the new generation glocalized patient network in theragenomic and personalized medicine and individualized drug safety
May 08, 2022 – Umbralisib (Ukoniq) is a medication for the treatment of marginal zone lymphoma (MZL) and follicular lymphoma (FL). Umbralisib (Ukoniq) inhibits multiple kinases. In biochemical and cell-based assays, Umbralisib inhibited PI3Kδ and casein kinase CK1ε. PI3Kδ is expressed in …
Umbralisib (Ukoniq): Drug recall because increased risk of patient death Read more »
July 14, 2021 – Why does a SARS-CoV-2 infection make some people so sick with Covid-19 disease? And why do some infected people barely fall ill if at all? The answer may be that you have to talk to their …
Genetic susceptibility and severity loci for Covid-19 disease Read more »
June 30, 2021 – This post is based on an overview given by the Centers of Disease Control (CDC) of the United States on the current knowledge on the occurrence of severe adverse effects (SAE) after anti-Covid-19 vaccination as reported …
Serious adverse events after Covid-19 vaccination occur but are very rare Read more »
March 28, 2021 – Recent reports from the United Kingdom (UK) and from throughout the European Union (EU) have suggested that the SARS-CoV-2 (Covid-19) vaccine made by AstraZeneca was at the origin of the development of a very rare type …
Covid-19 Vaccines: Is there genetic predisposition for thrombosis? Read more »
February 08, 2021 – In the period of the Covid-19 pandemic and the emerging spectrum of severe adverse (drug) reactions (SADRs) of the anti-Covid-19 vaccines in some patients receiving these vaccines, one easily forgets about the same phenomenon of SADRS …
Fingolimod (Gilenya): Warnings on severe liver failures Read more »
January 26, 2021 –Â To date, a rare serious adverse (drug) reaction (SADR) has been noted to be associated with the first two Covid-19 vaccines, i.e., the one from Pfizer-BioNTech and the one from Moderna. We are talking about anaphylaxis, which …
Rare cases of anaphylaxis with COVID-19 vaccines Read more »
December 28, 2020 – Some 95% of people have gene variants that may negatively affect their response to at least one drug, leading to unexpected or adverse drug reactions (ADRs) or, if unlucky, to a serious, if not fatal, adverse …
Genetics behind some serious adverse drug reactions (SADRs) Read more »
August 26 2020 – Â Vascular endothelial growth factor (VEGF), originally known as vascular permeability factor (VPF)Â Â is a signal protein produced by cells that stimulates the formation of blood vessels. VEGF is a sub-family of growth factors, the platelet-derived growth factor …
Increased Risk Of Aneurysms And Artery Dissections With VEGF Inhibitors Read more »
March 25, 2020 – The Covid-19 pandemic keeps the word abreast. Drastic measures have been and are being taken worldwide by governments, hospitals, healthcare  care providers, and retiring homes in attempts to halt the spreading of Covid-19 disease. Recently, there have …
Covid-19 disease: Be careful with chloroquine and hydroxychloroquine Read more »
March 10, 2020 – A widespread assumption is, the people of Asian descent are more prone to serious, sometimes deadly adverse drug reactions, even when taking rather common medications prescribed for gout through to depression. In the ages of genetics …
Are Asians at higher genetic risk of serious adverse events to common medications? Read more »