Blog Archives

The Apomediary [Patient Expert] and Personalized Medicine: A Commentary

June 22, 2014 – The individuum (i.e., patient) is the phenotype expert on her/his individualized form of proper disease she/he is suffering from. It is not her/his treating physician, it is not a regulatory person concerned with the safety and efficacy of the medication geared towards treating her/his condition,

Read more ›

Tags: , , , , , , , , , , , , , ,

The diversity of Asian genomes

January 26, 2020 – An effort to map thousends of genomes across Asia has certainly the potential to find novel gene variants affecting disease and responses to drugs, and to reveal the complex origins of Asian populations.

In a pilot study,

Read more ›

Tags: , , , , , , ,

Fingolimod (Gilenya): Warning about rare cases of progressive multifocal leukoencephalopathy (PML)

August 06, 1015 – The American Food and Drug Administration (FDA) has just issued a warning that a case of definite progressive multifocal leukoencephalopathy (PML) and a case of probable PML have been reported in patients taking Fingolimod (Gilenya) for multiple sclerosis (MS).

Read more ›

Tags: , , , , , , , ,

Theragenomic Medicine: Genotyping Might Cut Muscle-Pain Risk with Statin Drugs

November 20, 2014 –  Recent research has addressed the clinically strikingly wide variation among patients in plasma levels of Atorvastatin (Lipitor) and Rosuvastatin (Crestor), even with consistent dosing. This research proposes that the phenomenon is likely related to gene variants that affect the drugs’

Read more ›

Tags: , , , , , ,

Just Wait A Little Longer: Suicide Biomarkers Getting Closer to the Clinic

May 01, 2014 – This is a fantastic article on a very difficult to understand topic, with often very sad outcomes.  The source of the article is Medscape and it reveals how combined efforts from different scientific appoaches may lead to molecular understanding of suicidal behavior,

Read more ›

Tags: , , ,

FDA Drug Safety Communication: Codeine use in certain children after tonsillectomy and/or adenoidectomy may lead to rare, but life-threatening adverse events or death

September 27, 2014 – A while ago (August 2012),  the American Food and Drug Administration (FDA) was assessing and reporting on the (possibly fatal) risks associated with the use of codeine containing medicines in children who are phenotypically members of the CYP2D6 Ultrametabolizer Patient Subgroup because oaf their CYP2D6 genetic background.

Read more ›

Tags: , , , , , ,

Theragenomic Medicine: Palbociclib (Ibrance) approved for postmenopausal women with advanced (metastatic) breast cancer

February 8, 2015 – The American Food and Drug Administration (FDA) has granted accelerated approval to Palbociclib (Ibrance) to treat advanced (metastatic) breast cancer.  The FDA granted Ibrance breakthrough therapy designation because the sponsor demonstrated through preliminary clinical evidence that the drug may offer a substantial improvement over available therapies.

Read more ›

Tags: , , , , , ,

Steps to strengthen cybersecurity of medical devices

October 05, 2014 – To strengthen the safety of medical devices, the U.S. Food and Drug Administration has finalised and released recommendations to manufacturers for managing cybersecurity risks to better protect patient health and information.

Read more ›

Tags: , , , , ,

Valproic Acid [Stavzor]: Newly issued boxed warning for life-threatening liver disease

April 13, 2014 – The American Food and Drug Administration (FDA) has issued a new Boxed Warning for Valproic Acid [Stavzor] and its association with drug induced liver disease (hepatotoxicity, hepatic failure) which may be fatal in some patients. We have taken this information from the March 2014 monthly release to the public of Drug Safety Labeling Changes by MedWatch: The FDA Safety Information and Adverse Event Reporting Program.

Read more ›

Tags: , , , , , , , , ,

Panitumumab (Vectibix) – Rare Cases of Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)

May 27, 2014 – Health Canada informed us today that rare cases of Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) have been reported in patients treated with Panitumumab (Vectibix), and advises as follows:

  • Cases of Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) have been reported rarely (≥1/10,000 patients and <1/1000 patients) in the post-market setting,

Read more ›



thasso: conditions

thasso: newest tweets

thasso: recent comments

View my Flipboard Magazine.

thasso: categories

thasso: archives

thasso: simple chat

You must be a registered user to participate in this chat.

  • Researchers uncover crucial gene for growth of Ewing sarcoma October 23, 2020
    Researchers at the Institut de Recerca Sant Joan de Déu (IRSJD) in collaboration with those at Center for Genomic Regulation (CRG) have discovered that RING1B is a critical gene for the development of Ewing sarcoma, a rare type of developmental cancer that presents in bones and soft tissues. This newly uncovered epigenetic vulnerability in Ewing […]
  • Plant compound reduces cognitive deficits in mouse model of Down syndrome October 23, 2020
    The plant compound apigenin improved the cognitive and memory deficits usually seen in a mouse model of Down syndrome, according to a study by researchers at the National Institutes of Health and other institutions. Apigenin is found in chamomile flowers, parsley, celery, peppermint and citrus fruits. The researchers fed the compound to pregnant mice carrying […]
  • Body's anti-viral defences drive production of a non-functional form of the coronavirus cell receptor October 23, 2020
    Researchers at the Francis Crick Institute have identified a variant of the SARS-CoV-2 cell receptor ACE2, which is driven by antiviral interferon signals. The virus is not able to bind to this variant, dispelling concerns that interferon-based treatments could be inadvertently helping it spread more quickly in the body.
  • Q&A: Getting to the roots of fragile X syndrome October 23, 2020
    The cause of fragile X syndrome (FXS), the most common inherited intellectual disability, is easy to see in the lab. Under electron microscopy, an affected X chromosome exhibits a deformed tip that gives the disorder its name and pinpoints the causative gene malfunction. There's no cure for the disease, whose symptoms include learning deficits and […]
  • How genetic variation gives rise to differences in mathematical ability October 22, 2020
    DNA variation in a gene called ROBO1 is associated with early anatomical differences in a brain region that plays a key role in quantity representation, potentially explaining how genetic variability might shape mathematical performance in children, according to a study published October 22nd in the open-access journal PLOS Biology by Michael Skeide of the Max […]
Top