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Are Asians at higher genetic risk of serious adverse events to common medications?

March 10, 2020 – A widespread assumption is, the people of Asian descent are more prone to serious, sometimes deadly adverse drug reactions, even when taking rather common medications prescribed for gout through to depression. In the ages of genetics and precision medicine, the question then comes up if Asian people could be at such heightened risk because of underlying particular genetic factors.

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The diversity of Asian genomes

January 26, 2020 – An effort to map thousends of genomes across Asia has certainly the potential to find novel gene variants affecting disease and responses to drugs, and to reveal the complex origins of Asian populations.

In a pilot study,

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East Asians, Europeans: Genomic Features of Lung Adenocarcinoma Differ

February 05, 2020 – Lung adenocarcinoma is a common cancer and leads to more than one million deaths each year, Lung tumors isolated from adenocarcinoma patients of East Asian ancestry have a less complex genomic architecture than tumors from European patients, a new study has found.

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Degree of African ancestry may influence gene expression levels

January 26, 2020 – Common belief holds that differences in genes (i.e., allelic variants) in combination with differing frequencies of such allelic variants in populations of different ethnic background may explain the differences in the frequency and/or severity of overt diseases in different ethnic groups and/or populations.

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In Caribbeans cystic fibrosis (CF) is driven by very rare CFTR mutations

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Hidden secrets in African genomes revealed by large scale sequencing

October 20, 2019 – Sequencing African genomes yields new data resource with broad applicability. By collaborating globally in a new, large-scale effort, researchers have made strong progress in sequencing genomes from regions and countries across Africa. These findings will enable more broadly representative and relevant studies ranging from basic through clinical genetics.

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Black people with natural blonde hair – Everything is possible in genetics

August 07, 2019 – Blonde hair is a rare human phenotype found almost exclusively in Europe and Oceania. Human pigmentation varies considerably within and among populations and is a function of both variation in exposure to ultraviolet radiation (UVR) and the type and quantity of melanin produced in melanocytes and keratinocytes.

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ZRANB3 in African Populations: New Type 2 Diabetes risk locus identified

August 03, 2019 – Africa is considered the original cradle of all humanity, to which all humans can trace their genetic origin. This may be very interesting in the context of diseases that are due to genetic predispositions both in todays African populations and in all the populations descendant of African origin worldwide.

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Risk loci for post-traumatic stress disorder (PTSD)

August 01, 2019 – Post-Traumatic Stress Disorder (PTSD) is a mental disorder that can develop after a person is exposed to a traumatic event, such as sexual assault, warfare, traffic collisions, or other threats on a person’s life. Symptoms may include disturbing thoughts,

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Ethnic disparities in the occurrence of prostate cancer

May 10, 2018 – A seemingly higher incidence of prostate cancer and resulting fatalities in African-American men than in European-Amcerican men has been noted for quite some time. New research published in Molecular Oncology may help explain why African American men are at a higher risk of being diagnosed with prostate cancer and a higher risk of dying from the disease compared with European American men.

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  • Study identifies pitfall for correcting mutations in human embryos with CRISPR October 29, 2020
    In a paper published today in the journal Cell, scientists describe unexpected, undesirable outcomes after editing genes in human embryos with CRISPR, a genomic editing system.
  • Spread of a novel SARS-CoV-2 variant across Europe in summer 2020 October 29, 2020
    Researchers from Basel and Spain have identified a novel SARS-CoV-2 variant that has spread widely across Europe in recent months, according to an un-peer-reviewed preprint released this week. While there is no evidence of this variant being more dangerous, its spread may give insights into the efficacy of travel policies adopted by European countries during […]
  • New 'epigenetic' clock provides insight into how the human brain ages October 29, 2020
    While our circadian body clock dictates our preferred rhythm of sleep or wakefulness, a relatively new concept—the epigenetic clock—could inform us about how swiftly we age, and how prone we are to diseases of old age.
  • Results of COVID-19 host genetics initiative study announced at ASHG 2020 October 29, 2020
    The COVID-19 pandemic is a global health crisis. Insights into why some people develop more severe symptoms than others and how to better treat the disease are desperately needed. The COVID-19 Host Genetics Initiative was created to study the relationship between variation in the human genome and SARS-CoV-2 infection. This is an ongoing, international, collaborative […]
  • Genetics and the COVID-19 pandemic October 29, 2020
    With the COVID-19 pandemic still raging worldwide, members of the American Society of Human Genetics (ASHG) are working to understand how the virus spreads and infects people, why there is so much variability in susceptibility and severity, and where to look for potential therapeutics. Researchers presented the results of several studies relevant to the current […]
  • Why people with dementia go missing October 29, 2020
    People with dementia are more likely to go missing in areas where road networks are dense, complicated and disordered - according to new research from the University of East Anglia. Researchers studied hundreds of 'missing person' police reports for people with dementia and compared each case to the surrounding road network.They hope their findings could […]
  • An Earth-sized rogue planet discovered in the Milky Way October 29, 2020
    Our Galaxy may be teeming with rogue planets, gravitationally unbound to any star. An international team of scientists, led by Polish astronomers, has announced the discovery of the smallest Earth-sized free-floating planet found to date.
  • Curbing COVID-19 hospitalizations requires attention to construction workers October 29, 2020
    Construction workers, who are disproportionately Hispanic or Latino, have a much higher risk of becoming hospitalized with the novel coronavirus than non-construction workers, according to a new study in JAMA Network Open.
  • Some COVID-19 "long haulers" experience lasting skin problems October 29, 2020
    Some patients with COVID-19 have persistent skin-related symptoms long after their initial infection has cleared, according to a new analysis. The findings, presented at the 29th Congress of the European Academy of Dermatology and Venereology by investigators at Massachusetts General Hospital, point to another burden experienced by so-called "long haulers" who get better but don't […]
  • Early results from DETECT study suggest fitness trackers can predict COVID-19 infections October 29, 2020
    Examining data from the first six weeks of their landmark DETECT study, a team of scientists from the Scripps Research Translational Institute sees encouraging signs that wearable fitness devices can improve public health efforts to control COVID-19.
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