Personalized Medicine

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Abdominal aortic aneurysm: Genetic scoring can identify more men at risk

Posted on May 7, 2020 by by

Joseph Gut - thasso Posted in Genetic Predisposition, Genetic Susceptibility, New Research, On The Horizon, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

May 07, 2020 – Abdominal aortic aneurysm (AAA) is a localized enlargement of the abdominal aorta such that the diameter is greater than 3 cm or more than 50% larger than normal. AAAs usually cause no symptoms, except during rupture.

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Tags: Abdominal Aortic Aneurysm (AAA), Aortic Aneurysm, Aortic Aneurysm Rupture, Ehlers-Danlos Syndrome, Fatal Medical Event, Genetic Predisposition, Increased Risk Of Death, Marfan Syndrome, Medical Emergency, Thasso Post, Theragenomic Medicine

Are Asians at higher genetic risk of serious adverse events to common medications?

Posted on March 10, 2020 by by

Joseph Gut - thasso Posted in Adverse Drug Reaction [ADR], Allelic Variant, Ethnicity, Genetic Predisposition, Personalized Medicine, Thasso Post, Theragenomic Medicine 1 Comment ↓

March 10, 2020 – A widespread assumption is, the people of Asian descent are more prone to serious, sometimes deadly adverse drug reactions, even when taking rather common medications prescribed for gout through to depression. In the ages of genetics and precision medicine, the question then comes up if Asian people could be at such heightened risk because of underlying particular genetic factors.…

Tags: Adverse Drug Reaction (ADR), Adverse Event, Allopurinol (Zyloprim), American Food & Drug Administration (FDA), Asian Population, Carbamazepine [Tegretol], Clinical Pharmacogenetics Implementation Consortium (CPIC), DRESS Syndrome, HLA-B*15:02 Allele, HLA-B*5801 Allele, PharmGKB, Stevens Johnson Syndrome [SJS], Thasso Post, Theragenomic Medicine, Toxic Epidermal Necrolysis (TEN)

The phenotype broker: Blockchain and patient phenotype

Posted on July 26, 2019 by by

Joseph Gut - thasso Posted in New Research, On The Horizon, Personalized Medicine, Personomics, Targeted Therapy, Thasso Post, Theragenomic Medicine No Comments ↓

July 26, 2019 – “Blockchains for secure digitized medicine”. This is the title of a very interesting and important article in the Journal of Personalised Medine (JPM) as of May 28, 2019.

Blockchain as an emerging technology (particularly around the hype on Bitcoins) has been gaining in popularity,

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Tags: Allelic Variants, Apomediary Patient, Bitcoin, Blockchain, Digital Medicine, Electronic Medical Records (EMR), Free Health Data Market (FHDM), Genetic Variants, Genetics, Genotypes, Journal of Personalised Medine (JPM), Patient Phenotype, Personalized Medicine, Phenotype, Phenotype Broker, Thasso Post, Theragenomic Medicine, Third Trusted Party (TTP)

Three idiopathic pulmonary fibrosis (IPF)-associated genes newly identified

Posted on March 5, 2020 by by

Joseph Gut - thasso Posted in Gene Expression, Genetic Background, Genetic Susceptibility, New Research, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

March 05, 2020 – Idiopathic pulmonary fibrosis (IPF) is a type of chronic scarring lung disease characterized by a progressive and irreversible decline in lung function. Symptoms typically include gradual onset of shortness of breath and a dry cough.

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Tags: DEPTOR Gene, Idiopathic Pulmonary Fibrosis (IPF), KIF15 Gene, Lung Disease, MAD1L1 Gene, Thasso Post, Theragenomic Medicine

Heart disease prediction by traditional risk factors as good as with an exhaustive genetic test

Posted on February 20, 2020 by by

Joseph Gut - thasso Posted in Genetic Background, Genetic Predisposition, Genetic Susceptibility, Personalized Medicine, Personomics, Thasso Post, Theragenomic Medicine No Comments ↓

February 20, 2020 – Traditional cardiovascular risk factors often assessed in an annual physical, such as blood pressure, cholesterol levels, diabetes, and smoking status, may at least be as valuable in predicting who will develop coronary heart disease (CHD) as a sophisticated genetic test that surveys millions of different points in DNA,

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Tags: Atherosclerosis, Atherosclerosis Risk in Communities (ARIC), Blood Pressure, Cholesterol Level, Clinical Phenotype, Coronary Heart Disease (CHD), Diabetes, DNA, Genetic Background, Genetic Testing, Genetic Variation, Heart Attack, Multi-Ethnic Study of Atherosclerosis (MESA), Myocardial Infarction, Prospective Risk Prediction, Smoking, Smoking Status, Thasso Post, Traditional Risk Factor

The Apomediary [Patient Expert] and Personalized Medicine: A Commentary

Posted on June 22, 2014 by by

Joseph Gut - thasso Posted in On The Horizon, Personalized Medicine, Thasso Post, Theragenomics No Comments ↓

June 22, 2014 – The individuum (i.e., patient) is the phenotype expert on her/his individualized form of proper disease she/he is suffering from. It is not her/his treating physician, it is not a regulatory person concerned with the safety and efficacy of the medication geared towards treating her/his condition,

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Tags: Apomediary, Collective Wisdom, Confounding Factors, Crowdsourcing, Fellow Patient, Genetic Background, Genotype, Health Kit, Molecular Background, Patient Subgroup, Personalized Medicine, Phenotype, Social Network, Thasso Post, Wearable Devices

In Caribbeans cystic fibrosis (CF) is driven by very rare CFTR mutations

Posted on November 3, 2019 by by

Joseph Gut - thasso Posted in Allelic Variant, Ethnicity, Genetic Predisposition, Genetic Susceptibility, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

November 03, 2019 – Cystic fibrosis (CF) is a lethal, inherited genetic disease affecting more than 70,000 people worldwide. It is usually diagnosed in childhood and causes abnormal buildup of thick mucus in the lungs and digestive tract that leads to trouble breathing,

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Tags: Caribbean Descent, Caucasian Descent, CFTR Allelic Variant, CFTR Gene, CFTR Gene Mutations, Cystic Fibrosis (CF), Ethnic Health Inequality, p.Phe508del, Thasso Post

Clinical evidence and implementation challenges for pharmacogenomic testing

Posted on September 18, 2019 by by

Joseph Gut - thasso Posted in Allelic Variant, Genetic Background, Genetic Predisposition, Genetic Susceptibility, Personalized Medicine, Personomics, Pharmacogenetics, Thasso Post, Theragenomic Medicine No Comments ↓

September 18, 2019 – This post is an edited version of parts of a paper that appeared in the Journal of Personalised Medicine (JPM) a week ago und which addresses one of the important topics in connection with the themes of personalised medicine,

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Tags: All of Us Project, Canadian Association of Genetic Counsellors, Clinical Pharmacogenetics Implementation Consortium (CPIC), Direct To Consumer Genetic Testing (DTCGT), Dutch Pharmacogenetics Working Group (DPWG), Genetic Testing, Next Generation Sequencing (NGS), Pharmacogenomics, PharmGKB, PREDICT Program, Right Dose, Right Drug, Right Time Protocol (RIGHT Protocol), Thasso Post, Theragenomic Medicine, Ubiquitous Pharmacogenomics Project (UPGX), US National Society of Genetic Counselors

Variables of prospective response rates of PD-1/PD-L1 based therapies across cancers

Posted on August 28, 2019 by by

Joseph Gut - thasso Posted in Genetic Background, Genetic Predisposition, New Research, On The Horizon, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

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Tags: Colitis, Fatal Toxic Event, Hepatitis, Immune-Related Adverse Events (irAEs), Ipilimumab [Yervoy], Myocarditis, Neurotoxic Effects, Overall Response Rate (ORR), Pembrolizumab [Keytruda], Pneumonitis, Programmed Cell Death 1 Protein (PD-1), Programmed Cell Death 1 Protein Ligand 1 (PD-L1), Thasso Post, Theragenomic Medicine, These, Tumor Agnostic Therapy

ZRANB3 in African Populations: New Type 2 Diabetes risk locus identified

Posted on August 3, 2019 by by

Joseph Gut - thasso Posted in Ethnicity, Genetic Background, Genetic Predisposition, Genetic Susceptibility, Personalized Medicine, Personomics, Thasso Post, Theragenomic Medicine No Comments ↓

August 03, 2019 – Africa is considered the original cradle of all humanity, to which all humans can trace their genetic origin. This may be very interesting in the context of diseases that are due to genetic predispositions both in todays African populations and in all the populations descendant of African origin worldwide.

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Tags: 1000 Genomes Project (1KGP), African Population, Genome Aggregation Database (GnomAD), Risk Locus, T2D, Thasso Post, Theragenomic Medicine, Type 2 Diabetes, ZRANB3 Gene

David Walliams on Is genetic testing of value for ALS patients?: “CURED FROM GENITAL HERPES More than 5 years ago I was in pain with this deadly herpes virus, A few…” Nov 7, 16:08
Raul Malkovic on Is genetic testing of value for ALS patients?: “HOW MY WIFE GOT CURED FROM ALS Below is how i got a cure for my wife who suffered from Amyotrophic Lateral Sclerosis…” Nov 6, 21:18
Pamela Erickson on Is genetic testing of value for ALS patients?: “My husband was diagnosed with ALS (amyotrophic lateral sclerosis) when he was 63 years old 4 years ago. The Rilutek…” Aug 13, 13:04
thassodotcom on Unlucky women with BIA-ALCL: An update: “The Therapeutic Goods Agency (TGA) of Australia has just issued a hazard alert concerning the risk of breast implant-associated anaplastic…” Aug 4, 09:17
thassodotcom on Tofacitinib (Xeljanz): Dangers of blood clots in the lungs and of death: “According to its Drug Safety Communication from 07/26/2019, the FDA has approved new warnings about an increased risk of blood…” Aug 4, 08:40

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Blog Archives

Abdominal aortic aneurysm: Genetic scoring can identify more men at risk

Are Asians at higher genetic risk of serious adverse events to common medications?

The phenotype broker: Blockchain and patient phenotype

Three idiopathic pulmonary fibrosis (IPF)-associated genes newly identified

Heart disease prediction by traditional risk factors as good as with an exhaustive genetic test

In Caribbeans cystic fibrosis (CF) is driven by very rare CFTR mutations

Clinical evidence and implementation challenges for pharmacogenomic testing

ZRANB3 in African Populations: New Type 2 Diabetes risk locus identified

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Increased Risk Of Aneurysms And Artery Dissections With VEGF Inhibitors

Study looks at genetic background of healthy people who develop severe Covid-19 illness

Diagnoses for children with rare genetic diseases by 3-D facial scans

Host factors may influence Covid-19 severity more than viral genetic variation

Abdominal aortic aneurysm: Genetic scoring can identify more men at risk

Besides the now approved remdesivir: Emerging options to treat Covid-19

Could DNA testing help the most seriously affected Covid-19 patients?

Klotho’s role in some patients with Alzheimer’s disease revealed?

First therapy for children with debilitating NF-1 approved in the USA

Inherited mutation in ELP1 predisposes children to medulloblastoma

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