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Could DNA testing help the most seriously affected Covid-19 patients?

April 28, 2020 – Coronavirus disease 2019 (Covid-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease was first identified in December 2019 in Wuhan, the capital of China’s Hubei province,

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Klotho’s role in some patients with Alzheimer’s disease revealed?

April 24, 2020 – The klotho gene is named after the fanciful Greek goddess of destiny Clotho who turns the string of life known to be related with longer life and improved cognizance. In modern biology, allelic variants of the klotho gene in fact have been associated with long life span.

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The phenotype broker: Blockchain and patient phenotype

July 26, 2019 – “Blockchains for secure digitized medicine”. This is the title of a very interesting and important article in the Journal of Personalised Medine (JPM) as of May 28, 2019.

Blockchain as an emerging technology (particularly around the hype on Bitcoins) has been gaining in popularity,

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Heart disease prediction by traditional risk factors as good as with an exhaustive genetic test

February 20, 2020 – Traditional cardiovascular risk factors often assessed in an annual physical, such as blood pressure, cholesterol levels, diabetes, and smoking status, may at least be as valuable in predicting who will develop coronary heart disease (CHD) as a sophisticated genetic test that surveys millions of different points in DNA,

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How relates lifetime prevalence of skin cancer to sexual orientation

February 16, 2020 – An often asked question is whether there is an association between sexual orientation and lifetime prevalence of skin cancer. According to a cross-sectional study of 845’ 264 adults in the US, just published in JAMA Dermatology as recent as February 12,

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Clinical evidence and implementation challenges for pharmacogenomic testing

September 18, 2019 – This post is an edited version of parts of a paper that appeared in the Journal of Personalised Medicine (JPM) a week ago und which addresses one of the important topics in connection with the themes of personalised medicine,

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Onasemnogene abeparvovec-xioi (Zolgensma): Approval strategy with manipulated data?

August 13, 2019 – Onasemnogene abeparvovec-xioi (Zolgensma) is an adeno-associated virus vector-based gene therapy indicated for the treatment of pediatric patients less than 2 years of age with spinal muscular atrophy (SMA) with bi-allelic mutations in the survival motor neuron 1 (SMN1) gene.

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Cystic fibrosis: CFTR-gene editing may cure this genetic disease

August 13, 2019 – A very significant research article by the title “Allele specific repair of splicing mutations in cystic fibrosis through AsCas12a genome editing” has just appeared in the open access Journal Nature Communications. This work provide hope to patients with cystic fibrosis (CF) that in the nearer future CF may be curable,

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Black people with natural blonde hair – Everything is possible in genetics

August 07, 2019 – Blonde hair is a rare human phenotype found almost exclusively in Europe and Oceania. Human pigmentation varies considerably within and among populations and is a function of both variation in exposure to ultraviolet radiation (UVR) and the type and quantity of melanin produced in melanocytes and keratinocytes.

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ZRANB3 in African Populations: New Type 2 Diabetes risk locus identified

August 03, 2019 – Africa is considered the original cradle of all humanity, to which all humans can trace their genetic origin. This may be very interesting in the context of diseases that are due to genetic predispositions both in todays African populations and in all the populations descendant of African origin worldwide.

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  • Study reveals restoration of retinal and visual function following gene therapy October 19, 2020
    A breakthrough study, led by researchers from the University of California, Irvine, results in the restoration of retinal and visual functions of mice models suffering from inherited retinal disease.
  • Scientists map the human proteome October 19, 2020
    Twenty years after the release of the human genome, the genetic "blueprint" of human life, an international research team, including the University of British Columbia's Chris Overall, has now mapped the first draft sequence of the human proteome.
  • The line of succession in neuron function October 19, 2020
    A specific region of messenger RNAs, the 3' untranslated region (3'UTR), plays an important role for cells to function properly. During embryonic development, 3'UTRs in hundreds of RNAs lengthen exclusively in neurons, which is crucial for the cells of the brain to function properly. The lab of Valérie Hilgers at the Max Planck Institute of […]
  • Pinpointing the 'silent' mutations that gave the coronavirus an evolutionary edge October 16, 2020
    We know that the coronavirus behind the COVID-19 crisis lived harmlessly in bats and other wildlife before it jumped the species barrier and spilled over to humans.
  • Transposons could be rewiring our brains October 16, 2020
    A new study by neuroscientists at the University of Oxford shows that mobile genetic elements that were active in the genomes of our ancestors could be closely linked to important functions in our brain and might help diversify our behavior, cognition and emotions.
  • Asymmetric optical camouflage: Tuneable reflective color accompanied by optical Janus effect October 20, 2020
    Deliverying viewing-direction sensitive information display across single sheet of transreflective window is introduced. Based on the experimental verification of theoretical modelling, scientists in Republic of Korea invented colour tuneable optical device that displays different colours and messages depending on viewing direction which is completely new and exotic optical phenomenon. A step further, they realized asymmetric […]
  • Researchers at the forefront of developing machine learning methods for chemical discovery October 20, 2020
    Prof. Alexandre Tkatchenko and his research team at the University of Luxembourg have been awarded grants totalling 500,000 euros to conduct research in the emerging field of machine learning methods for chemical discoveries.
  • COVID-19: Distancing and masks are not enough October 20, 2020
    Decades-old data is being used to describe the propagation of tiny droplets. Now a fluid dynamics team has developed new models: Masks and distancing are good, but not enough. Even with a mask, infectious droplets can be transmitted over several meters and remain in the air longer than previously thought.
  • Oncotarget: Inhibition of HAS2 and hyaluronic acid production by 1,25-Dihydroxyvitamin D3 in breast October 20, 2020
    Oncotarget Volume 11, Issue 30 reported that genomic profiling of murine mammary tumor cells with differential VDR expression identified 35 transcripts that were altered by the 1,25D3-VDR complex including Hyaluronan Synthase-2.
  • US adults' likelihood of accepting COVID-19 vaccination October 20, 2020
    In this survey study of U.S. adults, vaccine-related attributes and political characteristics were associated with self-reported preferences for choosing a hypothetical COVID-19 vaccine and self- reported willingness to receive vaccination. These results may help inform public health campaigns to address vaccine hesitancy when a COVID-19 vaccine becomes available.
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