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FDA approves Siltuximab [Sylvant] for rare Castleman’s disease

April 23, 2014 – The U.S. Food and Drug Administration today approved Sylvant (siltuximab) to treat patients with multicentric Castleman’s disease (MCD), a rare disorder similar to lymphoma (cancer of the lymph nodes).

MCD causes an abnormal overgrowth of immune cells in lymph nodes and related tissues in the body.

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Boxed Warning Updated: TNF Blockers and Cancer Risks in Children

November 3, 2009 – As we learn from it’s todays announcement, FDA is requiring stronger warnings about an increased risk of lymphoma and other cancers in children and adolescents who are treated with drugs that block tumor necrosis factor. TNF blockers include Infliximab [Remicade], Etanercept [Enbrel], Adalizumab [Humira], Certolizumab [Cimzia],

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  • Releasing brakes: Potential new methods for Duchenne muscular dystrophy therapies February 24, 2020
    Researchers identified a group of small molecules that may open the door to developing new therapies for Duchenne muscular dystrophy (DMD), an as-yet-uncured disease that results in devastating muscle weakening and loss. The molecules tested by the team from the Perelman School of Medicine at the University of Pennsylvania eased repression of a specific gene, […]
  • Extra chromosomes in cancers can be good or bad February 24, 2020
    Cancer cells are notorious for their genetic disarray. A tumor cell can contain an abundance of DNA mutations and most have the wrong number of chromosomes. A missing or extra copy of a single chromosome creates an imbalance called aneuploidy, which can skew the activity of hundreds or thousands of genes. As cancer progresses, so […]
  • Researchers show that DNA topological problems may cause lymphoma February 24, 2020
    Researchers from the Spanish National Cancer Research Centre (CNIO), Madrid, and the Andalusian Molecular Biology and Regenerative Medicine Centre (Cabimer), Seville, published a paper in Nature Communications that shows that DNA topological problems may cause endogenous DNA breaks that have a causal relationship with cancer.
  • New DNA test that reveals a child's 'true age' has promise, but ethical pitfalls February 24, 2020
    Epigenetic clocks are a new type of biological test currently capturing the attention of the scientific community, private companies and governmental agencies because of their potential to reveal an individual's "true" age.
  • Mayo researchers recommend all women with breast cancer diagnosis under age 66 be offered genetic testing February 21, 2020
    A study by researchers at Mayo Clinic published this week in the Journal of Clinical Oncology suggests that all women with a breast cancer diagnosis under the age of 66 be offered germline genetic testing to determine if they have a gene mutation known to increase the risk of developing other cancers and cancers among […]
  • Noninvasive, self-adhesive sensor predicted worsening heart failure in veterans February 25, 2020
    A removable, noninvasive, self-adhesive sensor successfully predicted worsening heart failure and the need for hospitalization in veterans several days before hospitalization occurred.The researchers used machine learning to analyze the data provided remotely by the sensor to detect if, and when, a patient's heart failure was worsening.
  • Wearable sensor powered by AI predicts worsening heart failure before hospitalization February 25, 2020
    A new wearable sensor that works in conjunction with artificial intelligence technology could help doctors remotely detect critical changes in heart failure patients days before a health crisis occurs and could prevent hospitalization, according to a study led by University of Utah Health and VA Salt Lake City Health Care System scientists. The researchers say […]
  • Adults don't need tetanus, diphtheria boosters if fully vaccinated as children February 25, 2020
    Adults do not need tetanus or diphtheria booster shots if they've already completed their childhood vaccination series against these rare, but debilitating diseases, research published in the journal Clinical Infectious Diseases indicates. The study found no significant difference in disease rates between countries that require adults to receive tetanus and diphtheria booster shots and those […]
  • By gum! Scientists find new 110-million-year-old treasure February 25, 2020
    A remarkable new treasure has been found by scientists from the University of Portsmouth -- the first fossil plant gum on record. The beautiful, amber-like material has been discovered in 110-million-year-old fossilized leaves.University of Portsmouth Ph.D. student Emily Roberts, made the discovery while examining fossilized leaves of the Welwitschiophyllum plant, found in the Crato Formation, […]
  • New study associates intake of dairy milk with greater risk of breast cancer February 25, 2020
    Intake of dairy milk is associated with a greater risk of breast cancer in women -- up to 80% depending on the amount consumed -- according to a new study conducted by researchers at Loma Linda University Health.
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