 2019 – Male infertility is a serious treat in very many relations. While a priori, male infertility does not affect the physical health of the afflicted, it may very much affect the psychological health of the individual, and that of couples too.

In recent years,

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Gene therapy: Zolgensma to treat spinal muscular atrophy

Posted on by by Posted in Children, Genetic Predisposition, New Drug Approval, Personalized Medicine, Targeted Therapy, Thasso Post, Theragenomic Medicine No Comments ↓

May 29, 2019 – Spinal muscular atrophy (SMA) is a group of neuromuscular disorders that result in the loss of motor neurons and progressive muscle wasting. The severity of symptoms and age of onset varies by the type. Some types are apparent at or before birth while others are not apparent until adulthood. 

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Cholangiocarcinoma: Diabetes Drugs In DPP-4 Inhibitor Class Associated With Doubled Risk

Posted on by by Posted in Adverse Drug Reaction [ADR], Genetic Background, Genetic Predisposition, Genetic Susceptibility, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

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CRISPR/Cas9 for the Treatment of Duchenne Muscular Dystrophy: Prime time already?

Posted on by by Posted in Adverse Drug Reaction [ADR], Allelic Variant, Children, Clinical Development, Congenital, Gene Therapy, Genetic Predisposition, In The Press, Personalized Medicine, Rare Diseases, Thasso Post, Theragenomic Medicine No Comments ↓

December 12, 2018 – The application of CRISPR/Cas9 based molecular technology in the field of gene editing (or genome editing) has recently had its exploded limelight exposure for a couple of reasons. The question arises if this exposure is earned or somewhat premature.

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Living theragenomic medicine: Direct to consumer test for metabolism of drugs FDA approved

Posted on by by Posted in Genetic Background, Genetic Predisposition, Personalized Medicine, Pharmacogenetics, Regulatory Approval, Targeted Therapy, Thasso Post, Theragenomic Medicine No Comments ↓
November 08, 2018 –  The American Food and Drug Administration (FDA) has just authorized the first direct-to-consumer test for detecting genetic variants in genes that may govern the metabolism of drugs in individual patients.

Thus, FDA permits marketing, with special controls,

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RSS random genetics

RSS random science

  • New study shows how cancer survivors develop opioid addictions November 22, 2019
    Opioids play an important role in how cancer patients manage pain, but the ongoing opioid epidemic has raised concerns about their potential for abuse. A new study in the Journal of the National Cancer Institute reveals that several factors are associated with a risk for persistent opioid use, including younger age, white race, unemployment at […]
  • Lack of sleep may explain why poor people get more heart disease November 22, 2019
    Insufficient sleep is one reason why disadvantaged groups have more heart disease. That's the finding of a study published today in Cardiovascular Research, a journal of the European Society of Cardiology (ESC).
  • Women raised in poor neighborhoods face an increased risk of intimate partner violence November 21, 2019
    Women who spend longer periods of their early lives in less affluent neighbourhoods are at greater risk of experiencing violence during their early adulthoods at the hands of their intimate partners, finds a new study published in Epidemiology.
  • A review of single molecule-based electronic devices November 21, 2019
    In a paper to be published in the forthcoming issue in NANO, a group of researchers from the Shenyang Jianzhu University in China provide an overview of single molecule electronic devices, including molecular electronic devices and electrode types. Future challenges are described in the hopes of attracting more experts from different fields to participate in […]
  • Wolfe Creek Crater younger than previously thought November 21, 2019
    Wolfe Creek Crater, one of the world's largest meteorite craters, is much younger than previously thought.
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