Genetic Background

Blog Archives

Onasemnogene abeparvovec-xioi (Zolgensma): Approval strategy with manipulated data?

Posted on August 13, 2019 by by

thassodotcom Posted in Allelic Variant, Gene Therapy, Genetic Background, In The Press, Personomics, Thasso Post, Theragenomic Medicine No Comments ↓

August 13, 2019 – Onasemnogene abeparvovec-xioi (Zolgensma) is an adeno-associated virus vector-based gene therapy indicated for the treatment of pediatric patients less than 2 years of age with spinal muscular atrophy (SMA) with bi-allelic mutations in the survival motor neuron 1 (SMN1) gene.

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Cystic fibrosis: CFTR-gene editing may cure this genetic disease

Posted on August 13, 2019 by by

thassodotcom Posted in Congenital, Gene Editing, Gene Therapy, Genetic Background, New Research, Personomics, Thasso Post, Theragenomic Medicine No Comments ↓

August 13, 2019 – A very significant research article by the title “Allele specific repair of splicing mutations in cystic fibrosis through AsCas12a genome editing” has just appeared in the open access Journal Nature Communications. This work provide hope to patients with cystic fibrosis (CF) that in the nearer future CF may be curable,

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ZRANB3 in African Populations: New Type 2 Diabetes risk locus identified

Posted on August 3, 2019 by by

thassodotcom Posted in Ethnicity, Genetic Background, Genetic Predisposition, Genetic Susceptibility, Personalized Medicine, Personomics, Thasso Post, Theragenomic Medicine No Comments ↓

August 03, 2019 – Africa is considered the original cradle of all humanity, to which all humans can trace their genetic origin. This may be very interesting in the context of diseases that are due to genetic predispositions both in todays African populations and in all the populations descendant of African origin worldwide.

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Risk loci for post-traumatic stress disorder (PTSD)

Posted on August 1, 2019 by by

thassodotcom Posted in Allelic Variant, Ethnicity, Genetic Background, Genetic Predisposition, New Research, Thasso Post, Theragenomic Medicine No Comments ↓

August 01, 2019 – Post-Traumatic Stress Disorder (PTSD) is a mental disorder that can develop after a person is exposed to a traumatic event, such as sexual assault, warfare, traffic collisions, or other threats on a person’s life. Symptoms may include disturbing thoughts,

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Genetic aspects of globesity: Glocalized or not?

Posted on June 25, 2019 by by

thassodotcom Posted in Allelic Variant, Gene Expression, Genetic Background, Genetic Predisposition, Genetic Susceptibility, New Research, Personomics, Thasso Post, Theragenomic Medicine No Comments ↓

June 25, 2019 – The global obesity epidemic is so far-reaching it now has an overarching name: globesity (obviously derived from global obesity). Very interesting questions arise in this context such as are there glocalized (global and or local) factors involved in this epidemic.

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Status of genetics behind male infertility

Posted on June 20, 2019 by by

thassodotcom Posted in Genetic Background, Genetic Predisposition, Genetic Susceptibility, New Research, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

June 20, 2019 – Male infertility is a serious treat in very many relations. While a priori, male infertility does not affect the physical health of the afflicted, it may very much affect the psychological health of the individual, and that of couples too.

In recent years,

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Where portrait photos meet genetics and AI

Posted on June 13, 2019 by by

thassodotcom Posted in Clinical Development, Digital Health, Genetic Background, Genetic Predisposition, In The Press, Neue Forschung, On The Horizon, Thasso Post, Theragenomic Medicine No Comments ↓

June 13, 2019 – This is simply fascinating stuff. Researchers are testing neural networks that automatically combine portrait photos with genetic and phenotypic patient data in order to obtain definitive diagnosis of hereditary rare diseases, all with the help of artificial intelligence (AI).

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Calcium deficiency in cells due to ORAI1 gene mutation leads to damaged tooth enamel

Posted on April 28, 2019 by by

thassodotcom Posted in Allelic Variant, Genetic Background, Genetic Predisposition, New Research, Thasso Post, Theragenomic Medicine No Comments ↓

April 28,

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Tags: Ameloblast, Calcium Channel, Calcium Influx, Enamel Cells, ORAI1 Gene, ORAI2 Gene, ORAI3 Gene, Thasso Post, Theragenomic Medicine, Tooth Enamel

Genomics lab illegally markets genetic tests that claim to predict patient responses to drugs

Posted on April 7, 2019 by by

thassodotcom Posted in Allelic Variant, Genetic Background, Genetic Predisposition, Genetic Susceptibility, Pharmacogenetics, Regulatory Announcement, Thasso Post, Theragenomic Medicine No Comments ↓

April 07, 2019 – Consumers are increasingly embracing genetic testing to better understand their individual risk for developing diseases. With this rise in popularity and availability, we’re also seeing significant activity in the field of pharmacogenetics, which is the process of understanding what, if any, role genetics plays in a patient’s reaction to particular drugs,

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Your genes and your opioids: Pain relief or addiction? Or both?

Posted on March 14, 2019 by by

thassodotcom Posted in Genetic Background, Genetic Predisposition, Genetic Susceptibility, Thasso Post, Theragenomic Medicine No Comments ↓

March 14, 2019 – Genetic predisposition may help to explain opioid based pain relief, addiction, or the combination of both. In a perfect world, and in battling the rampant opioid crises in the US and other parts of the world, doctors would be able to identify those patients who are prone to opioid addiction and prescribe them non-opioid painkillers that wouldn’t lead to dependence.

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