Genetic Background

Blog Archives

Tapping into the massive potential of African genomes: 54gene

Posted on February 22, 2020 by by

Joseph Gut - thasso Posted in Genetic Background, In The Press, On The Horizon, Thasso Post, Theragenomic Medicine No Comments ↓

February 22, 2020 – Genetic studies rely almost entirely on genomes from people of Caucasian descent. While all around the world, tissue and blood banks have sprung up to catalog human genome’s many mysteries, this was not the case for Africa. Until now,

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Tags: 54gene, African Descent, African Genome, Caucasian Descent, Genetic Diversity, Nigerian Sart-Up, Thasso Post, Theragenomic Medicine

Heart disease prediction by traditional risk factors as good as with an exhaustive genetic test

Posted on February 20, 2020 by by

Joseph Gut - thasso Posted in Genetic Background, Genetic Predisposition, Genetic Susceptibility, Personalized Medicine, Personomics, Thasso Post, Theragenomic Medicine No Comments ↓

February 20, 2020 – Traditional cardiovascular risk factors often assessed in an annual physical, such as blood pressure, cholesterol levels, diabetes, and smoking status, may at least be as valuable in predicting who will develop coronary heart disease (CHD) as a sophisticated genetic test that surveys millions of different points in DNA,

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Tags: Atherosclerosis, Atherosclerosis Risk in Communities (ARIC), Blood Pressure, Cholesterol Level, Clinical Phenotype, Coronary Heart Disease (CHD), Diabetes, DNA, Genetic Background, Genetic Testing, Genetic Variation, Heart Attack, Multi-Ethnic Study of Atherosclerosis (MESA), Myocardial Infarction, Prospective Risk Prediction, Smoking, Smoking Status, Thasso Post, Theragenomics Medicine, Traditional Risk Factor

Brain, Body Incongruence in Transgenders: Gene Variants Provide Some Insights

Posted on February 6, 2020 by by

Joseph Gut - thasso Posted in Allelic Variant, Genetic Background, New Research, Personomics, Thasso Post, Theragenomic Medicine No Comments ↓

February 06, 2020 – Some of the first biological evidence of the incongruence transgender individuals experience, because their brain indicates they are one sex and their body another, may have been found in estrogen receptor pathways in the brain of 30 transgender individuals.

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Tags: AKR1C3 Gene, Allelic Variant, Androgen, BOK Gene, CDH8 Gene, CDK12 Gene, CTNNA2 Gene, DNER Gene, DSCAML1 Gene, EFHD2 Gene, EGF Gene, Estrogen, Gender Dysphoria, Genetic Variant, GRIN1 Gene, Incongruence, KCNK3 Gene, MAP4K3 Gene, Masculinization, PIK3CA Gene, PPARGC1B Gene, RIMS3 Gene, RIMS4 Gene, SPHK1 Gene, SYNPO Gene, Thasso Post, Theragenomic Medizine, TNN Gene, Transgender

East Asians, Europeans: Genomic Features of Lung Adenocarcinoma Differ

Posted on February 5, 2020 by by

Joseph Gut - thasso Posted in Ethnicity, Genetic Background, Thasso Post, Theragenomic Medicine No Comments ↓

February 05, 2020 – Lung adenocarcinoma is a common cancer and leads to more than one million deaths each year, Lung tumors isolated from adenocarcinoma patients of East Asian ancestry have a less complex genomic architecture than tumors from European patients, a new study has found.

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Tags: EGFR Gene, Lung Adenocarcinoma, Proximal Inflammatory Subclusters (PIS), Terminal Respiratory Unit (TRU), Thasso Post, Theragenomic Medicine, TP53 Gene, Transcriptomic Profile, Tumor Genome

Soccer Headers Might Be More Risky for APOE4 Genotype Carriers

Posted on February 1, 2020 by by

Joseph Gut - thasso Posted in Allelic Variant, Genetic Background, Genetic Predisposition, Genetic Susceptibility, In The Press, New Research, Thasso Post, Theragenomic Medicine No Comments ↓

February 01, 2020 – Soccer headers might be more risky for APOE4 genotype carriers – this is the headline of a very recent Reuters Health article appearing in Medscape. Thus, soccer players with apolipoprotein E4 (APOE4) genotype may want to limit how many headers they do,

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Tags: Allelic Variant, APOE4 Gene, APOE4 Genotype, Chronic Traumatic Encephalopathy (CTE), Genetic Predisposition, Genetic Risk Factor, Neurodegeneration, Risk Gene, Thasso Post, Theragenomic Medicine

The diversity of Asian genomes

Posted on January 26, 2020 by by

Joseph Gut - thasso Posted in Allelic Variant, Ethnicity, Genetic Background, Genetic Predisposition, Genetic Susceptibility, New Research, Thasso Post, Theragenomic Medicine, Theragenomics 1 Comment ↓

January 26, 2020 – An effort to map thousends of genomes across Asia has certainly the potential to find novel gene variants affecting disease and responses to drugs, and to reveal the complex origins of Asian populations.

In a pilot study,

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Tags: Allelic Variant, Asian Origin, Asian Population, Ethnicity, Gene Variant, Genetic Diversity, Thasso Post, Theragenomic Medicine

Is laziness a personal choice or a genetic trait?

Posted on November 2, 2019 by by

Joseph Gut - thasso Posted in Genetic Background, Genetic Predisposition, New Research, Thasso Post, Theragenomic Medicine 1 Comment ↓

November 02, 2019 – Is laziness a choice or genetic trait? At the age where genetics seems to explain everything, it is certainly interessant to learn that a seemingly personal choice such as laziness as such may loom somewhere in your genetic outfit. Perhaps, you can not escape your laziness behaviour,

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Tags: Genetic Predisposition, Laziness, Personal Choice, PKIA Gene, Thasso Post, Theragenomics Medicine

After an over the counter genetic test: Would you make serious health decisions?

Posted on October 27, 2019 by by

Joseph Gut - thasso Posted in Allelic Variant, Genetic Background, Genetic Predisposition, Genetic Susceptibility, Thasso Post, Theragenomic Medicine No Comments ↓

October 27, 2019 – Genetic tests sold online and in shops are en vogue. More and more patients strive for it, and they (the patients) are getting back results. Results, the normal patient has no chance to understand. Not even most of treating physicians are capable to interpret in favour of their patients.

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Tags: Clinical Phenotype, Compound Heterozytoges, Confounding Factors, Direct To Consumer Genetic Testing (DTCGT), Direct To Consumer Theragenomic Testing (DTCTT), False Negative Results, False Positive Results, Genotype, Molecular Phenotype, Pharmacogenomics, Thasso Post, Theragenomic Medicine, Theragenomics, Transcriptional Bursting

Hidden secrets in African genomes revealed by large scale sequencing

Posted on October 20, 2019 by by

Joseph Gut - thasso Posted in Ethnicity, Genetic Background, Genetic Predisposition, Genetic Susceptibility, Thasso Post, Theragenomic Medicine No Comments ↓

October 20, 2019 – Sequencing African genomes yields new data resource with broad applicability. By collaborating globally in a new, large-scale effort, researchers have made strong progress in sequencing genomes from regions and countries across Africa. These findings will enable more broadly representative and relevant studies ranging from basic through clinical genetics.

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Tags: African Population, Ethnicity, Ethnolinguistic Group, Genetic Diversity, Genetic Predisposition, Genetic Susceptibility, H3Africa, Human Heredity and Health in Africa Consortium (H3Africa), Natural Selection, Survival Of The Fittest, Thasso Post, Theragenomic Medicine, Viral Infection

Clinical evidence and implementation challenges for pharmacogenomic testing

Posted on September 18, 2019 by by

Joseph Gut - thasso Posted in Allelic Variant, Genetic Background, Genetic Predisposition, Genetic Susceptibility, Personalized Medicine, Personomics, Pharmacogenetics, Thasso Post, Theragenomic Medicine No Comments ↓

September 18, 2019 – This post is an edited version of parts of a paper that appeared in the Journal of Personalised Medicine (JPM) a week ago und which addresses one of the important topics in connection with the themes of personalised medicine,

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