Blog Archives

Personomics: The Missing Link from Precision Medicine to Personalized Medicine

October 21, 2017 – Just seen on PubMed:

Ziegelstein RC

 

J Pers Med 2017 Oct;7(4)

PMID: 29035320

Abstract

Clinical practice guidelines have been developed for many common conditions based on data from randomized controlled trials.

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The Clinical and Economic Impact of Inaccurate EGFR Mutation Tests in the Treatment of Metastatic Non-Small Cell Lung Cancer

June 30, 2017 – The below citation from PubMed addresses an vey important issue associated with genetic testing in theragenomic and personalized medicine. It is the question if the genetic test used to stage, classify, or determine treatability of a disease with a given drug is accurate.

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The Trump Administration and the environment: Impact on human health

March 06, 2017 – The following article by Samet et. al. discusses the impact that newly sought after legislation and budgeting cuts by the Trump Administration may have on environmental health. Usually, thasso post does not address politically based issues; in the case of the intention by the Trump Administration to de facto dismantle EPA,

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Hot topic: Minimizing the health risks from legalization of Cannabis

March 2, 2017 – This post is about the health risks associated with recreational use of Cannabis and all the aspects that come along with its legalization in at least some states in the United States. The post simply reproduces the article in the New England Journal of Medicine (NEJM) by Beau Kilmer,

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Epigenetics in Cancer: A Hematological Perspective

October 11, 2016 – Here, you will find an overview article on applied epigenetics and its role when it comes to cancer. This is heavy material to read and therefore most probably geared toward the science-inclined  readers of thasso post and patients in thasso’s patient networks.

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The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

alz-ad-iSeptember 09.  2016 – The pre-clinical animal model and Phase 1b placebo-controlled study in prodromal and mild Alzheimer Disease (AD) patients (n=165), both demonstrate that aducanumab reduced amyloid-beta in the brain and the reduction was dose-dependent. Amyloid-beta plaque is associated with the development of AD and it has for a long time been hypothesized that removing it may slow the clinical decline of people who have AD.

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Adverse clinical outcome associated with mutations in colorectal cancers of African Americans

Colon Cancer in AASeptember 04, 2016 – Case Comprehensive Cancer Center researchers, a research collaboration which includes University Hospitals Seidman Cancer Center and Case Western Reserve University, who last year identified new gene mutations unique to colon cancers in African Americans, have found that tumors with these mutations are highly aggressive and more likely to recur and metastasize.

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Orlistat: Assessment of Adverse Events in Protocols, Clinical Study Reports, and Published Papers

August 30, 2016 – The present article which just appeared in August 2016 issue of  PLOS Medicine illustrates how the inaccurate and biased to say the least the assessment and the reporting of adverse drug reactions by pharmaceutical companies throughout study protocols, investigators brochures,

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Actionable pharmacogenetic markers for prediction and prognosis in breast cancer

Sacco K, Grech G

EPMA J 2015;6(1):15

PMID: 26203310

Abstract

Breast cancer is a heterogeneous disease that necessitates proper patient classification to direct surgery, pharmacotherapy, and radiotherapy. Despite patients within the same subgroup receiving similar pharmacotherapy, substantial variation in clinical outcomes is observed.

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Pharmacogenomics for infectious diseases in sub-Saharan Africa: Successes and opportunities

August 14, 2016 – The PubMed-article below illustrates how pharmacogenetics and/or pharmacogenomics-guided drug therapy (i.e., theragenomic medicine) has its place and impact on patients and healthcare systems in African countries when it comes to large disease burdens such as in HIV/AIDS, Tuberculosis (TB), and malaria.

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  • Give and take: Cancer chromosomes give the game away January 29, 2020
    Dr. Pascal Duijf from QUT's School of Biomedical Sciences and IHBI (Institute of Health and Biomedical Innovation) said the study, published in Nature Communications today, analysed chromosome arm abnormalities in more than 23,000 human tumours and 1000 cancer cell lines.
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    Researchers at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases in Vienna, the University Medical Center of Regensburg, and the National Institute of Hematology and Infectious Diseases and the Semmelweis University in Budapest have studied the response to targeted leukemia therapy […]
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    Researchers at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan and colleagues at Osaka University have found genetic variations in humans related to specific dietary habits. Published in Nature Human Behaviour, the genome-wide association study found 9 gene locations associated with eating and drinking foods like meat, tofu, cheese, tea, and coffee. Among […]
  • Stem cells, CRISPR and gene sequencing technology are basis of new brain cancer model January 29, 2020
    Using genetically engineered human pluripotent stem cells, University of California San Diego School of Medicine researchers created a new type of cancer model to study in vivo how glioblastoma, the most common and aggressive form of brain cancer, develops and changes over time.
  • Treating hemophilia with gene therapy January 29, 2020
    Within the framework of an international study, Lund University and Skåne University Hospital have started treating patients with hemophilia with gene therapy, something that began in January this year. The hope is that the new treatment will significantly simplify everyday life for those with severe hemophilia.
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