the glocalized network in theragenomic and personalized medicine and the genetics of individual patients safety of drugs
March 01, 2023 – The gene APOE codes for apolipoprotein E (Apo-E), a protein involved in the metabolism of fats in the body of mammals. A subtype is implicated in the Alzheimer’s disease and cardiovascular diseases. Recently, researchers at Stanford University …
APOE Missense Variant Linked to Increased Alzheimer’s Disease Risk in African Americans Read more »
November 27, 2022 – About 3.5–5.9% of the world population are affected by a rare diseases. For Africa alone, this winds up to around 50 million possibly affected people, representing a large community of individuals and families in need of diagnostics …
Including Africa in the research on rare genetic diseases: A must! Read more »
September 25, 2022 – Nearly 2000 years ago the Roman scholar and natural philosopher Pliny the Elder wrote in his Natural History: “Ex Africa surgit semper aliquid novi” (from Africa there is always something new). This quote beautifully applies to …
September 21, 2022 – Here, a big bias in genetic research into its applicability on “personalized”, or “precision”, or “theragenomic” medicine is finally addressed and brought forward to all involved in these fields. The problem until now is (and was} that …
March 10, 2022 – In a new report distributed in “Circulation: Genomic and Precision”, scientists showed that as while numerous African Americans, particularly those with a high African Family extent, have a good lipid profile, they are at a higher …
July 14, 2021 – Why does a SARS-CoV-2 infection make some people so sick with Covid-19 disease? And why do some infected people barely fall ill if at all? The answer may be that you have to talk to their …
Genetic susceptibility and severity loci for Covid-19 disease Read more »
March 10, 2020 – A widespread assumption is, the people of Asian descent are more prone to serious, sometimes deadly adverse drug reactions, even when taking rather common medications prescribed for gout through to depression. In the ages of genetics …
Are Asians at higher genetic risk of serious adverse events to common medications? Read more »
February 05, 2020 – Lung adenocarcinoma is a common cancer and leads to more than one million deaths each year, Lung tumors isolated from adenocarcinoma patients of East Asian ancestry have a less complex genomic architecture than tumors from European …
East Asians, Europeans: Genomic Features of Lung Adenocarcinoma Differ Read more »
January 26, 2020 – An effort to map thousends of genomes across Asia has certainly the potential to find novel gene variants affecting disease and responses to drugs, and to reveal the complex origins of Asian populations. In a pilot …
January 26, 2020 – Common belief holds that differences in genes (i.e., allelic variants) in combination with differing frequencies of such allelic variants in populations of different ethnic background may explain the differences in the frequency and/or severity of overt …
Degree of African ancestry may influence gene expression levels Read more »