Theragenomic Medicine

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HSD3B1 Genotype Predicts Prostate Cancer Outcomes

Posted on February 28, 2020 by by

Joseph Gut - thasso Posted in Allelic Variant, Genetic Background, Genetic Predisposition, New Research, Thasso Post, Theragenomic Medicine No Comments ↓

February 28, 2020 – A very recent report elucidates the possible prospective power of the knowledge about the genetic background of patients when concerned with certain clinical endpoints (disease states) and associated genes.

The researchers in the present study analyzed outcomes in white men enrolled in the E3805 CHAARTED clinical trial according to HSD3B1 genotype,

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Genetic variants of the NUDT15 gene drive toxicity in leukemia therapy

Posted on February 27, 2020 by by

Joseph Gut - thasso Posted in Allelic Variant, Genetic Background, Genetic Predisposition, New Research, Thasso Post, Theragenomic Medicine No Comments ↓

February 27, 2020 – Thiopurines are important antimetabolite drugs, which make up a critical part of curative treatment for ALL. Genetic variations can directly influence drug toxicity and effectiveness of thiopurines. Researchers at St. Jude and elsewhere previously identified NUDT15 variants as a major genetic cause of toxicity during thiopurine therapy,

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The first genetic test to aid in the diagnosis of Fragile X Syndrome

Posted on February 26, 2020 by by

Joseph Gut - thasso Posted in Allelic Variant, Genetic Background, Regulatory Approval, Thasso Post, Theragenomic Medicine No Comments ↓

February 26, 2020 – Fragile X syndrome (FXS) is a genetic disorder characterized by mild-to-moderate intellectual disability.The average IQ in males is under 55, while about two thirds of females are intellectually disabled. Physical features may include a long and narrow face,

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Tapping into the massive potential of African genomes: 54gene

Posted on February 22, 2020 by by

Joseph Gut - thasso Posted in Genetic Background, In The Press, On The Horizon, Thasso Post, Theragenomic Medicine No Comments ↓

February 22, 2020 – Genetic studies rely almost entirely on genomes from people of Caucasian descent. While all around the world, tissue and blood banks have sprung up to catalog human genome’s many mysteries, this was not the case for Africa. Until now,

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Heart disease prediction by traditional risk factors as good as with an exhaustive genetic test

Posted on February 20, 2020 by by

Joseph Gut - thasso Posted in Genetic Background, Genetic Predisposition, Genetic Susceptibility, Personalized Medicine, Personomics, Thasso Post, Theragenomic Medicine No Comments ↓

February 20, 2020 – Traditional cardiovascular risk factors often assessed in an annual physical, such as blood pressure, cholesterol levels, diabetes, and smoking status, may at least be as valuable in predicting who will develop coronary heart disease (CHD) as a sophisticated genetic test that surveys millions of different points in DNA,

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How relates lifetime prevalence of skin cancer to sexual orientation

Posted on February 14, 2020 by by

Joseph Gut - thasso Posted in New Research, Personomics, Thasso Post, Theragenomic Medicine No Comments ↓

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Brain, Body Incongruence in Transgenders: Gene Variants Provide Some Insights

Posted on February 6, 2020 by by

Joseph Gut - thasso Posted in Allelic Variant, Genetic Background, New Research, Personomics, Thasso Post, Theragenomic Medicine No Comments ↓

February 06, 2020 – Some of the first biological evidence of the incongruence transgender individuals experience, because their brain indicates they are one sex and their body another, may have been found in estrogen receptor pathways in the brain of 30 transgender individuals.

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East Asians, Europeans: Genomic Features of Lung Adenocarcinoma Differ

Posted on February 5, 2020 by by

Joseph Gut - thasso Posted in Ethnicity, Genetic Background, Thasso Post, Theragenomic Medicine No Comments ↓

February 05, 2020 – Lung adenocarcinoma is a common cancer and leads to more than one million deaths each year, Lung tumors isolated from adenocarcinoma patients of East Asian ancestry have a less complex genomic architecture than tumors from European patients, a new study has found.

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Soccer Headers Might Be More Risky for APOE4 Genotype Carriers

Posted on February 1, 2020 by by

Joseph Gut - thasso Posted in Allelic Variant, Genetic Background, Genetic Predisposition, Genetic Susceptibility, In The Press, New Research, Thasso Post, Theragenomic Medicine No Comments ↓

February 01, 2020 – Soccer headers might be more risky for APOE4 genotype carriers – this is the headline of a very recent Reuters Health article appearing in Medscape. Thus, soccer players with apolipoprotein E4 (APOE4) genotype may want to limit how many headers they do,

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The diversity of Asian genomes

Posted on January 26, 2020 by by

Joseph Gut - thasso Posted in Allelic Variant, Ethnicity, Genetic Background, Genetic Predisposition, Genetic Susceptibility, New Research, Thasso Post, Theragenomic Medicine, Theragenomics 1 Comment ↓

January 26, 2020 – An effort to map thousends of genomes across Asia has certainly the potential to find novel gene variants affecting disease and responses to drugs, and to reveal the complex origins of Asian populations.

In a pilot study,