Blog Archives

Risk loci for post-traumatic stress disorder (PTSD)

August 01, 2019 – Post-Traumatic Stress Disorder (PTSD) is a mental disorder that can develop after a person is exposed to a traumatic event, such as sexual assault, warfare, traffic collisions, or other threats on a person’s life. Symptoms may include disturbing thoughts,

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Ethnic disparities in the occurrence of prostate cancer

May 10, 2018 – A seemingly higher incidence of prostate cancer and resulting fatalities in African-American men than in European-Amcerican men has been noted for quite some time. New research published in Molecular Oncology may help explain why African American men are at a higher risk of being diagnosed with prostate cancer and a higher risk of dying from the disease compared with European American men.

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Gene expression and ethnicity: Does it matter?

December 05, 2017 – We are entering the age of precision medicine, in which diagnosis and therapy decisions for each patient will be based on detailed genetic and molecular fingerprints. Unfortunately, much of the revolutionary work that underpins precision medicine has been conducted on populations of European (Caucasian) descent,

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Cancer is not like cancer: Ethnic background matters

November 24, 2017 – New research indicates that one-size treatment for one form of blood cancer likely does not fit all, particularly when it comes to ethnic differences of patients.  Thus, African-American men are three times more likely to be diagnosed with multiple myeloma,

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Asthma: An allelic variant of the PYHIN1 gene is unique to African Americans

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SEMA4D gene variant quadruples obesity risk in individuals of African descent

March 26, 2017 – There is ample evidence that the burden of obesity is not the same across ethnic groups. While diet and lifestyle play a large role in determining body weight, there is also a heritable component. Unfortunately,  most prior studies that have evaluated the role of genes in obesity have looked mostly at people of European or Asian descent,

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Adverse clinical outcome associated with mutations in colorectal cancers of African Americans

Colon Cancer in AASeptember 04, 2016 – Case Comprehensive Cancer Center researchers, a research collaboration which includes University Hospitals Seidman Cancer Center and Case Western Reserve University, who last year identified new gene mutations unique to colon cancers in African Americans, have found that tumors with these mutations are highly aggressive and more likely to recur and metastasize.

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  • The co-occurrence of cancer driver genes, key to precision medicine September 22, 2020
    Cancer driver genes are those with mutations that are essential for tumor development and spread. Led by ICREA researcher Patrick Aloy, scientists from the Structural Bioinformatics and Network Biology (SBNB) Laboratory at IRB Barcelona have developed a computational pipeline that predicts tumor response to different cancer treatments. This system is based on the identification of […]
  • Genomic adaptations to a rice-based diet mitigate the risk of obesity and diabetes September 21, 2020
    The traditional rice-based diet of some east-Asian population has brought a number of genomic adaptations that may contribute to mitigating the spread of diabetes and obesity. An international study led by the University of Bologna and published in the journal Evolutionary Applications has recently suggested this interesting hypothesis. Researchers analyzed and compared the genomes of […]
  • Researchers identify genetic factors associated with hand-foot syndrome in chemotherapy with capecitabine September 21, 2020
    Capecitabine is a chemotherapy drug used for breast and colorectal cancer. It can extend survival rate by nearly 10%. However, recent studies revealed that almost 50% of patients develop palmar-plantar erythrodysesthesia, a skin reaction also called hand-foot syndrome with mild to serious symptoms. Up to 17% of these patients can have a burning pain in […]
  • Gene therapy corrects the cardiac effects of Friedreich's ataxia September 18, 2020
    Gene therapy was successfully used to overcome the cardiac effects of Freidreich's ataxia (FA) in a mouse model of the disease, as reported in the peer-reviewed journal Human Gene Therapy.
  • Algorithms uncover cancers' hidden genetic losses and gains September 17, 2020
    Understanding the specific mutations that contribute to different forms of cancer is critical to improving diagnosis and treatment. But limitations in DNA sequencing technology make it difficult to detect some major mutations often linked to cancer, such as the loss or duplication of parts of chromosomes.
  • Thin and ultra-fast photodetector sees the full spectrum September 22, 2020
    Researchers have developed the world's first photodetector that can see all shades of light, in a prototype device that radically shrinks one of the most fundamental elements of modern technology.
  • New drug candidate found for hand, foot and mouth disease September 22, 2020
    Duke researchers have identified a potential drug candidate against enterovirus 71, a common cause of hand, foot and mouth disease in infants and young children. The compound of interest is a small molecule that binds to RNA, the virus's genetic material, and changes its 3-D shape in a way that stops the virus from multiplying […]
  • Web resources bring new insight into COVID-19 September 22, 2020
    Two new web resources put at researchers' fingertips information about cellular genes whose expression is affected by coronavirus infection and place these data points in the context of the complex network of host molecular signaling pathways.
  • New freshwater database tells water quality story for 12K lakes globally September 22, 2020
    Although less than one per cent of all water in the world is freshwater, it is what we drink and use for agriculture. In other words, it's vital to human survival. York University researchers have just created a publicly available water quality database for close to 12,000 freshwater lakes globally - almost half of the […]
  • Nearly 20 percent of americans don't have enough to eat September 22, 2020
    More than 18 percent of US adults do not know whether they will have enough to eat from day to day, and the numbers are worse for Hispanics, Blacks, people with obesity, and women, a new report shows.
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