Blog Archives

Sweet taste receptor gene TAS1R2 and chocolate powder

January 13, 2019 – Are genetic variations in the sweet taste receptor gene related to chocolate powder and dietary fiber intake in obese children and adolescents? This was the question in a recent study just published in the Journal of Personalized Medicine. On one hand,

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SEMA4D gene variant quadruples obesity risk in individuals of African descent

March 26, 2017 – There is ample evidence that the burden of obesity is not the same across ethnic groups. While diet and lifestyle play a large role in determining body weight, there is also a heritable component. Unfortunately,  most prior studies that have evaluated the role of genes in obesity have looked mostly at people of European or Asian descent,

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If you are obese, can you blame it on your genes?

February 13, 2017 – If you are obese (or plain out fat), can you blame it on your genes? Actually, in very many cases, the answer is a qualified yes. Or a maybe. Under certain circumstances. Researchers are moving towards a better understanding of some of the roots of obesity.

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Association of Psoriasis With the Risk for Type 2 Diabetes Mellitus and Obesity

Lønnberg AS, Skov L, Skytthe A, Kyvik KO, Pedersen OB, Thomsen SF

JAMA Dermatol 2016 Apr;

PMID: 27120802

Abstract

Importance: Psoriasis has been shown to be associated with overweight and type 2 diabetes mellitus. The genetic association is unclear.

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The weight-management drug Liraglutide (Saxenda) has just been approved by the FDA

December 23, 2014 – The U.S. Food and Drug Administration (FDA) just approved Saxenda (liraglutide [rDNA origin] injection) as a treatment option for chronic weight management in addition to a reduced-calorie diet and physical activity.

The drug is approved for use in adults with a body mass index (BMI) of 30 or greater (obesity) or adults with a BMI of 27 or greater (overweight) who have at least one weight-related condition such as hypertension,

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Weight-management drug Contrave approved

September 13, 2014 – The U.S. Food and Drug Administration approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment option for chronic weight management in addition to a reduced-calorie diet and physical activity.

Body Mass Index 30The drug is approved for use in adults with a body mass index (BMI) of 30 or greater (obesity) or adults with a BMI of 27 or greater (overweight) who have at least one weight-related condition such as high blood pressure (hypertension),

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  • Protein AKAP8 suppresses breast cancer metastasis January 27, 2020
    A protein naturally produced in the body has been found to suppress breast cancer metastasis in animal models of human tumors. Researchers led by Baylor College of Medicine also found that high levels of this protein, AKAP8, predicts a better survival for breast cancer patients.
  • The virome of HPV-positive tonsil squamous cell carcinoma and neck metastasis January 27, 2020
    The cover for issue 3 of Oncotarget features Figure 3, "Hierarchical clustering of tonsil squamous cell carcinoma cohorts based on viral signature detection pattern with associated pathological features (perineural invasion (PNI), lymphovascular invasion (LVI), and tumor stage (T stage))," by Carey, et al.
  • Asfotase alfa in hypophosphatasia in childhood/adolescence: Survival benefit for infants January 27, 2020
    Hypophosphatasia (HPP) is a rare congenital metabolic disorder. The frequency of severe courses of disease is estimated at 1:100 000: A deficiency of the enzyme phosphatase results in insufficient mineralization of the bones and thus in severe skeletal malformations. The course of disease varies greatly—the earlier the onset of the disease, the more severe are […]
  • Unrecognized genetic variation in research mouse models can affect immune cells January 27, 2020
    Congenic mouse strains—used for decades in immunology research and assumed to be genetically identical outside of a marker locus—have been found to contain previously unrecognized genetic variation, University of Alabama at Birmingham researchers reported in a study published in the journal Immunity.
  • Genomics experts dispute nine genes linked to congenital heart condition January 27, 2020
    Geneticists and heart specialists around the world had previously reported 17 genes to cause long QT syndrome, a little-known inherited heart condition. However, the Clinical Genome Resource's (ClinGen) expert panel has critically reevaluated the scientific evidence for all 17 reported genes, disputing nine of the genes and revealing only three of the genes to be […]
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