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Genetic variants of the NUDT15 gene drive toxicity in leukemia therapy

February 27, 2020 – Thiopurines are important antimetabolite drugs, which make up a critical part of curative treatment for ALL. Genetic variations can directly influence drug and effectiveness of thiopurines. Researchers at St. Jude and elsewhere previously identified NUDT15 variants as a major genetic cause of toxicity during thiopurine therapy,

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Heart disease prediction by traditional risk factors as good as with an exhaustive genetic test

February 20, 2020 – Traditional cardiovascular risk factors often assessed in an annual physical, such as blood pressure, cholesterol levels, diabetes, and smoking status, may at least be as valuable in predicting who will develop coronary heart disease (CHD) as a sophisticated genetic test that surveys millions of different points in DNA,

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Chocolate and the sweet taste receptor gene TAS1R2

January 31, 2018 – Chocolate and the sweet taste receptor gene TAS1R2 may make the life of some obese children and adolescents rather difficult in that genetic variations in TAS1R2 appear related to chocolate powder and dietary fiber intake in these young individuals.

This comes out of a study by a research team at the Faculty of Medicine,

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What your nose shape might tell you

March 19, 2017 – The evolutionary reasons for variation in nose shape across human populations have been subject to continuing debate. An import function of the nose and nasal cavity is to condition inspired air before it reaches the lower respiratory tract. For this reason,

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  • Silencing gene expression to cure complex diseases October 26, 2020
    Many people think of new medicines as bullets, and in the pharmaceutical industry, frequently used terms like "targets" and "hits" reinforce that idea. Immuneering co-founder and CEO Ben Zeskind '03, Ph.D. '06 prefers a different analogy.
  • Bits of genetic material called microRNAs may drive metabolic disorders October 26, 2020
    In a study published today in the journal Cell, UC Berkeley Nutritional Sciences and Toxicology professor Anders Näär led a group of researchers from 12 institutions in the United States and Europe, to better understand a region on the second human chromosome previously linked to both the digestion of milk and metabolic disorders. They discovered […]
  • New York City's coronavirus outbreak spread from more European sources than first reported October 26, 2020
    The COVID-19 pandemic started earlier than previously thought in New York City and Long Island by dozens of people infected mostly with strains from Europe. A new analysis also shows that most of the spread was within the community, as opposed to coming from people who had traveled.
  • Cause of Alzheimer's disease traced to mutation in common enzyme October 26, 2020
    Researchers from Tokyo Metropolitan University have discovered a new mechanism by which clumps of tau protein are created in the brain, killing brain cells and causing Alzheimer's disease. A specific mutation to an enzyme called MARK4 changed the properties of tau, usually an important part of the skeletal structure of cells, making it more likely […]
  • Researchers uncover crucial gene for growth of Ewing sarcoma October 23, 2020
    Researchers at the Institut de Recerca Sant Joan de Déu (IRSJD) in collaboration with those at Center for Genomic Regulation (CRG) have discovered that RING1B is a critical gene for the development of Ewing sarcoma, a rare type of developmental cancer that presents in bones and soft tissues. This newly uncovered epigenetic vulnerability in Ewing […]
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