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Home › Archive for Personalized Medicine

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Risk of Bullous Pemphigoid with Type 2 Diabetes Drugs

Posted on August 12, 2018 by by

thassodotcom Posted in Adverse Drug Reaction [ADR], Allelic Variant, Genetic Susceptibility, In The Press, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

August 12, 2018 – Findings from a retrospective case-control study were published online August 8, 2018, in JAMA Dermatology indicate that the use of certain dipeptidyl peptidase 4 (DPP-4) inhibitor drugs are associated with a small but significantly elevated risk for developing bullous pemphigoid,

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Ivosidenib (Tibsovo) for AML-patients with IDH1-mutations

Posted on July 22, 2018 by by

thassodotcom Posted in Allelic Variant, Companion Test, New Drug Approval, Personalized Medicine, Regulatory Approval, Targeted Therapy, Thasso Post, Theragenomic Medicine No Comments ↓

July 22, 2018 – The American Food and Drug Administration (FDA) just approved Ivosidenib (Tibsovo) for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) who have a specific genetic mutation in the IDH1 gene.

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Coffee Drinking, Genetic Variation, and Mortality

Posted on July 7, 2018 by by

thassodotcom Posted in Genetic Background, New Research, Personalized Medicine, Thasso Post, Theragenomic Medicine 1 Comment ↓

July 07, 2018 – A very recent paper by Loftfield E. et al., published online in JAMA Intern. Med. on July 02, looked at the association of coffee drinking with mortality by genetic variation in caffeine metabolism.

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Breast cancer: Multigene sequencing replaces BRCA tests

Posted on May 15, 2018 by by

thassodotcom Posted in Genetic Background, Genetic Predisposition, Genetic Susceptibility, New Research, Personalized Medicine, Targeted Therapy, Thasso Post No Comments ↓

May 15, 2018 –An increasing number of women who are diagnosed with breast cancer are opting for multigene sequencing instead of the more limited testing for only BRCA1/ BRCA2 mutations, according to a new report.

The findings come from the ICanCAre study,

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Ethnic disparities in the occurrence of prostate cancer

Posted on May 11, 2018 by by

thassodotcom Posted in Ethnicity, Gene Expression, In The Press, New Research, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

May 10, 2018 – A seemingly higher incidence of prostate cancer and resulting fatalities in African-American men than in European-Amcerican men has been noted for quite some time. New research published in Molecular Oncology may help explain why African American men are at a higher risk of being diagnosed with prostate cancer and a higher risk of dying from the disease compared with European American men.

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Heart attacks and stroke: The risk of DPP-4 anti-diabetes drugs

Posted on May 6, 2018 by by

thassodotcom Posted in Adverse Drug Reaction [ADR], Personalized Medicine, Thasso Post, Theragenomic Medicine 1 Comment ↓

May 06, 2018 – In April 2016 the American Food and Drug Administration (FDA) took regulatory action by mandating label changes with new warnings about an increased risk of heart failure for new diabetes medicines in the dipeptidyl peptidase-4 (DPP-4) inhibitor drug class, including Saxagliptin (Onglyza),

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Dabrafenib/Trametinib-Combo approved for BRAF-positive anaplastic thyroid cancer

Posted on May 5, 2018 by by

thassodotcom Posted in Allelic Variant, New Drug Approval, New Indication Approval, Personalized Medicine, Regulatory Announcement, Targeted Therapy, Thasso Post, Theragenomic Medicine No Comments ↓

May 05, 2018 – The American Food and Drug Administration (FDA) just approved the combination of Dabrafenib (Tafinlar)/Trametinib (Mekinist) to be administered together for the treatment of anaplastic thyroid cancer (ATC) that cannot be removed by surgery or has spread to other parts of the body (metastatic),

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Chinese arrhythmia in traditional medicine

Posted on May 4, 2018 by by

thassodotcom Posted in Adverse Drug Reaction [ADR], In The Press, New Research, On The Horizon, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

May 04, 2018 – All natural is healthy. This is a common belief for many, particularly when shopping for alternative medicines and dietary supplements. For many, however, the contrary might be fatally true.

As a point in case, new research shows, that substances in Traditional Chinese Medicine (TCM) can cause severe cardiac arrhythmia.

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Direct-to-Consumer Genetic Testing: Are Patients Ready?

Posted on March 30, 2018 by by

thassodotcom Posted in Genetic Background, Genetic Predisposition, Genetic Susceptibility, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

March 31, 2018 – Are patients ready for direct-to-consumer genetic testing? This was the very important and central question that came up in the article by Matt Smith on Medscape, published March 29, 2018.

Since thasso is all about theragenomic and personalized medicine and individualized drug safety (i.e.

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Breast Cancer: Performance of prognostic signatures

Posted on February 17, 2018 by by

thassodotcom Posted in Clinical Development, Diagnostic, Gene Expression, New Research, Personalized Medicine, Targeted Therapy, Thasso Post, Theragenomic Medicine No Comments ↓

February 17, 2018 – In a new study, published in JAMA Oncology online on February 15, 2018, a comparison of the performance of 6 prognostic signatures for estrogen receptor (ER) –positive breast cancer was performed in a secondary analysis of a randomized clinical trial.

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thasso: recent posts

Diabetes: No end to SGLT2-inhibitor drugs side effects September 1, 2018
Patisiran (Onpattro): First targeted RNA-based therapy approved to treat hATTR August 13, 2018
Risk of Bullous Pemphigoid with Type 2 Diabetes Drugs August 12, 2018
Ivosidenib (Tibsovo) for AML-patients with IDH1-mutations July 22, 2018
Coffee Drinking, Genetic Variation, and Mortality July 7, 2018
Erenumab-Aooe (Aimovig): Novel preventive treatment for migraine approved June 29, 2018
Epidiolex: Marijuana-derived drug to treat rare forms of epilepsy June 26, 2018
Winning the FIFA World-Cup: Is it all genetic? June 24, 2018
Neural tube defects with Dolutegravir-based HIV medications May 21, 2018
Breast cancer: Multigene sequencing replaces BRCA tests May 15, 2018

thasso: recent comments

minecraft on X-linked Hypophosphatemia: Burosumab (Crysvita) to the rescue
minecraft on Olodaterol [Striverdi Respimat] approved to treat chronic obstructive pulmonary disease
minecraft on Dulaglutide [Trulicity], a glucagon-like peptide-1 (GLP-1) receptor agonist, approved for the treatment of type 2 diabetes
minecraft on X-linked Hypophosphatemia: Burosumab (Crysvita) to the rescue
minecraft on Full Scale “Active Surveillance”: The Sentinel System

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FDA press releases

Statement from FDA Commissioner Scott Gottlieb, M.D., on the FDA’s ongoing efforts to prevent foodborne outbreaks of <i>Cyclospora</i> September 18, 2018
FDA takes important steps to encourage appropriate and rational prescribing of opioids through final approval of new safety measures governing the use of immediate-release opioid analgesic medications September 18, 2018
Statement from FDA Commissioner Scott Gottlieb, M.D., on launch of ‘The Real Cost’ Youth E-Cigarette Prevention Campaign amid evidence of sharply rising use among kids September 18, 2018
FDA launches new, comprehensive campaign to warn kids about the dangers of e-cigarette use as part of agency’s Youth Tobacco Prevention Plan, amid evidence of sharply rising use among kids September 18, 2018
FDA approves device for treatment of acute coronary artery perforations September 14, 2018

FDA MedWatch

SGLT2(sodium-glucose cotransporter-2) Inhibitors for Diabetes: Drug Safety Communication - Regarding Rare Occurrences of a Serious Infection of the Genital Area
Temporary Total Artificial Heart Companion 2 Driver System by SynCardia Systems: Letter to Health Care Providers - Risk of Mortality and Stroke
Risks Associated with Use of Rupture of Membranes Tests - Letter to Health Care Providers
Zithromax, Zmax (azithromycin): FDA Warning - Increased Risk of Cancer Relapse With Long-Term Use After Donor Stem Cell Transplant
Valsartan-Containing Products: Update Health Professional and Consumer on Recent Recalled Products

More Feeds

News and press releases: Portugal to also benefit from EU-US mutual recognition agreement for inspections
Source: EMA NewsPublished on 2018-09-20
Synthetic organelle shows how tiny puddle-organs in our cells work
Source: EurekaPublished on 2018-09-20
To improve auto coatings, new tests do more than scratch the surface
Source: EurekaPublished on 2018-09-20
ACA health insurance ads targeted younger, healthier consumers from 2013 to 2016
Source: EurekaPublished on 2018-09-20
Neutrons produce first direct 3D maps of water during cell membrane fusion
Source: EurekaPublished on 2018-09-20
Smart pills dumb down medical care, experts warn
Source: EurekaPublished on 2018-09-20
Genomic dark matter activity connects Parkinson’s and psychiatric diseases
Source: EurekaPublished on 2018-09-20
Study: Commitment to democratic values predict climate change concern
Source: EurekaPublished on 2018-09-20

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