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Ivosidenib (Tibsovo) for AML-patients with IDH1-mutations

Posted on July 22, 2018 by by

thassodotcom Posted in Allelic Variant, Companion Test, New Drug Approval, Personalized Medicine, Regulatory Approval, Targeted Therapy, Thasso Post, Theragenomic Medicine No Comments ↓

July 22, 2018 – The American Food and Drug Administration (FDA) just approved Ivosidenib (Tibsovo) for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) who have a specific genetic mutation in the IDH1 gene.

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Coffee Drinking, Genetic Variation, and Mortality

Posted on July 7, 2018 by by

thassodotcom Posted in Genetic Background, New Research, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

July 07, 2018 – A very recent paper by Loftfield E. et al., published online in JAMA Intern. Med. on July 02, looked at the association of coffee drinking with mortality by genetic variation in caffeine metabolism.

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Breast cancer: Multigene sequencing replaces BRCA tests

Posted on May 15, 2018 by by

thassodotcom Posted in Genetic Background, Genetic Predisposition, Genetic Susceptibility, New Research, Personalized Medicine, Targeted Therapy, Thasso Post No Comments ↓

May 15, 2018 –An increasing number of women who are diagnosed with breast cancer are opting for multigene sequencing instead of the more limited testing for only BRCA1/ BRCA2 mutations, according to a new report.

The findings come from the ICanCAre study,

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Ethnic disparities in the occurrence of prostate cancer

Posted on May 11, 2018 by by

thassodotcom Posted in Ethnicity, Gene Expression, In The Press, New Research, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

May 10, 2018 – A seemingly higher incidence of prostate cancer and resulting fatalities in African-American men than in European-Amcerican men has been noted for quite some time. New research published in Molecular Oncology may help explain why African American men are at a higher risk of being diagnosed with prostate cancer and a higher risk of dying from the disease compared with European American men.

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Heart attacks and stroke: The risk of DPP-4 anti-diabetes drugs

Posted on May 6, 2018 by by

thassodotcom Posted in Adverse Drug Reaction [ADR], Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

May 06, 2018 – In April 2016 the American Food and Drug Administration (FDA) took regulatory action by mandating label changes with new warnings about an increased risk of heart failure for new diabetes medicines in the dipeptidyl peptidase-4 (DPP-4) inhibitor drug class, including Saxagliptin (Onglyza),

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Dabrafenib/Trametinib-Combo approved for BRAF-positive anaplastic thyroid cancer

Posted on May 5, 2018 by by

thassodotcom Posted in Allelic Variant, New Drug Approval, New Indication Approval, Personalized Medicine, Regulatory Announcement, Targeted Therapy, Thasso Post, Theragenomic Medicine No Comments ↓

May 05, 2018 – The American Food and Drug Administration (FDA) just approved the combination of Dabrafenib (Tafinlar)/Trametinib (Mekinist) to be administered together for the treatment of anaplastic thyroid cancer (ATC) that cannot be removed by surgery or has spread to other parts of the body (metastatic),

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Chinese arrhythmia in traditional medicine

Posted on May 4, 2018 by by

thassodotcom Posted in Adverse Drug Reaction [ADR], In The Press, New Research, On The Horizon, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

May 04, 2018 – All natural is healthy. This is a common belief for many, particularly when shopping for alternative medicines and dietary supplements. For many, however, the contrary might be fatally true.

As a point in case, new research shows, that substances in Traditional Chinese Medicine (TCM) can cause severe cardiac arrhythmia.

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Direct-to-Consumer Genetic Testing: Are Patients Ready?

Posted on March 30, 2018 by by

thassodotcom Posted in Genetic Background, Genetic Predisposition, Genetic Susceptibility, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

March 31, 2018 – Are patients ready for direct-to-consumer genetic testing? This was the very important and central question that came up in the article by Matt Smith on Medscape, published March 29, 2018.

Since thasso is all about theragenomic and personalized medicine and individualized drug safety (i.e.

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Breast Cancer: Performance of prognostic signatures

Posted on February 17, 2018 by by

thassodotcom Posted in Clinical Development, Diagnostic, Gene Expression, New Research, Personalized Medicine, Targeted Therapy, Thasso Post, Theragenomic Medicine No Comments ↓

February 17, 2018 – In a new study, published in JAMA Oncology online on February 15, 2018, a comparison of the performance of 6 prognostic signatures for estrogen receptor (ER) –positive breast cancer was performed in a secondary analysis of a randomized clinical trial.

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Placebo: A veritable treatment option

Posted on February 11, 2018 by by

thassodotcom Posted in Genetic Background, Genetic Predisposition, New Research, On The Horizon, Personalized Medicine, Placebo, Thasso Post, Theragenomic Medicine No Comments ↓

February 11, 2018 – Long after cancer treatment ends, many patients continue to deal with one particular symptom that refuses to go away: fatigue. In a new study, researchers have found that the power of placebos, even when fully disclosed to patients, might be harnessed to reduce fatigue in cancer survivors.

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thasso: recent posts

Ivosidenib (Tibsovo) for AML-patients with IDH1-mutations July 22, 2018
Coffee Drinking, Genetic Variation, and Mortality July 7, 2018
Erenumab-Aooe (Aimovig): Novel preventive treatment for migraine approved June 29, 2018
Epidiolex: Marijuana-derived drug to treat rare forms of epilepsy June 26, 2018
Winning the FIFA World-Cup: Is it all genetic? June 24, 2018
Neural tube defects with Dolutegravir-based HIV medications May 21, 2018
Breast cancer: Multigene sequencing replaces BRCA tests May 15, 2018
New gene variants in depression May 13, 2018
Ethnic disparities in the occurrence of prostate cancer May 11, 2018
Heart attacks and stroke: The risk of DPP-4 anti-diabetes drugs May 6, 2018

thasso: recent comments

Emmanuel Slater on eHealth: Viz.AI Contact App to alert for stroke in patients
chantelle on Is genetic testing of value for ALS patients?
Joseph Gut on Winning the FIFA World-Cup: Is it all genetic?
RUNESCAPE GOLD on X-linked Hypophosphatemia: Burosumab (Crysvita) to the rescue
sex tape videos on Panitumumab (Vectibix) – Rare Cases of Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)

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FDA press releases

Statement from FDA Commissioner Scott Gottlieb, M.D., on manufacturer announcement to halt Essure sales in the U.S.; agency’s continued commitment to postmarket review of Essure and keeping women informed July 20, 2018
FDA approves first targeted treatment for patients with relapsed or refractory acute myeloid leukemia who have a certain genetic mutation July 20, 2018
Statement from FDA Commissioner Scott Gottlieb, M.D., on agency’s efforts to encourage the development of and broaden access to generic versions of opioid analgesics that are formulated to deter abuse July 20, 2018
Statement from FDA warning about significant health risks of contaminated illegal synthetic cannabinoid products that are being encountered by FDA July 19, 2018
Statement by FDA Commissioner Scott Gottlieb, M.D., on the formation of a new work group to develop focused drug importation policy options to address access challenges related to certain sole-source medicines with limited patient availability, but no blocking patents or exclusivities July 19, 2018

FDA MedWatch

Valsartan-Containing Products: Update Health Professional and Consumer on Recent Recalled Products
Fluoroquinolone Antibiotics: FDA Requires Labeling Changes Due to Low Blood Sugar Levels and Mental Health Side Effects
Kratom (mitragyna speciosa) Powder Products by Gaia Ethnobotanical: Recall - Due to Potential Salmonella Contamination
Various Aortic Endovascular Graft Systems: Letter to Health Care Providers - UPDATE on Type III Endoleaks
Compounded Products Containing Triamcinolone-Moxifloxacin by Guardian Pharmacy Services (Dallas, Texas): Alert to Health Professionals - Adverse Events Reported After Receiving Eye Injections

More Feeds

First practice guidelines for clinical evaluation of Alzheimer’s disease
Source: EurekaPublished on 2018-07-22
Women under-treated for heart attacks die at twice the rate of men
Source: EurekaPublished on 2018-07-22
First dementia prevalence data in lesbian, gay and bisexual older adults
Source: EurekaPublished on 2018-07-22
Lateral inhibition: Two modes of non-autonomous negative autoregulation by neuralized
Source: PLOS GeneticsPublished on 2018-07-21
News and press releases: Committee for Medicinal Products for Veterinary Use (CVMP) meeting of 17–19 July 2018
Source: EMA NewsPublished on 2018-07-20
SF State study compares athlete and truck driver, identical twins
Source: EurekaPublished on 2018-07-20
Parakeet pecking orders, basketball match-ups, and the tenure-track
Source: EurekaPublished on 2018-07-20
Texas A&M study: Sahara dust may make you cough, but it’s a storm killer
Source: EurekaPublished on 2018-07-20

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thasso, the new generation glocalized patient network in theragenomic and personalized medicine and individualized drug safety provides access to and sharing of personal and professional information in health and disease to individual patients, to patient subgroups, and to large patient populations worldwide

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