Blog Archives

Hot topic: Minimizing the health risks from legalization of Cannabis

March 2, 2017 – This post is about the health risks associated with recreational use of Cannabis and all the aspects that come along with its legalization in at least some states in the United States. The post simply reproduces the article in the New England Journal of Medicine (NEJM) by Beau Kilmer,

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Personomics: The Missing Link from Precision Medicine to Personalized Medicine

October 21, 2017 – Just seen on PubMed:

Ziegelstein RC

 

J Pers Med 2017 Oct;7(4)

PMID: 29035320

Abstract

Clinical practice guidelines have been developed for many common conditions based on data from randomized controlled trials.

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The Clinical and Economic Impact of Inaccurate EGFR Mutation Tests in the Treatment of Metastatic Non-Small Cell Lung Cancer

June 30, 2017 – The below citation from PubMed addresses an vey important issue associated with genetic testing in theragenomic and personalized medicine. It is the question if the genetic test used to stage, classify, or determine treatability of a disease with a given drug is accurate.

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The Trump Administration and the environment: Impact on human health

March 06, 2017 – The following article by Samet et. al. discusses the impact that newly sought after legislation and budgeting cuts by the Trump Administration may have on environmental health. Usually, thasso post does not address politically based issues; in the case of the intention by the Trump Administration to de facto dismantle EPA,

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Epigenetics in Cancer: A Hematological Perspective

October 11, 2016 – Here, you will find an overview article on applied epigenetics and its role when it comes to cancer. This is heavy material to read and therefore most probably geared toward the science-inclined  readers of thasso post and patients in thasso’s patient networks.

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The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

alz-ad-iSeptember 09.  2016 – The pre-clinical animal model and Phase 1b placebo-controlled study in prodromal and mild Alzheimer Disease (AD) patients (n=165), both demonstrate that aducanumab reduced amyloid-beta in the brain and the reduction was dose-dependent. Amyloid-beta plaque is associated with the development of AD and it has for a long time been hypothesized that removing it may slow the clinical decline of people who have AD.

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Adverse clinical outcome associated with mutations in colorectal cancers of African Americans

Colon Cancer in AASeptember 04, 2016 – Case Comprehensive Cancer Center researchers, a research collaboration which includes University Hospitals Seidman Cancer Center and Case Western Reserve University, who last year identified new gene mutations unique to colon cancers in African Americans, have found that tumors with these mutations are highly aggressive and more likely to recur and metastasize.

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Orlistat: Assessment of Adverse Events in Protocols, Clinical Study Reports, and Published Papers

August 30, 2016 – The present article which just appeared in August 2016 issue of  PLOS Medicine illustrates how the inaccurate and biased to say the least the assessment and the reporting of adverse drug reactions by pharmaceutical companies throughout study protocols, investigators brochures,

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Actionable pharmacogenetic markers for prediction and prognosis in breast cancer

Sacco K, Grech G

EPMA J 2015;6(1):15

PMID: 26203310

Abstract

Breast cancer is a heterogeneous disease that necessitates proper patient classification to direct surgery, pharmacotherapy, and radiotherapy. Despite patients within the same subgroup receiving similar pharmacotherapy, substantial variation in clinical outcomes is observed.

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Pharmacogenomics for infectious diseases in sub-Saharan Africa: Successes and opportunities

August 14, 2016 – The PubMed-article below illustrates how pharmacogenetics and/or pharmacogenomics-guided drug therapy (i.e., theragenomic medicine) has its place and impact on patients and healthcare systems in African countries when it comes to large disease burdens such as in HIV/AIDS, Tuberculosis (TB), and malaria.

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  • Concealed cardiomyopathies revealed in cardiac arrest survivors September 30, 2020
    Centenary Institute researchers have discovered that genetic testing can identify "concealed cardiomyopathies" in nearly a quarter of sudden cardiac arrest (SCA) survivors who seem to have a normal heart.
  • Genetic risk of developing obesity is driven by variants that affect the brain September 29, 2020
    Some people are at higher risk of developing obesity because they possess genetic variants that affect how the brain processes sensory information and regulates feeding and behavior. The findings from scientists at the University of Copenhagen support a growing body of evidence that obesity is a disease whose roots are in the brain.
  • Inflammatory gene provides clue to obesity risk September 29, 2020
    A gene that helps to control inflammation increases the risk of obesity and could be turned off in mice to stop weight gain, a study from The University of Queensland has found.
  • Cardiac arrhythmias linked to gene mutations September 29, 2020
    Life-threatening cardiac arrhythmias can be linked to the functional and structural consequences of gene mutations. The study is published in the peer-reviewed journal Bioelectricity.
  • Secret of how fish repair their hearts could help cardiac patients September 29, 2020
    The ability of certain fish to heal damage to their hearts could lead to new treatments for patients who have suffered heart attacks and may also help to unravel how the lifestyle of our parents and grandparents can affect our own heart health.
  • Small molecule targets SARS-CoV-2 RNA for destruction September 30, 2020
    SARS-CoV-2, the virus responsible for COVID-19, has wreaked havoc on health care systems, economies and everyday lives worldwide. Scientists are fighting back with multiple strategies, including vaccines, repurposed drugs developed for other diseases and brand-new therapies. Now, researchers reporting in ACS Central Science have identified small molecules that target a structure within the RNA genome […]
  • Consumers who avoid products with harmful chemicals on the label have lower body burden September 30, 2020
    New research shows that paying close attention to what's in the products you buy can pay off. In a study led by Silent Spring Institute, researchers found that consumers who avoided products containing specific endocrine disruptors had significantly lower levels of the chemicals in their bodies.
  • Cannabinoids associated with negative respiratory health effects in older adults with COPD September 30, 2020
    Cannabinoids, a class of prescription pills that contain synthetically-made chemicals found in marijuana, are associated with a 64 per cent increase in death among older adults with chronic obstructive pulmonary disease (COPD), according to the first published data on the impact of cannabinoids on the respiratory health of individuals with the lung disease.
  • New study reveals how reptiles divided up the spoils in ancient seas September 30, 2020
    While dinosaurs ruled the land in the Mesozoic, the oceans were filled by predators such as crocodiles and giant lizards, but also entirely extinct groups such as ichthyosaurs and plesiosaurs. Now for the first time, researchers at the University of Bristol have modelled the changing ecologies of these great sea dragons.
  • Hackensack Meridian CDI scientists find one-two punch for preclinical cancer models September 30, 2020
    Research findings published Aug. 14, 2020 in the journal Cancer Research suggest that since some cancer treatments can be undermined by epigenetic changes (altered DNA methylation affecting gene expression) in cancer cells before the treatments are even administered, a worthwhile strategy is to administer an epigenetically-acting drug - which can pave the way for more […]
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