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Living theragenomics: Dangers of codeine and tramadol medicines in children

April 23, 2017 – This is a Safety Announcement from April 20, 2017, by the American Food & Drug Administration (FDA) to the fact that FDA further restricts use of prescription codeine pain and cough medicines and tramadol pain medicines in children and recommends against their use in breastfeeding women.

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Children: Is there personalized medicine for children too?

April 04, 2017 – Personalized medicine, also referred to as precision medicine, incorporates the individual patient’s characteristics into treatment, rather than relying on population means. Over the past several years, it has become a significant focus for research. Developments in pharmacogenomics, the study of genomic variations that influence response to drugs,

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Is the iPad a medical device?

September 03, 2016 – This morning, I stumbled upon the headline of a posting on mobihealthnews, entitled “Study finds iPads and games as effective as sedatives to calm pre-op anxiety in children” and starting out with saying “The hypnotic trance kids enter when they’re staring at an iPad isn’t just for on-demand quiet time in restaurants or

cars.

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The European Medicines Agency’s Pharmacovigilance Risk Assessment Committee (PRAC) has recently recommended restrictions on the use of codeine-containing medicines for cough and cold in children because of the risk of serious side effects

March 21, 2015 – The European Medicines Agency’s Pharmacovigilance Risk Assessment Committee (PRAChas recently recommended restrictions on the use of codeine-containing medicines for cough and cold in children because of the risk of serious side effects with these medicines,

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FDA Drug Safety Communication: Codeine use in certain children after tonsillectomy and/or adenoidectomy may lead to rare, but life-threatening adverse events or death

September 27, 2014 – A while ago (August 2012),  the American Food and Drug Administration (FDA) was assessing and reporting on the (possibly fatal) risks associated with the use of codeine containing medicines in children who are phenotypically members of the CYP2D6 Ultrametabolizer Patient Subgroup because oaf their CYP2D6 genetic background.

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Boxed Warning Updated: TNF Blockers and Cancer Risks in Children

November 3, 2009 – As we learn from it’s todays announcement, FDA is requiring stronger warnings about an increased risk of lymphoma and other cancers in children and adolescents who are treated with drugs that block tumor necrosis factor. TNF blockers include Infliximab [Remicade], Etanercept [Enbrel], Adalizumab [Humira], Certolizumab [Cimzia],

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Schizophrenia drugs in kids cause weight gain

October 30, 2009 – Schizophrenia drugs, increasingly prescribed to children with bipolar disorder and other conditions, can cause youngsters to experience rapid weight gain, according to a new study. Thus, children and adolescents who take the drugs, known as atypical antipsychotics, gain an average of 10 to 19 pounds in the first few months,

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  • Spinal muscular atrophy (SMA): Newborn screening promises a benefit April 6, 2020
    On behalf of the Federal Joint Committee (G-BA), the Institute for Quality and Efficiency in Health Care (IQWiG) investigated whether it is meaningful to test newborns in Germany for spinal muscular atrophy (SMA) in combination with earlier diagnosis and treatment. The Institute's final report is now available.
  • Alport syndrome severity can be predicted by causative protein genotype April 6, 2020
    A Japanese research team has successfully developed a system to predict the severity of Alport syndrome, a serious hereditary kidney disease that occurs in about 1 out of 5,000 people in the US. Patients with Alport syndrome have abnormalities in the causative protein, type IV collagen, that often lead to chronic renal dysfunction requiring dialysis. […]
  • Research: Hereditary mutation drives aggressive head and neck, lung cancers in Asian population April 6, 2020
    Researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) have uncovered a genetic variant in a gene called MET that is responsible for more aggressive growth of head and neck, and lung cancers. A further probe into the finding revealed therapeutic strategies that could potentially target this […]
  • New insights into the genetic risk factors and disease pathways of multiple sclerosis April 6, 2020
    Multiple sclerosis (MS) is a debilitating disease in which the body's own immune system attacks itself and can, over time, permanently destroy the protective sheaths, or myelin, around nerve fibers in the brain. Myelin insulates nerve cells and facilitates the transmission of messages along them. When the myelin sheath is damaged, the nerves themselves may […]
  • Findings in mice reveal possibilities for fetal drug therapy for deafness April 6, 2020
    New research led by hearing scientists at Oregon Health & Science University suggests an avenue to treat and prevent intractable genetic disorders before birth.
  • Magnetoacoustic waves: Towards a new paradigm of on-chip communication April 6, 2020
    Researchers have observed directly and for the first time magnetoacoustic waves (sound-driven spin waves), which are considered as potential information carriers for novel computation schemes. These waves have been generated and observed on hybrid magnetic/piezoelectric devices. The experiments were designed by a collaboration between the University of Barcelona (UB), the Institute of Materials Science of […]
  • An updated overview of the complex clinical spectrum of tourette syndrome April 6, 2020
    Background: Tourette syndrome is a common nerve development disorder which is characterized by a variety of muscle or vocal movements called 'tics', often involuntary. The disorder is reflectively and quite erroneously associated by many as a just syndrome with tics and the frequent use of undesirable language (swearing). However, Tourette syndrome is a complex neuropsychiatric […]
  • Oil spill: where and when will it reach the beach? Answers to prevent environmental impacts April 6, 2020
    When an accident involving oil spills occurs, forecasting the behaviour of the oil slick and understanding in advance where and when it will reach the coastline is crucial to organize an efficient emergency response that is able to limit environmental and economic repercussions. A study led by CMCC Foundation's researchers, based on the concrete case […]
  • Which healthy lifestyle factors associated with more years free of chronic disease? April 6, 2020
    What combination of healthy lifestyle factors were associated with the most years lived without chronic diseases was the focus of this analysis that included data from more than 100,000 adults who were participants in 12 European studies.
  • Leaving its mark: How frailty impacts the blood April 6, 2020
    Fifteen blood metabolites are key for diagnosing the age-related disorder, frailty, new study finds.
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