theragenomics: drug labels with annotated information
thasso provides the present information via PharmGKB which constantly annotates drug labels and or product monographs containing pharmacogenetic (i.e., theragenomic) information approved by the US Food and Drug Administration (FDA), the European Medicines Agency (EMA), Swiss Agency of Therapeutic Products (Swissmedic), the Pharmaceuticals and Medical Devices Agency, Japan (PMDA), and Health Canada (Santé Canada) (HCSC). PharmGKB annotations provide a brief summary of the pharmacogenetic information in the label, an excerpt from the label and a downloadable PDF file of the label in question with the respective pharmacogenetic information highlighted. A list of genes and phenotypes found within the label is mapped to label section headers and listed at the end of each annotation. PharmGKB also attempts to interpret the level of action implied in each label with the “PGx Level” tag.
Direct links to any of the informations in the below table can be found at PharmGKB Drug Label Annotations.
Drug | Biomarker | FDA | EMA | Swissmedic | PMDA | HCSC |
---|---|---|---|---|---|---|
abacavir | On | Testing required (alternative drug / prescribing info) | Testing required (alternative drug / prescribing info) | Testing required (alternative drug / prescribing info) | Informative PGx | Testing required |
abemaciclib | On | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | |||
acenocoumarol | Actionable PGx | |||||
acetaminophen | Actionable PGx (prescribing info) | Actionable PGx | ||||
acetaminophen / codeine | Testing required (alternative drug / prescribing info), Actionable PGx | |||||
acetaminophen / tramadol | Actionable PGx (prescribing info) | |||||
afatinib | On | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (cancer genome / prescribing info) | ||
afutuzumab | Off (Formerly On) | Informative PGx (cancer genome) | Informative PGx | |||
alectinib | On | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | |||
alglucosidase alfa | On | Testing required (alternative drug / prescribing info) | Testing required (alternative drug / prescribing info) | Testing required (alternative drug / prescribing info) | ||
alirocumab | Off (Formerly On) | Informative PGx | ||||
aliskiren | Informative PGx | Informative PGx | ||||
allopurinol | Actionable PGx (prescribing info) | Actionable PGx | ||||
alpelisib | On | Testing required (cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | ||
amifampridine | On | Actionable PGx (dosing info / prescribing info) | ||||
amifampridine phosphate | On | Actionable PGx (dosing info / prescribing info) | Actionable PGx, Actionable PGx | Actionable PGx | Actionable PGx (dosing info / prescribing info) | |
amitriptyline | On | Actionable PGx | ||||
amlodipine / atorvastatin / perindopril arginine | Actionable PGx | |||||
amoxapine | On | Actionable PGx | ||||
amphetamine | On | Informative PGx | ||||
anastrozole | On | Testing required (cancer genome / prescribing info) | Testing required | |||
antithrombotic agents | Actionable PGx | |||||
arformoterol | On | Informative PGx | ||||
aripiprazole | On | Actionable PGx (dosing info / prescribing info) | Actionable PGx (dosing info / prescribing info) | Actionable PGx | Actionable PGx | |
aripiprazole lauroxil | On | Actionable PGx (dosing info / alternative drug / prescribing info) | ||||
arsenic trioxide | On | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | Testing required | Testing required | |
articaine / epinephrine | On | Actionable PGx (prescribing info) | ||||
aspirin | Actionable PGx | |||||
atazanavir | Testing recommended | Actionable PGx | Informative PGx | |||
atezolizumab | On | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (cancer genome / prescribing info) | |||
atomoxetine | On | Actionable PGx (dosing info / prescribing info) | Actionable PGx | Actionable PGx | Actionable PGx | |
atorvastatin | Off (Formerly On) | Informative PGx | Informative PGx | Informative PGx | ||
avapritinib | On | Testing required (alternative drug / prescribing info) | ||||
avatrombopag | On | Actionable PGx, Informative PGx | ||||
avelumab | On | Informative PGx (cancer genome) | ||||
axitinib | Informative PGx | |||||
azathioprine | On | Testing recommended (prescribing info) | Actionable PGx (dosing info / prescribing info) | Actionable PGx | Actionable PGx | |
belimumab | Off (Formerly On) | Informative PGx | Informative PGx | Informative PGx | ||
belinostat | On | Actionable PGx (dosing info / prescribing info) | ||||
binimetinib | On | Testing required (alternative drug / cancer genome / prescribing info), Informative PGx | Testing required (alternative drug / cancer genome / prescribing info), Informative PGx | |||
bisoprolol fumarate / perindopril arginine | Actionable PGx | |||||
blinatumomab | On | Informative PGx (cancer genome) | ||||
boceprevir | On | Informative PGx | Actionable PGx | Informative PGx | ||
bosutinib | On | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | Testing required | ||
brentuximab vedotin | On | Informative PGx (cancer genome), Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | Informative PGx | ||
brexpiprazole | On | Actionable PGx (dosing info / prescribing info) | Actionable PGx (dosing info / prescribing info) | Actionable PGx (dosing info / prescribing info) | ||
brigatinib | On | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | |||
brivaracetam | On | Actionable PGx (prescribing info) | Actionable PGx | Informative PGx | Actionable PGx | |
bupropion | On | Informative PGx | ||||
busulfan | On | Actionable PGx (cancer genome / prescribing info) | ||||
cabazitaxel | Informative PGx | |||||
cabozantinib | On | Informative PGx | ||||
capecitabine | On | Actionable PGx (prescribing info) | Testing recommended (alternative drug / prescribing info) | Actionable PGx (dosing info / alternative drug / prescribing info) | Actionable PGx | Actionable PGx |
capmatinib | On | Testing required (alternative drug / cancer genome / prescribing info) | ||||
carbamazepine | On | Testing required (alternative drug / prescribing info), Actionable PGx | Testing required (alternative drug / prescribing info), Testing recommended (alternative drug / prescribing info) | Actionable PGx | Testing recommended | |
carbasalate calcium | Actionable PGx | |||||
carglumic acid | On | Testing required (alternative drug / prescribing info) | Testing required (alternative drug / prescribing info) | Testing required | ||
cariprazine | On | Informative PGx | ||||
carisoprodol | On | Actionable PGx (prescribing info) | ||||
carvedilol | On | Actionable PGx | Informative PGx | Actionable PGx | ||
ceftriaxone | On | Actionable PGx (prescribing info) | ||||
celecoxib | On | Actionable PGx (dosing info / prescribing info) | Actionable PGx | Actionable PGx | Actionable PGx | |
ceritinib | On | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | Testing required | ||
cerliponase alfa | On | Testing required (alternative drug / prescribing info) | Testing required (alternative drug / prescribing info) | |||
cetuximab | On | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | Testing required | Testing required | |
cevimeline | On | Actionable PGx (prescribing info) | ||||
chloroprocaine | On | Actionable PGx | ||||
chloroquine | On | Actionable PGx (prescribing info) | Actionable PGx (alternative drug / prescribing info) | |||
chlorpropamide | On | Actionable PGx (prescribing info) | Actionable PGx | |||
cholic acid | Off (Formerly On) | Testing required (alternative drug / prescribing info) | Testing required (alternative drug / prescribing info) | |||
ciprofloxacin | Actionable PGx | |||||
cisplatin | On | Informative PGx | ||||
citalopram | On | Actionable PGx (dosing info / prescribing info), Informative PGx | Actionable PGx (dosing info / prescribing info) | Actionable PGx | ||
clobazam | On | Actionable PGx (dosing info / prescribing info) | ||||
clomipramine | On | Actionable PGx | Actionable PGx | |||
clopidogrel | On | Actionable PGx (prescribing info) | Actionable PGx | Actionable PGx (dosing info / prescribing info) | Actionable PGx | Actionable PGx |
clozapine | On | Actionable PGx (prescribing info) | ||||
cobimetinib | On | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | |||
codeine | On | Actionable PGx (alternative drug / prescribing info) | Actionable PGx (alternative drug / prescribing info) | Actionable PGx | Actionable PGx | |
crizanlizumab-tmca | On | Informative PGx | ||||
crizotinib | On | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | Testing required | Testing required | |
dabrafenib | On | Testing required (alternative drug / cancer genome / prescribing info), Actionable PGx, Informative PGx | Testing required (alternative drug / cancer genome / prescribing info) | Testing required | ||
daclatasvir | On | Informative PGx | Informative PGx | |||
dacomitinib | On | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | |||
dapoxetine | Actionable PGx (dosing info / prescribing info) | |||||
dapsone | On | Actionable PGx | Actionable PGx | Actionable PGx | ||
darifenacin | On | Actionable PGx | Actionable PGx | Actionable PGx | Actionable PGx | |
darunavir | Informative PGx | |||||
dasabuvir | Actionable PGx | |||||
dasabuvir / ombitasvir / paritaprevir / ritonavir | On | Informative PGx | ||||
dasatinib | On | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | Testing required | Testing required | |
denileukin diftitox | On | Testing required (alternative drug / cancer genome / prescribing info) | ||||
desflurane | On | Actionable PGx (alternative drug / prescribing info) | Actionable PGx | |||
desipramine | On | Actionable PGx | ||||
desloratadine | Informative PGx | |||||
desvenlafaxine | On | Informative PGx | ||||
deutetrabenazine | On | Actionable PGx (dosing info / prescribing info) | ||||
dexlansoprazole | On | Actionable PGx | Actionable PGx | Actionable PGx | ||
dextromethorphan | Actionable PGx | |||||
dextromethorphan / quinidine | On | Testing recommended | Actionable PGx (prescribing info) | |||
diazepam | On | Actionable PGx | ||||
dinutuximab | On | Informative PGx (cancer genome) | ||||
divalproex sodium | Off (Formerly On) | Testing required (alternative drug / prescribing info) | Testing required | |||
docetaxel | On | Informative PGx (cancer genome) | ||||
dolutegravir | On | Actionable PGx | Actionable PGx | Informative PGx | ||
dolutegravir / abacavir / lamivudine | Testing required (prescribing info) | |||||
donepezil | On | Actionable PGx | ||||
dotatate lutenium lu-177 | On | Testing required (alternative drug / cancer genome / prescribing info) | ||||
doxepin | On | Actionable PGx | ||||
dronabinol | On | Actionable PGx (prescribing info) | ||||
dronedarone | Informative PGx | |||||
drospirenone / ethinyl estradiol | On | Informative PGx | Actionable PGx | |||
duloxetine | On | Actionable PGx | Actionable PGx | Actionable PGx | ||
durvalumab | On | Informative PGx (cancer genome) | ||||
duvelisib | On | Informative PGx (cancer genome) | ||||
eculizumab | On | Testing required (alternative drug / prescribing info) | ||||
efavirenz | On | Actionable PGx | Actionable PGx | Actionable PGx | Actionable PGx | |
efavirenz / emtricitabine / tenofovir disoproxil | Actionable PGx | Actionable PGx | ||||
elagolix | On | Actionable PGx | ||||
elbasvir / grazoprevir | On | Informative PGx | ||||
eletriptan | Informative PGx | |||||
elexacaftor / tezacaftor / ivacaftor | On | Testing required (alternative drug / prescribing info) | ||||
eliglustat | On | Testing required (dosing info / prescribing info) | Testing required (dosing info / alternative drug / prescribing info) | Testing required | ||
elosulfase alfa | On | Testing required (alternative drug / prescribing info) | Testing required (alternative drug / prescribing info) | |||
eltrombopag | On | Actionable PGx | Actionable PGx (prescribing info) | Actionable PGx | Actionable PGx | |
emapalumab | On | Informative PGx | ||||
enasidenib | On | Testing required (alternative drug / cancer genome / prescribing info) | ||||
encorafenib | On | Testing required (alternative drug / cancer genome / prescribing info), Actionable PGx (cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | |||
enflurane | Off (Formerly On) | Actionable PGx (alternative drug / prescribing info) | ||||
enfortumab vedotin | On | Informative PGx | ||||
entrectinib | On | Testing required (alternative drug / cancer genome / prescribing info) | ||||
erdafitinib | On | Testing required (alternative drug / cancer genome / prescribing info), Actionable PGx (prescribing info) | ||||
eribulin | On | Informative PGx (cancer genome) | ||||
erlotinib | On | Testing required (alternative drug / cancer genome / prescribing info) | Actionable PGx, Testing required (alternative drug / cancer genome / prescribing info) | Testing required | Testing required | |
erythromycin ethylsuccinate / sulfisoxazole acetyl | On | Actionable PGx | Actionable PGx | |||
escitalopram | On | Actionable PGx, Informative PGx | Informative PGx, Actionable PGx (dosing info / prescribing info) | Actionable PGx | ||
esomeprazole | On | Actionable PGx | Informative PGx (prescribing info) | Informative PGx | ||
estradiol / progesterone | On | Actionable PGx (prescribing info) | ||||
eteplirsen | On | Testing required (alternative drug / prescribing info) | ||||
ethinyl estradiol / norelgestromin | Actionable PGx (alternative drug / prescribing info) | Actionable PGx | ||||
everolimus | On | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | Testing required | Testing required | |
evolocumab | Off (Formerly On) | Informative PGx | ||||
exemestane | On | Testing required (alternative drug / cancer genome / prescribing info) | Testing required | |||
ezetimibe / rosuvastatin | Actionable PGx (prescribing info) | |||||
ezetimibe / simvastatin | Testing recommended (dosing info / prescribing info) | |||||
fampridine | Informative PGx | |||||
fam-trastuzumab deruxtecan-nxki | On | Testing required (alternative drug / cancer genome / prescribing info) | ||||
fenofibrate | Actionable PGx | |||||
fesoterodine | On | Actionable PGx | Actionable PGx | Actionable PGx | Actionable PGx | Actionable PGx |
flibanserin | On | Actionable PGx | ||||
flucloxacillin | Actionable PGx | |||||
flucytosine | Testing recommended | |||||
fluorouracil | On | Actionable PGx (alternative drug / prescribing info) | Testing required, Actionable PGx | Actionable PGx | Actionable PGx | |
fluorouracil / salicylic acid | Testing recommended | |||||
fluoxetine | On | Informative PGx | Informative PGx | |||
fluoxetine / olanzapine | Off (Never On) | Actionable PGx | ||||
flurbiprofen | On | Actionable PGx (dosing info / prescribing info) | ||||
flutamide | On | Actionable PGx | ||||
fluvoxamine | On | Actionable PGx | Actionable PGx | |||
formoterol | On | Informative PGx | ||||
fosamprenavir | Informative PGx | |||||
fosphenytoin | On | Actionable PGx (prescribing info) | ||||
fulvestrant | On | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | Testing required | ||
galantamine | On | Informative PGx (prescribing info) | Actionable PGx | Informative PGx | ||
gefitinib | On | Testing required (alternative drug / cancer genome / prescribing info), Actionable PGx (prescribing info) | Testing required (alternative drug / cancer genome / prescribing info), Actionable PGx (prescribing info) | Actionable PGx | Testing required | Testing required |
gemtuzumab ozogamicin | On | Testing required (alternative drug / cancer genome / prescribing info) | ||||
gilteritinib | On | Testing required (alternative drug / cancer genome / prescribing info) | ||||
givosiran | On | Informative PGx | ||||
glibenclamide | Off (Formerly On) | Actionable PGx (prescribing info) | Actionable PGx (alternative drug / prescribing info) | Actionable PGx | Actionable PGx | |
gliclazide | Actionable PGx | |||||
glimepiride | On | Actionable PGx (prescribing info) | Actionable PGx (prescribing info) | Actionable PGx | Actionable PGx | |
glipizide | On | Actionable PGx (prescribing info) | ||||
golodirsen | On | Testing required (alternative drug / prescribing info) | ||||
goserelin | On | Informative PGx | ||||
haloperidol | Actionable PGx | |||||
homoharringtonine | Off (Formerly On) | Informative PGx (cancer genome) | ||||
hydralazine / isosorbide dinitrate | On | Informative PGx | ||||
hydroxychloroquine | On | Actionable PGx (prescribing info) | Actionable PGx | |||
ibritumomab | Off (Formerly On) | Informative PGx (cancer genome) | Informative PGx | |||
ibrutinib | On | Testing required (alternative drug / cancer genome / prescribing info), Informative PGx (cancer genome) | Testing required (cancer genome / prescribing info) | Informative PGx | Testing required | |
iloperidone | On | Actionable PGx (dosing info / prescribing info) | ||||
imatinib | On | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | Testing required | Testing required | |
imipramine | On | Actionable PGx | ||||
indacaterol | On | Informative PGx | Informative PGx | Informative PGx | Actionable PGx | |
indinavir | Informative PGx | |||||
inebilizumab-cdon | On | Testing required (alternative drug / prescribing info) | ||||
inotersen | On | Informative PGx | ||||
inotuzumab ozogamicin | On | Informative PGx (cancer genome) | ||||
ipilimumab | On | Informative PGx, Testing required (alternative drug / cancer genome / prescribing info) | ||||
irinotecan | On | Actionable PGx (dosing info / prescribing info) | Actionable PGx (prescribing info) | Actionable PGx (dosing info / prescribing info) | Testing recommended | Actionable PGx |
isatuximab-irfc | On | Informative PGx (cancer genome) | ||||
isoflurane | On | Actionable PGx (alternative drug / prescribing info) | Actionable PGx | |||
isoniazid | Informative PGx | |||||
isoniazid / pyrazinamide / rifampin | On | Informative PGx | ||||
isosorbide dinitrate | On | Informative PGx | ||||
isosorbide mononitrate | On | Informative PGx | ||||
ivabradine | Informative PGx | |||||
ivacaftor | On | Testing required (alternative drug / prescribing info) | Testing required (alternative drug / prescribing info) | Testing required | ||
ivacaftor / lumacaftor | On | Testing required (alternative drug / prescribing info) | Testing required (alternative drug / prescribing info) | |||
ivacaftor / tezacaftor | On | Testing required (alternative drug / prescribing info) | Testing required (alternative drug / prescribing info) | |||
ivosidenib | On | Testing required (alternative drug / cancer genome / prescribing info) | ||||
ixabepilone | On | Informative PGx (cancer genome) | ||||
lacosamide | On | Informative PGx | Informative PGx | |||
lamivudine / abacavir | Testing required (prescribing info) | |||||
lansoprazole | On | Informative PGx | Actionable PGx | |||
lapatinib | On | Testing required (alternative drug / cancer genome / prescribing info), Actionable PGx | Actionable PGx, Testing required (alternative drug / cancer genome / prescribing info) | Actionable PGx | Testing required | Testing required |
larotrectinib sulfate | On | Testing required (alternative drug / cancer genome / prescribing info) | ||||
ledipasvir / sofosbuvir | On | Informative PGx | ||||
lenalidomide | On | Testing required | Informative PGx | Informative PGx | Informative PGx | |
lenvatinib | On | Testing required (alternative drug / cancer genome / prescribing info) | ||||
lesinurad | On | Actionable PGx (prescribing info) | Actionable PGx (prescribing info) | Informative PGx | ||
letermovir | Informative PGx | |||||
letrozole | On | Testing required (alternative drug / cancer genome / prescribing info) | Actionable PGx | Testing required | ||
lidocaine and tetracaine | On | Actionable PGx (prescribing info) | ||||
lidocaine / prilocaine | On | Actionable PGx | Actionable PGx | |||
lofexidine | On | Actionable PGx (prescribing info) | ||||
lomitapide | Off (Formerly On) | Informative PGx | Testing required | Informative PGx | ||
lorlatinib | On | Testing required (alternative drug / cancer genome / prescribing info), Informative PGx (cancer genome) | Testing required (alternative drug / cancer genome / prescribing info) | |||
losartan | Actionable PGx | |||||
luspatercept-aamt | On | Informative PGx | ||||
lusutrombopag | On | Actionable PGx | ||||
mafenide | On | Actionable PGx | ||||
maraviroc | Off (Formerly On) | Informative PGx | Actionable PGx | |||
meclizine | On | Actionable PGx (prescribing info) | ||||
mefloquine | Informative PGx | |||||
meloxicam | On | Actionable PGx (prescribing info) | ||||
mepivacaine | On | Actionable PGx (prescribing info) | ||||
mercaptopurine | On | Testing recommended (dosing info / prescribing info) | Actionable PGx (prescribing info) | Actionable PGx (prescribing info) | Actionable PGx | |
metabutethamine | Actionable PGx (prescribing info) | |||||
methylene blue | On | Actionable PGx (alternative drug / prescribing info) | Actionable PGx (alternative drug / prescribing info) | Actionable PGx | ||
metoclopramide | On | Actionable PGx, Actionable PGx (dosing info / prescribing info) | ||||
metoprolol | On | Informative PGx | Actionable PGx | Actionable PGx | ||
midostaurin | On | Informative PGx, Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | |||
migalastat | On | Testing required (alternative drug / prescribing info) | Testing required (alternative drug / prescribing info) | |||
mipomersen | Off (Formerly On) | Informative PGx | ||||
mirabegron | On | Actionable PGx | Informative PGx (prescribing info) | Informative PGx | ||
mivacurium chloride | On | Actionable PGx (prescribing info) | Actionable PGx | |||
moclobemide | Actionable PGx | |||||
modafinil | On | Actionable PGx | ||||
moviprep | Off (Formerly On) | Actionable PGx (prescribing info) | Actionable PGx | Actionable PGx | ||
moxifloxacin | Actionable PGx (prescribing info) | |||||
mycophenolic acid | On | Actionable PGx (alternative drug / prescribing info) | Actionable PGx | Actionable PGx | ||
nalidixic acid | On | Actionable PGx (prescribing info) | Actionable PGx | |||
nebivolol | On | Informative PGx (prescribing info) | Informative PGx | |||
nefazodone | On | Informative PGx (prescribing info) | ||||
nelfinavir | Off (Formerly On) | Informative PGx | Informative PGx | |||
neratinib | On | Informative PGx, Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | |||
nicorandil | Actionable PGx (prescribing info) | |||||
nilotinib | On | Testing required (alternative drug / cancer genome / prescribing info), Actionable PGx | Testing required (alternative drug / cancer genome / prescribing info) | Actionable PGx, Testing required | ||
niraparib | On | Testing required (alternative drug / cancer genome / prescribing info) | ||||
nitrofurantoin | On | Actionable PGx | Actionable PGx (alternative drug / prescribing info) | Actionable PGx | ||
nitroglycerin | Actionable PGx | |||||
nivolumab | On | Informative PGx (cancer genome), Testing required (alternative drug / cancer genome / prescribing info) | ||||
norfloxacin | Off (Never On) | Actionable PGx | Actionable PGx | Actionable PGx | ||
nortriptyline | On | Actionable PGx | Actionable PGx | |||
nusinersen | On | Informative PGx | ||||
ofatumumab | Off (Formerly On) | Informative PGx (cancer genome) | Informative PGx | |||
ofloxacin | Actionable PGx (prescribing info) | |||||
olanzapine | Informative PGx | |||||
olaparib | On | Informative PGx (cancer genome), Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | |||
olaratumab | On | Informative PGx (cancer genome) | ||||
oliceridine | Off (Never On) | Actionable PGx (prescribing info) | ||||
ombitasvir / paritaprevir / ritonavir | On | Informative PGx | Actionable PGx | |||
omeprazole | On | Actionable PGx | Actionable PGx | Informative PGx | Informative PGx | |
ondansetron | On | Informative PGx | Informative PGx | |||
Opium derivatives and expectorants | Actionable PGx | |||||
osimertinib | On | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | |||
ospemifene | On | Informative PGx | ||||
oxcarbazepine | On | Testing recommended (alternative drug / prescribing info) | Testing required (alternative drug / prescribing info) | Testing recommended (alternative drug / prescribing info) | ||
oxycodone | Actionable PGx | |||||
oxymetazoline and tetracaine | On | Actionable PGx (prescribing info) | ||||
palbociclib | On | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | |||
paliperidone | On | Informative PGx | Informative PGx | |||
palonosetron | On | Informative PGx | Informative PGx | Informative PGx | ||
panitumumab | On | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | Testing required | Testing required | |
pantoprazole | On | Actionable PGx (prescribing info) | Informative PGx | |||
Paracetamol, combinations excl. Psycholeptics (Vicks MediNait Sirup) | Actionable PGx (prescribing info) | |||||
Parathyroid Hormones And Analogues | On | Informative PGx | ||||
paroxetine | On | Informative PGx | ||||
pazopanib | On | Actionable PGx | Actionable PGx | Actionable PGx | ||
peginterferon alfa-2b | On | Actionable PGx | ||||
pegloticase | On | Testing required (alternative drug / prescribing info) | Testing required | |||
pembrolizumab | On | Testing required (alternative drug / cancer genome / prescribing info), Informative PGx (cancer genome) | Testing required (alternative drug / cancer genome / prescribing info) | |||
perindopril | Actionable PGx | |||||
perphenazine | On | Actionable PGx | Actionable PGx | |||
pertuzumab | On | Testing required (alternative drug / cancer genome / prescribing info), Actionable PGx (cancer genome) | Testing required (alternative drug / cancer genome / prescribing info) | Testing required | ||
phenytoin | On | Actionable PGx (prescribing info) | Actionable PGx (dosing info / prescribing info) | Testing recommended | ||
pimozide | On | Testing required (dosing info / prescribing info) | ||||
pioglitazone | Actionable PGx (prescribing info) | |||||
piroxicam | On | Actionable PGx (prescribing info) | Actionable PGx | |||
pitavastatin | Actionable PGx | |||||
pitolisant | On | Actionable PGx (dosing info / prescribing info) | ||||
ponatinib | On | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | Testing required | ||
posaconazole | Informative PGx | |||||
prasugrel | On | Informative PGx | Informative PGx | Informative PGx | ||
pravastatin | Off (Formerly On) | Informative PGx, Informative PGx | ||||
prilocaine | Actionable PGx | |||||
primaquine | On | Testing required (alternative drug / prescribing info), Actionable PGx | Actionable PGx | |||
probenecid | On | Actionable PGx | ||||
procainamide | On | Informative PGx (prescribing info) | ||||
propafenone | On | Actionable PGx (prescribing info) | Actionable PGx | Actionable PGx | ||
propranolol | On | Informative PGx | Informative PGx | |||
protriptyline | On | Actionable PGx | ||||
quinidine | On | Informative PGx | ||||
quinine | On | Actionable PGx (prescribing info) | Actionable PGx (alternative drug / prescribing info) | Actionable PGx | ||
rabeprazole | On | Actionable PGx | Actionable PGx | Actionable PGx | Actionable PGx | |
raloxifene | On | Informative PGx | ||||
raltegravir | On | Informative PGx | Informative PGx (prescribing info) | |||
ramucirumab | On | Informative PGx (cancer genome), Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info), Informative PGx (cancer genome) | |||
ranolazine | Actionable PGx | Actionable PGx (prescribing info) | ||||
rasburicase | On | Informative PGx, Testing required (alternative drug / prescribing info) | Actionable PGx (alternative drug / prescribing info) | Actionable PGx (alternative drug / prescribing info) | Actionable PGx | Testing recommended |
regorafenib | On | Informative PGx (cancer genome) | Actionable PGx (cancer genome) | |||
ribociclib | On | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | |||
rimegepant | On | Informative PGx | ||||
risperidone | On | Informative PGx (prescribing info) | Informative PGx | Informative PGx | ||
ritonavir | Informative PGx | |||||
rituximab | On | Informative PGx (cancer genome) | Testing required | |||
rivaroxaban | On | Informative PGx | ||||
ropivacaine | On | Actionable PGx | ||||
rosuvastatin | On | Actionable PGx | Actionable PGx (prescribing info) | Actionable PGx | ||
rucaparib | On | Informative PGx, Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info), Informative PGx | |||
ruxolitinib | Informative PGx | |||||
sacituzumab govitecan-hziy | On | Actionable PGx (prescribing info) | ||||
selpercatinib | On | Testing required (alternative drug / cancer genome / prescribing info) | ||||
sertindole | Actionable PGx | |||||
sevoflurane | On | Actionable PGx (alternative drug / prescribing info) | Actionable PGx | |||
sildenafil | Informative PGx | |||||
simeprevir | On | Informative PGx | Informative PGx | |||
simvastatin | Actionable PGx, Testing recommended (prescribing info) | |||||
siponimod | On | Testing required (dosing info / alternative drug / prescribing info) | ||||
sirolimus | Informative PGx | |||||
sodium benzoate / sodium phenylacetate | Off (Formerly On) | Testing required | ||||
sodium nitrite | On | Actionable PGx (prescribing info) | Actionable PGx | |||
sodium phenylbutyrate | On | Testing required | Informative PGx (alternative drug / prescribing info) | Testing required | ||
sofosbuvir | On | Informative PGx | Actionable PGx (prescribing info) | |||
sofosbuvir / velpatasvir | On | Informative PGx | ||||
sofosbuvir / velpatasvir / voxilaprevir | On | Informative PGx | ||||
succimer | On | Informative PGx | ||||
succinylcholine | On | Actionable PGx (alternative drug / prescribing info) | Actionable PGx | |||
sulfadiazine | On | Actionable PGx | Actionable PGx | Actionable PGx | Actionable PGx | |
sulfamethoxazole / trimethoprim | On | Actionable PGx | Actionable PGx | Actionable PGx | Actionable PGx | |
sulfasalazine | On | Actionable PGx (prescribing info) | Actionable PGx | Actionable PGx | Actionable PGx | |
sunitinib | Informative PGx | |||||
tafamidis | On | Informative PGx | ||||
tafenoquine | On | Testing required (alternative drug / prescribing info) | ||||
talazoparib | On | Testing required (alternative drug / prescribing info), Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | |||
tamoxifen | On | Testing required (alternative drug / cancer genome / prescribing info), Actionable PGx, Informative PGx | Actionable PGx | Testing required | ||
tamsulosin | On | Actionable PGx (prescribing info) | Actionable PGx | |||
telaprevir | On | Actionable PGx | Actionable PGx | |||
telithromycin | Informative PGx | |||||
terbinafine | Off (Formerly On) | Informative PGx | ||||
tetrabenazine | On | Testing required (dosing info / prescribing info) | Testing required (prescribing info) | Actionable PGx | Actionable PGx | |
thioguanine | On | Testing recommended (dosing info / prescribing info) | Actionable PGx (dosing info / prescribing info) | Actionable PGx | ||
thioridazine | On | Actionable PGx (alternative drug / prescribing info) | ||||
ticagrelor | On | Informative PGx | Actionable PGx | |||
timolol | Informative PGx | |||||
tiotropium | Off (Formerly On) | Informative PGx | ||||
tipiracil / trifluridine | On | Testing required (cancer genome / prescribing info) | ||||
tipranavir | Informative PGx | |||||
tolazamide | On | Actionable PGx (prescribing info) | ||||
tolbutamide | On | Actionable PGx (prescribing info) | Actionable PGx | |||
tolperisone | Actionable PGx | |||||
tolterodine | On | Actionable PGx | Actionable PGx | Informative PGx | Informative PGx | |
toremifene | On | Testing required (cancer genome / prescribing info) | Actionable PGx (cancer genome / prescribing info) | |||
tositumomab | Off (Formerly On) | Informative PGx (cancer genome) | ||||
tramadol | On | Actionable PGx (alternative drug / prescribing info) | Actionable PGx | |||
trametinib | On | Testing required (alternative drug / cancer genome / prescribing info), Informative PGx, Informative PGx (cancer genome) | Testing required (alternative drug / cancer genome / prescribing info) | Testing required | ||
trastuzumab | On | Actionable PGx (cancer genome), Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | Testing required | Testing required | |
trastuzumab emtansine | On | Testing required (alternative drug / cancer genome / prescribing info) | Testing required (alternative drug / cancer genome / prescribing info) | Testing required | ||
tretinoin | On | Testing required (alternative drug / cancer genome / prescribing info) | Informative PGx | Testing required | ||
trimipramine | On | Actionable PGx | ||||
tucatinib | On | Testing required (alternative drug / cancer genome / prescribing info) | ||||
umeclidinium | On | Informative PGx | Informative PGx | Informative PGx | ||
umeclidinium / vilanterol | Informative PGx | |||||
upadacitinib | On | Informative PGx | ||||
ustekinumab | On | Informative PGx | ||||
valbenazine | On | Actionable PGx (prescribing info) | ||||
valproic acid | On | Actionable PGx (alternative drug / prescribing info), Testing required (alternative drug / prescribing info) | Actionable PGx | Actionable PGx | ||
vandetanib | Testing recommended (cancer genome), Testing recommended | |||||
vardenafil | Informative PGx | |||||
velaglucerase alfa | Off (Formerly On) | Testing required (alternative drug / prescribing info) | Testing required (alternative drug / prescribing info) | Testing required | ||
vemurafenib | On | Testing required (alternative drug / cancer genome / prescribing info), Informative PGx (cancer genome) | Testing required (alternative drug / cancer genome / prescribing info) | Testing required | Testing required | |
venetoclax | On | Informative PGx (cancer genome) | ||||
venlafaxine | On | Actionable PGx | Actionable PGx | |||
vernakalant | Informative PGx | |||||
vincristine | On | Testing required (alternative drug / cancer genome / prescribing info) | ||||
Vitamin B-complex with vitamin C | Actionable PGx | |||||
vitamin c | Actionable PGx (dosing info / prescribing info) | |||||
voriconazole | On | Actionable PGx | Informative PGx | Actionable PGx | Actionable PGx | Actionable PGx |
vortioxetine | On | Actionable PGx (dosing info / prescribing info) | Actionable PGx (dosing info / prescribing info) | Actionable PGx | Actionable PGx | |
voxelotor | On | Informative PGx | ||||
warfarin | On | Actionable PGx (prescribing info) | Actionable PGx | |||
zidovudine / lamivudine / abacavir | Testing required (prescribing info) | |||||
zonisamide | Informative PGx | |||||
zuclopenthixol | Informative PGx |
Legend (how to read);
- Genetic testing required: The label states or implies that some sort of gene, protein or chromosomal testing, including genetic testing, functional protein assays, cytogenetic studies, etc., should be conducted before using this drug.
- Genetic testing recommended: The label states or implies that some sort of gene, protein or chromosomal testing, including genetic testing, functional protein assays, cytogenetic studies, etc., is recommended before using this drug.
- Actionable PGx: The label does not discuss genetic or other testing for gene/protein/chromosomal variants, but does contain information about changes in efficacy, dosage or toxicity due to such variants.
- Informative PGx: The label mentions a gene or protein is involved in the metabolism or pharmacodynamics of the drug, but there is no information to suggest that variation in these genes/proteins leads to different response.