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Cystic fibrosis: CFTR-gene editing may cure this genetic disease

Posted on August 13, 2019 by by

thassodotcom Posted in Congenital, Gene Editing, Gene Therapy, Genetic Background, New Research, Personomics, Thasso Post, Theragenomic Medicine No Comments ↓

August 13, 2019 – A very significant research article by the title “Allele specific repair of splicing mutations in cystic fibrosis through AsCas12a genome editing” has just appeared in the open access Journal Nature Communications. This work provide hope to patients with cystic fibrosis (CF) that in the nearer future CF may be curable,

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Tags: 3272–26A>G CTFR Gene Mutation, 3849+10kbC>T CFTR Gene Mutation, CFTR Gene, CFTRΔF508, CRISPR-Cas9, Cystic Fibrosis (CF), Gene Correction, Gene Editing, Gene Mutation, Gene Splicing, Gene Therapy Clinical Trials, Thasso Post, Theragenomic Medizine

Black people with natural blonde hair – Everything is possible in genetics

Posted on August 7, 2019 by by

thassodotcom Posted in Allelic Variant, Ethnicity, Genetic Predisposition, New Research, Personomics, Thasso Post, Theragenomic Medicine No Comments ↓

August 07, 2019 – Blonde hair is a rare human phenotype found almost exclusively in Europe and Oceania. Human pigmentation varies considerably within and among populations and is a function of both variation in exposure to ultraviolet radiation (UVR) and the type and quantity of melanin produced in melanocytes and keratinocytes.

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Tags: African Ancestry, Allelic Variant, Autosomal Recessive, Blonde Hair, Genetic Predisposition, Genetic Variant, Genome Wide Association Study (GWA), Genotyp [Homozygot], Inheritance, Melanesian People, Melanin, Oceania, Solomon Islands, Thasso Post, Theragenomics Medicine, Tyrosinase-Related Protein 1, TYRP1 Gene, Years Before Present (YBP)

Risk loci for post-traumatic stress disorder (PTSD)

Posted on August 1, 2019 by by

thassodotcom Posted in Allelic Variant, Ethnicity, Genetic Background, Genetic Predisposition, New Research, Thasso Post, Theragenomic Medicine No Comments ↓

August 01, 2019 – Post-Traumatic Stress Disorder (PTSD) is a mental disorder that can develop after a person is exposed to a traumatic event, such as sexual assault, warfare, traffic collisions, or other threats on a person’s life. Symptoms may include disturbing thoughts,

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Tags: African American, Ethnicity, European American, Phenotype, Post-Traumatic Stress Disorder (PTSD), Risk Locus, Thasso Post, Theragenomics Medicine, Transcriptomic Profile

The phenotype broker: Blockchain and patient phenotype

Posted on July 26, 2019 by by

thassodotcom Posted in New Research, On The Horizon, Personalized Medicine, Personomics, Targeted Therapy, Thasso Post, Theragenomic Medicine No Comments ↓

July 26, 2019 – “Blockchains for secure digitized medicine”. This is the title of a very interesting and important article in the Journal of Personalised Medine (JPM) as of May 28, 2019.

Blockchain as an emerging technology (particularly around the hype on Bitcoins) has been gaining in popularity,

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Tags: Allelic Variants, Apomediary Patient, Bitcoin, Blockchain, Digital Medicine, Electronic Medical Records (EMR), Free Health Data Market (FHDM), Genetic Variants, Genetics, Genotypes, Journal of Personalised Medine (JPM), Patient Phenotype, Personalized Medicine, Phenotype, Phenotype Broker, Thasso Post, Theragenomic Medicine, Third Trusted Party (TTP)

Genetic aspects of globesity: Glocalized or not?

Posted on June 25, 2019 by by

thassodotcom Posted in Allelic Variant, Gene Expression, Genetic Background, Genetic Predisposition, Genetic Susceptibility, New Research, Personomics, Thasso Post, Theragenomic Medicine No Comments ↓

June 25, 2019 – The global obesity epidemic is so far-reaching it now has an overarching name: globesity (obviously derived from global obesity). Very interesting questions arise in this context such as are there glocalized (global and or local) factors involved in this epidemic.

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Tags: Allelic Variant, Congenital Leptin Deficiency, Fat Controller, Globesity, Glocalization, LEP Gene, Leptin, Metreleptin [Myalept], Recessive Genetic Disorder, Thasso Post, Theragenomic Medicine

Status of genetics behind male infertility

Posted on June 20, 2019 by by

thassodotcom Posted in Genetic Background, Genetic Predisposition, Genetic Susceptibility, New Research, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

June 20, 2019 – Male infertility is a serious treat in very many relations. While a priori, male infertility does not affect the physical health of the afflicted, it may very much affect the psychological health of the individual, and that of couples too.

In recent years,

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Tags: Acrosome Biogenesis, CFAP43 Gene, CFAP44 Gene, DNAH1 Gene, DPY19L2 Gene, Endocrine Disruptor, Male Infertility, Multiple Morphological Anomalies of the Flagellum (MMAF Syndrome), RBMXL2 Gene, SPINK2 Gene, Thasso Post, Theragenomics Medicine

Creative dancing and the genetic predisposition of it

Posted on May 6, 2019 by by

thassodotcom Posted in Genetic Predisposition, New Research, Thasso Post, Theragenomic Medicine No Comments ↓

May 06, 2019 – Dancing, integrally related to music, likely has its origins close to the birth of Homo sapiens. Some researchers for a long time have hypothesized that there are differences in aptitude, propensity, and need for dancing that may be based on differences in common genetic polymorphisms.

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Tags: AVPR1A Gene, Cloninger's Tridimensional Personality Questionnaire, Dance, Dancing Phenotype, Phenotype, Serotonin Transporter, SLC6A4 Gene, Tellegen Absorption Scale, Thasso Post, Theragenomic Medicine, Vasopressin Receptor

Calcium deficiency in cells due to ORAI1 gene mutation leads to damaged tooth enamel

Posted on April 28, 2019 by by

thassodotcom Posted in Allelic Variant, Genetic Background, Genetic Predisposition, New Research, Thasso Post, Theragenomic Medicine No Comments ↓

April 28,

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Tags: Ameloblast, Calcium Channel, Calcium Influx, Enamel Cells, ORAI1 Gene, ORAI2 Gene, ORAI3 Gene, Thasso Post, Theragenomic Medicine, Tooth Enamel

Direct Oral Anticoagulants (DOAC): Newly Identified Genes and Genetic Variants

Posted on January 26, 2019 by by

thassodotcom Posted in Drug/Drug Interaction, Genetic Background, New Research, Pharmacogenetics, Thasso Post, Theragenomic Medicine No Comments ↓

January 26, 2019 – Pharmacogenomic approaches are increasingly revealing newly identified genes and genetic variants that are at the base of remarkable inter-individual pharmacokinetic and pharmacodynamic variation of novel direct oral anticoagulants (DOAC).

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Tags: ABCB1 Gene, Apixaban (Eliquis), CES1 Gene, CYP2C9 Gene, CYP3A4 Gene, Dabigatran [Pradaxa], Direct Oral Anticoagulants (DOAC), Drug-Drug Interaction, Edoxaban (Savaysa), Factor Xa Gene, Genetic Locus, Genetic Variants, Idarucizumab (Praxbind), P-glycoprotein, Rivaroxaban (Xarelto), Single-Nucleotide Polymorphism (SNP), SLCOB1 Gene, Thasso Post, Theragenomic Medicine, VKORC1 Gene

Combined hormonal contraception: Is there an unacceptable health risk?

Posted on January 15, 2019 by by

thassodotcom Posted in Genetic Predisposition, New Research, Thasso Post, Theragenomic Medicine No Comments ↓

January 15, 2019 – The World Health Organization (WHO) classifies combined hormonal contraception as an unacceptable health risk in the presence of a known thrombogenic mutation but advises against routine thrombophilia genetic testing before initiating combined oral contraceptives (COC’s) on the grounds of high screening costs and low prevalence.