December 22, 2022 – Are the many effects of ketamine clinically manageable? For treating clinicians and their patients receiving ketamine for quite a number of indications such as starting and maintaining general anesthesia, some forms of chronic pain relief, and some types …

Ketamine, Depression, Addiction: Is it a Cure, a Cause or a Vicious Cycle? Read more »

November 20, 2022 – The genetics of drug side-effects. Some 95% of people have a gene variant that affects their response to at least one drug. Treating physicians, clinical researchers, and affected patients know all to well the serious problems that …

Is there pre-emptive genotyping to avoid adverse drug effects (ADRs)? Read more »

October 14, 2022 – “Gambia Police Link Child Deaths to Cough Syrups Imported by US Firm”. This is a report from Reuters that illustrates in a tragic fashion the problem of globalisation of all processes involved in providing medicines to the needing …

The Gambia: Childrens deaths due to cough syrups Read more »

August 26, 2022 – Traditionally, pharmacovigilance (PV), is the pharmaceutical science relating to the “collection, detection, assessment, monitoring, and prevention” of adverse drug reactions (ADRs) with pharmaceutical products and associated therapies. Pharmacovigilance is based on information about ADRs received from patients and healthcare …

Pharmacogenovigilance: Has the time come? Read more »

August 21, 2022 – Systemic lupus erythematosus (SLE) is a common, incurable autoimmune disease that affects millions of individuals worldwide, with a particularly high prevalence among women. A genetic variant, called HLA-DRB1*03:01, is the greatest risk factor for the condition, …

Serious lupus: Strong genetic risk factor on its path Read more »

25 June 2022 – Xalkori (Crizotinib)-related ocular toxicity and severe visual loss are difficult to detect in children. This comes out of a Dear Healthcare Professional Communication (DHPC) letter from the European Medicine Agency (EMA) following it’s June 2022 Pharmacovigilance Risk Assessment …

Xalkori: Ocular Toxicity and Severe Visual Loss in Children Read more »

13 June 2022 – Sometimes, patients genetics can be bewildering and/or unjust. Common belief with patients and the general public would be that genetic variants would be responsible for causing all kinds of adverse drug reactions (ADR’s) and be at the …

Rare APOE genetic variants reduce Alzheimer’s risk Read more »

09 June 2022 – The individium in general and the patient in the context discussed here, are the phenotype experts on their forms of proper disease they are suffering from. It is not their treating physician, it is not a …

Just a reminder: Thasso and the apomediary patient Read more »

May 08, 2022 – Umbralisib (Ukoniq) is a medication for the treatment of marginal zone lymphoma (MZL) and follicular lymphoma (FL). Umbralisib (Ukoniq) inhibits multiple kinases. In biochemical and cell-based assays, Umbralisib inhibited PI3Kδ and casein kinase CK1ε. PI3Kδ is expressed in …

Umbralisib (Ukoniq): Drug recall because increased risk of patient death Read more »

July 14, 2021 – Why does a SARS-CoV-2 infection make some people so sick with Covid-19 disease? And why do some infected people barely fall ill if at all? The answer may be that you have to talk to their …

Genetic susceptibility and severity loci for Covid-19 disease Read more »