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Are Asians at higher genetic risk of serious adverse events to common medications?

Posted on by by Posted in Adverse Drug Reaction [ADR], Allelic Variant, Ethnicity, Genetic Predisposition, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

March 10, 2020 – A widespread assumption is, the people of Asian descent are more prone to serious, sometimes deadly adverse drug reactions, even when taking rather common medications prescribed for gout through to depression. In the ages of genetics and precision medicine, the question then comes up if Asian people could be at such heightened risk because of underlying particular genetic factors.…

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Three idiopathic pulmonary fibrosis (IPF)-associated genes newly identified

Posted on by by Posted in Gene Expression, Genetic Background, Genetic Susceptibility, New Research, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

March 05, 2020 – Idiopathic pulmonary fibrosis (IPF) is a type of chronic scarring lung disease characterized by a progressive and irreversible decline in lung function. Symptoms typically include gradual onset of shortness of breath and a dry cough.

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Heart disease prediction by traditional risk factors as good as with an exhaustive genetic test

Posted on by by Posted in Genetic Background, Genetic Predisposition, Genetic Susceptibility, Personalized Medicine, Personomics, Thasso Post, Theragenomic Medicine No Comments ↓
February 20, 2020 – Traditional cardiovascular risk factors often assessed in an annual physical, such as blood pressure, cholesterol levels, diabetes, and smoking status, may at least be as valuable in predicting who will develop coronary heart disease (CHD) as a sophisticated genetic test that surveys millions of different points in DNA,

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In Caribbeans cystic fibrosis (CF) is driven by very rare CFTR mutations

Posted on by by Posted in Allelic Variant, Ethnicity, Genetic Predisposition, Genetic Susceptibility, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

November 03, 2019 – Cystic fibrosis (CF) is a lethal, inherited genetic disease affecting more than 70,000 people worldwide. It is usually diagnosed in childhood and causes abnormal buildup of thick mucus in the lungs and digestive tract that leads to trouble breathing,

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Clinical evidence and implementation challenges for pharmacogenomic testing

Posted on by by Posted in Allelic Variant, Genetic Background, Genetic Predisposition, Genetic Susceptibility, Personalized Medicine, Personomics, Pharmacogenetics, Thasso Post, Theragenomic Medicine No Comments ↓

September 18, 2019 – This post is an edited version of parts of a paper that appeared in the Journal of Personalised Medicine (JPM) a week ago und which addresses one of the important topics in connection with the themes of personalised medicine,

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Variables of prospective response rates of PD-1/PD-L1 based therapies across cancers

Posted on by by Posted in Genetic Background, Genetic Predisposition, New Research, On The Horizon, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

August 28, 2019 – Immune checkpoint inhibitor (ICI) therapy is a form of cancer immunotherapy. The therapy targets immune checkpoints, key regulators of the immune system that when stimulated can dampen the immune response to an immunologic stimulus.

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ZRANB3 in African Populations: New Type 2 Diabetes risk locus identified

Posted on by by Posted in Ethnicity, Genetic Background, Genetic Predisposition, Genetic Susceptibility, Personalized Medicine, Personomics, Thasso Post, Theragenomic Medicine No Comments ↓

August 03, 2019 – Africa is considered the original cradle of all humanity, to which all humans can trace their genetic origin. This may be very interesting in the context of diseases that are due to genetic predispositions both in todays African populations and in all the populations descendant of African origin worldwide.

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The phenotype broker: Blockchain and patient phenotype

Posted on by by Posted in New Research, On The Horizon, Personalized Medicine, Personomics, Targeted Therapy, Thasso Post, Theragenomic Medicine No Comments ↓

July 26, 2019 – “Blockchains for secure digitized medicine”. This is the title of a very interesting and important article in the Journal of Personalised Medine (JPM) as of May 28, 2019.

Blockchain as an emerging technology (particularly around the hype on Bitcoins) has been gaining in popularity,

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Status of genetics behind male infertility

Posted on by by Posted in Genetic Background, Genetic Predisposition, Genetic Susceptibility, New Research, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

June 20, 2019 – Male infertility is a serious treat in very many relations. While a priori, male infertility does not affect the physical health of the afflicted, it may very much affect the psychological health of the individual, and that of couples too.

In recent years,

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Gene therapy: Zolgensma to treat spinal muscular atrophy

Posted on by by Posted in Children, Genetic Predisposition, New Drug Approval, Personalized Medicine, Targeted Therapy, Thasso Post, Theragenomic Medicine No Comments ↓

May 29, 2019 – Spinal muscular atrophy (SMA) is a group of neuromuscular disorders that result in the loss of motor neurons and progressive muscle wasting. The severity of symptoms and age of onset varies by the type. Some types are apparent at or before birth while others are not apparent until adulthood. 

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RSS random genetics

RSS random science

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    To truly understand an animal species is to observe its behavior and social networks in the wild. With new technology described today (April 2) in PLOS Biology, researchers are able to track tiny animals that divide their time between flying around in the sky and huddling together in caves and hollow trees -- by attaching […]
  • A friendlier way to deal with nitrate pollution April 2, 2020
    Learning from nature, scientists from the Center for Sustainable Resource Science in Japan and the Korean Basic Science Institute (KBSI) have found a catalyst that efficiently transforms nitrate into nitrite -- an environmentally important reaction -- without requiring high temperature or acidity, and now have identified the mechanism that makes this efficiency possible.
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    Research on the effects of climate change on armed violence have previously been open to interpretation but new study shows climate-related disasters enhance armed conflict risks.
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    Sustainable energy storage is in great demand. Researchers at Uppsala University have therefore developed an all-organic proton battery that can be charged in a matter of seconds. The battery can be charged and discharged over 500 times without any significant loss of capacity. Their work has been published in the scientific journal Angewandte Chemie.
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