Blog Archives

The phenotype broker: Blockchain and patient phenotype

July 26, 2019 – “Blockchains for secure digitized medicine”. This is the title of a very interesting and important article in the Journal of Personalised Medine (JPM) as of May 28, 2019.

Blockchain as an emerging technology (particularly around the hype on Bitcoins) has been gaining in popularity,

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Direct-to-Consumer Genetic Testing: Are Patients Ready?

March 31, 2018 – Are patients ready for direct-to-consumer genetic testing?  This was the very important and central question that came up in the article by Matt Smith on Medscape, published March 29, 2018.

Since thasso is all about theragenomic and personalized medicine  and individualized drug safety (i.e.

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Precision Medicine Initiative: draft guidances issued

July 9, 2016 – This is a huge step into the future of theragenomic and personalized medicine and individualized drug safety. In support of the President’s Precision Medicine Initiative (PMI), the American Food & Drug Administration (FDA) just issued two draft guidances that,

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Theragenomic Medicine: Palbociclib (Ibrance) approved for postmenopausal women with advanced (metastatic) breast cancer

February 8, 2015 – The American Food and Drug Administration (FDA) has granted accelerated approval to Palbociclib (Ibrance) to treat advanced (metastatic) breast cancer.  The FDA granted Ibrance breakthrough therapy designation because the sponsor demonstrated through preliminary clinical evidence that the drug may offer a substantial improvement over available therapies.

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India steps closer to Personalized Medicine

July 01, 2014 – As the knowledge of genetics and genomics rapidly expand, a personalized approach to health care is becoming increasingly important. India is fast becoming a promising contender in the global healthcare arena The majority of the global healthcare industry is ready to offer solutions for the masses.

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The Apomediary [Patient Expert] and Personalized Medicine: A Commentary

June 22, 2014 – The individuum (i.e., patient) is the phenotype expert on her/his individualized form of proper disease she/he is suffering from. It is not her/his treating physician, it is not a regulatory person concerned with the safety and efficacy of the medication geared towards treating her/his condition,

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Apple plan to revolutionize mobile healthcare: Personalized medicine at the horizon on the iPhone and the likes

Apple has unveiled HealthKit, a platform to centralise data from different types of devices, like fitness trackers, heart rate and blood pressure monitors.

iphone healthLaunching iOS 8 for iPhones and iPads, which it describes as the biggest release since the launch of the App Store,

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FDA approves Siltuximab [Sylvant] for rare Castleman’s disease

April 23, 2014 – The U.S. Food and Drug Administration today approved Sylvant (siltuximab) to treat patients with multicentric Castleman’s disease (MCD), a rare disorder similar to lymphoma (cancer of the lymph nodes).

MCD causes an abnormal overgrowth of immune cells in lymph nodes and related tissues in the body.

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Can We Identify Risk for Drug Toxicity?

October 10, 2013 – Very recently, David Kerr, Professor of Cancer Medicine at University of Oxford, in the United Kingdom, and past President of the European Society for Medical Oncology, talked on Medscape (see the video here) about risk-benefit analyses for novel, inventive cancer treatments. See here in italics his statement:

 When we talk about precision medicine and personalized medicine,

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EMA: Public consultation open on concept paper on pharmacogenomics in evaluation of authorised medicines

January 26, 2012 – I am relaying the information below by the EMA to the readers of this blog. It might be interessting to dwell into this concept paper (as a scientist, a treating physician, or an informed patient) for informations only or even for commenting.

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 The European Medicines Agency (EMA) has released a concept paper on the development of a guideline on the evaluation of pharmacogenomic methodologies in the evaluation of authorised medicines for public consultation.

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  • Findings in mice reveal possibilities for fetal drug therapy for deafness April 6, 2020
    New research led by hearing scientists at Oregon Health & Science University suggests an avenue to treat and prevent intractable genetic disorders before birth.
  • Study of rare genetic disorder that effects the eyes April 3, 2020
    Nagano prefecture is home to a group of people affected with a rare genetic neurodegenerative disorder called familial amyloid polyneuropathies (FAP). This disease impacts the gene encoding protein transthyretin (TTR) which is produced in the liver and also eyes. Liver transplants are often a treatment for this disease, but severe eyesight problems such as cloudiness […]
  • Natural sunscreen gene influences how we make vitamin D April 2, 2020
    Genetic variations in the skin can create a natural sunscreen, according to University of Queensland researchers investigating the genes linked with vitamin D.
  • Single mutation leads to big effects in autism-related gene April 2, 2020
    A new study in Neuron offers clues to why autism spectrum disorder (ASD) is more common in boys than in girls. National Institutes of Health scientists found that a single amino acid change in the NLGN4 gene, which has been linked to autism symptoms, may drive this difference in some cases. The study was conducted […]
  • Lifestyle changes could delay memory problems in old age, depending on our genes April 2, 2020
    Researchers from King's College London have shown that how we respond to changes in nutrients at a molecular level plays an important role in the aging process, and this is directed by some key genetic mechanisms.
  • Fiber consumption linked to lower breast cancer risk April 6, 2020
    Consuming a diet high in fiber was linked with a reduced incidence of breast cancer in an analysis of all relevant prospective studies. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society (ACS).
  • Stronger Atlantic currents drive temperate species to migrate towards the Arctic Ocean April 6, 2020
    The Arctic Ocean increasingly resembles the Atlantic, not only regarding its temperature but also the species that live there. However, scientists from the CNRS and Université Laval, Quebec showed that an unprecedented strengthening of Atlantic currents is playing a major role in this phenomenon called 'Atlantification.' The research team studied Emiliania huxleyi, a marine microalgae […]
  • Viruses don't have a metabolism; but some have the building blocks for one April 6, 2020
    'Giant viruses' are many times larger than typical viruses and have more complex genomes. Using publicly available metagenome data, researchers at Virginia Tech assembled genomes for more than 500 giant viruses and found a surprising number of genes for cellular metabolic cycles, including glycolysis, gluconeogenesis, and the TCA cycle. Viruses may deploy these genes to […]
  • AI techniques used to improve battery health and safety April 6, 2020
    Researchers have designed a machine learning method that can predict battery health with 10x higher accuracy than current industry standard, which could aid in the development of safer and more reliable batteries for electric vehicles and consumer electronics.
  • Evaluating grip strength to identify early diabetes April 6, 2020
    A new study in the American Journal of Preventive Medicine, published by Elsevier, reports valuable new grip strength metrics that provide healthcare practitioners with an easy-to-perform, time-efficient screening tool for type 2 diabetes (T2DM).
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