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Host factors may influence Covid-19 severity more than viral genetic variation

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May 22, 2020 – Host factors (i.e., disease phenotypes and/or predispositions) instead of viral genetic variation seem to impact more on sickness severity among Covid-19 patients, as indicated by an investigation from China. Scientists in Shanghai analyzed clinical, atomic, and immunological information from in excess of 300 individuals with affirmed Covid-19.

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Abdominal aortic aneurysm: Genetic scoring can identify more men at risk

Posted on by by Posted in Genetic Predisposition, Genetic Susceptibility, New Research, On The Horizon, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

May 07, 2020 – Abdominal aortic aneurysm (AAA) is a localized enlargement of the abdominal aorta such that the diameter is greater than 3 cm or more than 50% larger than normal. AAAs usually cause no symptoms, except during rupture. 

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Besides the now approved remdesivir: Emerging options to treat Covid-19

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May 03, 2020 –  The world is desperate in the search for a treatment or better yet a vaccine in the Covid-19 pandemic. Slowly, there are some options emerging at least for the treatment of seriously ill Covid-19 patients. First of all,  the American Food and Drug Administration just issued an emergency use authorization (EUA) for the investigational antiviral drug remdesivir for the treatment of suspected or laboratory-confirmed COVID-19 in adults and children hospitalized with severe disease.

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Could DNA testing help the most seriously affected Covid-19 patients?

Posted on by by Posted in Allelic Variant, Genetic Background, Genetic Predisposition, New Research, Personomics, Thasso Post, Theragenomic Medicine No Comments ↓

April 28, 2020 – Coronavirus disease 2019 (Covid-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease was first identified in December 2019 in Wuhan, the capital of China’s Hubei province,

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Klotho’s role in some patients with Alzheimer’s disease revealed?

Posted on by by Posted in Allelic Variant, Genetic Background, Genetic Predisposition, New Research, Personomics, Thasso Post, Theragenomic Medicine 1 Comment ↓

April 24, 2020 – The klotho gene is named after the fanciful Greek goddess of destiny Clotho who turns the string of life known to be related with longer life and improved cognizance. In modern biology, allelic variants of the klotho gene in fact have been associated with long life span.

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First therapy for children with debilitating NF-1 approved in the USA

Posted on by by Posted in Genetic Background, New Drug Approval, Pediatrics, Rare Diseases, Thasso Post, Theragenomic Medicine No Comments ↓
April 12, 2020 – The human genetic disease neurofibromatosis type 1 (NF-1) is a complex multi-system disorder caused by the mutation of a gene  (NF1 gene) on chromosome 17 that is responsible for production of a protein called neurofibromin which is needed for normal function in many human cell types.

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Inherited mutation in ELP1 predisposes children to medulloblastoma

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April 03, 2020 – Medulloblastoma is the most common malignant pediatric brain tumor. Medulloblastomas are invasive, rapidly growing tumors that, unlike most brain tumors, spread through the cerebrospinal fluid and frequently metastasize to different locations along the surface of the brain and spinal cord. 

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Covid-19: Be careful with chloroquine and hydroxychloroquine

Posted on by by Posted in Adverse Drug Reaction [ADR], New Safety Information, Regulatory Announcement, Thasso Post, Theragenomic Medicine No Comments ↓

March 25, 2020 – The Covid-19 pandemic keeps the word abreast. Drastic measures have been and are being taken worldwide by governments, hospitals, healthcare  care providers, and retiring homes in attempts to halt the spreading of Covid-19. Recently, there have been publications by Chinese clinical researchers in the Journal Cell Research and the International Journal of Antimicrob Agents indicating that both,

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Large genetic map of psychiatric disorders completed

Posted on by by Posted in Allelic Variant, Genetic Background, Genetic Predisposition, Thasso Post, Theragenomic Medicine 3 Comments ↓

March 15, 2020 –  An international study published in the journal Cell has described 109 genetic variants associated with eight psychiatric disorders such as autism, ADHD, schizophrenia, bipolar disorder, depression, obsessive-compulsive disorder and Tourette syndrome in a total of about 230,000 patients worldwide.  

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Are Asians at higher genetic risk of serious adverse events to common medications?

Posted on by by Posted in Adverse Drug Reaction [ADR], Allelic Variant, Ethnicity, Genetic Predisposition, Personalized Medicine, Thasso Post, Theragenomic Medicine No Comments ↓

March 10, 2020 – A widespread assumption is, the people of Asian descent are more prone to serious, sometimes deadly adverse drug reactions, even when taking rather common medications prescribed for gout through to depression. In the ages of genetics and precision medicine, the question then comes up if Asian people could be at such heightened risk because of underlying particular genetic factors.…

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RSS random genetics

  • Scientists identify gene linked to thinness that may help resist weight gain May 21, 2020
    While others may be dieting and hitting the gym hard to stay in shape, some people stay slim effortlessly no matter what they eat. In a study publishing May 21 in the journal Cell, researchers use a genetic database of more than 47,000 people in Estonia to identify a gene linked to thinness that may […]
  • Tracking the COVID-19 pandemic in Australia using genomics May 21, 2020
    Using genome sequencing to identify genetic mutations in SARS-CoV-2 cases in Victoria, researchers have identified clusters and transmission networks which has helped limit the spread of the virus, painting an important picture of transmission in Victoria.
  • COVID-19 study looks at genetics of healthy people who develop severe illness May 21, 2020
    To help unravel the mysteries of COVID-19, scientists are sequencing the DNA of young, healthy adults and children who develop severe illness despite having no underlying medical problems. The researchers are looking for genetic defects that could put certain individuals at high risk of becoming severely ill from the novel coronavirus.
  • Scientists discover more than 200 genetic factors that cause heart arrhythmia May 21, 2020
    Hundreds of new links have been found between people's DNA and the heart's electrical activity, according to a study of almost 300,000 people led by researchers at Queen Mary University of London and the Broad Institute of MIT and Harvard.
  • Weight loss surgery may alter gene expression in fat tissue May 21, 2020
    Altered gene expression in fat tissue may help explain why individuals who have regained weight after weight loss surgery still experience benefits such as metabolic improvements and a reduced risk of type 2 diabetes. The findings come from a study published in the Journal of Internal Medicine.

RSS random science

  • New studies reveal extent and risks of laughing gas & stimulant abuse among young people May 23, 2020
    In one study, researchers from Turkey reported increasing stimulant use among medical students approaching their final exams, despite the substantial risks to their health. In the second study, researchers from the Netherlands detailed the neurological outcomes associated with recreational use of laughing gas (nitrous oxide), suggesting that, for some individuals, permanent neurological damage can occur.
  • Sleep-wake disturbances can predict recurrent events in stroke survivors May 23, 2020
    The study, conducted in Switzerland, found that having multiple sleep-wake disturbances such as sleep-disordered breathing, extreme long or short sleep duration, insomnia and restless leg syndrome independently and significantly increased the risk of a new cardio-cerebrovascular event in the two years following a stroke.
  • Does MRI have an environmental impact? May 23, 2020
    Researchers from Tokyo Metropolitan University have surveyed the amount of gadolinium found in river water in Tokyo. Gadolinium is contained in contrast agents given to patients undergoing medical magnetic resonance imaging (MRI) scans, and it has been shown in labs to become toxic when exposed to ultraviolet rays. The researchers found significantly elevated levels, particularly […]
  • New native grass species have been discovered on the Iberian Peninsula and Menorca May 22, 2020
    The new species belong to the genus Aira, delicate herbaceous plants, which enjoy their greatest diversity in the Mediterranean Region. One of them, Aira minoricensis is a native species of the siliceous sands of Menorca. The other new species is called Aira hercynica and is widely found in the area of the Iberia Peninsula which […]
  • Combinatorial screening approach opens path to better-quality joint cartilage May 22, 2020
    High-throughput platform identifies complex conditions with biomaterial compositions, and mechanical and chemical stimuli that help stem cells produce more robust cartilage.
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