théragénomique: biomarqueurs

thasso a préparé pour vous le tableau récapitulatif «biomarqueurs théragénomiques» en fonction de leurs médicaments, de leurs indications et des sections pertinentes de l’étiquette du médicament FDA (pouvant indiquer les groupes de patients concernés). La base de ce produit est la liste des biomarqueurs acceptés publiée par la FDA. Les médicaments sont liés aux étiquettes correspondantes accessibles sur Drugs@FDA.

Veuillez noter que dans ce tableau, l’ingrédient pharmacologique actif (IPA) est répertorié. les noms de marque peuvent varier considérablement, c’est-à-dire que les noms commerciaux de médicaments approuvés en dehors des États-Unis peuvent différer de ceux trouvés aux États-Unis, tout comme les noms de génériques, à la fois à l’intérieur et à l’extérieur des États-Unis. En cas de doute, la recherche de l’API serait une bonne idée.

Veuillez également noter que vous pouvez télécharger une version détaillée du tableau des biomarqueurs pharmacogénomiques dans l’étiquetage des médicaments, avec des sections complètes du texte d’étiquetage relatives à PGX extraites des étiquettes complètes des médicaments.

Malheureusement, il n’y a pas d’équivalent français à ce tableau. Cependant, une version française est en cours de planification.

Dernier mise à jour le mars 15, 2019.

 

DrugTherapeutic Area*Biomarker†Labeling Sections
AbacavirInfectious DiseasesHLA-BBoxed Warning, Dosage and Administration, Contraindications, Warnings and Precautions
Abemaciclib (1)OncologyESR
(Hormone Receptor)
Indications and Usage, Adverse Reactions, Clinical Studies
Abemaciclib (2)OncologyERBB2
(HER2)
Indications and Usage, Adverse Reactions, Clinical Studies
Ado-Trastuzumab EmtansineOncologyERBB2
(HER2)
Indications and Usage, Warnings and Precautions, Adverse Reactions, Clinical Pharmacology, Clinical Studies
AfatinibOncologyEGFRIndications and Usage, Dosage and Administration, Adverse Reactions, Clinical Studies
AlectinibOncologyALKIndications and Usage, Dosage and Administration, Adverse Reactions, Clinical Pharmacology, Clinical Studies
AmifampridineNeurologyNAT2Dosage and Administration, Use in Specific Populations, Clinical Pharmacology
AmitriptylinePsychiatryCYP2D6Precautions
AmoxapinePsychiatryCYP2D6Precautions
AmphetaminePsychiatryCYP2D6Clinical Pharmacology
AnastrozoleOncologyESR, PGR
(Hormone Receptor)
Indications and Usage, Adverse Reactions, Drug Interactions, Clinical Studies
Arformoterol (1)PulmonaryUGT1A1Clinical Pharmacology
Arformoterol (2)PulmonaryCYP2D6Clinical Pharmacology
AripiprazolePsychiatryCYP2D6Dosage and Administration, Use in Specific Populations, Clinical Pharmacology
Aripiprazole LauroxilPsychiatryCYP2D6Dosage and Administration, Use in Specific Populations, Clinical Pharmacology
Arsenic TrioxideOncologyPML-RARAIndications and Usage
Articaine and Epinephrine (1)AnesthesiologyG6PDWarnings and Precautions
Articaine and Epinephrine (2)AnesthesiologyNonspecific

(Congenital Methemoglobinemia)
Warnings and Precautions
Ascorbic Acid, PEG-3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, and Sodium SulfateGastroenterologyG6PDWarnings and Precautions
Atezolizumab (1)OncologyCD274
(PD-L1)
Indications and Usage, Dosage and Administration, Adverse Reactions, Clinical Pharmacology, Clinical Studies
Atezolizumab (2)  OncologyGene Signature

(T-effector)
Clinical Studies
AtomoxetinePsychiatryCYP2D6Dosage and Administration, Warnings and Precautions, Adverse Reactions, Drug Interactions, Use in Specific Populations, Clinical Pharmacology
Avatrombopag (1)HematologyF2


(Prothrombin)
Warnings and Precautions
Avatrombopag (2)HematologyF5
(Factor V Leiden)

Warnings and Precautions
Avatrombopag (3)HematologyPROCWarnings and Precautions
Avatrombopag (4)HematologyPROS1

Warnings and Precautions
Avatrombopag (5)HematologySERPINC1

(Antithrombin III)
Warnings and Precautions
AvelumabOncologyCD274
(PD-L1)
Clinical Studies
Azathioprine (1)RheumatologyTPMTDosage and Administration,  Warnings, Precautions, Drug Interactions, Adverse Reactions, Clinical Pharmacology
Azathioprine (2)RheumatologyNUDT15Dosage and Administration, Warnings, Precautions, Adverse Reactions, Clinical Pharmacology
BelinostatOncologyUGT1A1Dosage and Administration, Clinical Pharmacology
Binimetinib (1)OncologyBRAFIndications and Usage, Dosage and Administration, Warnings and Precautions, Adverse Reactions, Use in Specific Populations, Clinical Studies  
Binimetinib (2)OncologyUGT1A1Clinical Pharmacology
BlinatumomabOncologyBCR-ABL1
(Philadelphia chromosome)
Indications and Usage, Clinical Studies
BoceprevirInfectious DiseasesIFNL3
(IL28B)
Clinical Pharmacology
BosutinibOncologyBCR-ABL1
(Philadelphia chromosome)
Indications and Usage, Adverse Reactions, Use in Specific Populations, Clinical Studies
Brentuximab Vedotin (1)OncologyALKClinical Studies
Brentuximab Vedotin (2)OncologyTNFRSF8

(CD30)
Indications and Usage, Dosage and Administration, Adverse Reactions, Use in Specific Populations, Clinical Studies
BrexpiprazolePsychiatryCYP2D6Dosage and Administration, Use in Specific Populations, Clinical Pharmacology
BrigatinibOncologyALKIndications and Usage, Adverse Reactions, Clinical Studies
BrivaracetamNeurologyCYP2C19Clinical Pharmacology
BusulfanOncologyBCR-ABL1
(Philadelphia chromosome)
Clinical Studies
CabozantinibOncologyRETClinical Studies
CapecitabineOncologyDPYDWarnings and Precautions, Patient Counseling Information
Carbamazepine (1)NeurologyHLA-BBoxed Warning, Warnings, Precautions
Carbamazepine (2)NeurologyHLA-AWarnings
Carglumic AcidInborn Errors of MetabolismNAGSIndications and Usage, Warnings and Precautions, Use in Specific Populations, Clinical Pharmacology, Clinical Studies
CariprazinePsychiatryCYP2D6Clinical Pharmacology
CarisoprodolRheumatologyCYP2C19Use in Specific Populations, Clinical Pharmacology
CarvedilolCardiologyCYP2D6Drug Interactions, Clinical Pharmacology
Ceftriaxone (1)Infectious DiseasesG6PDWarnings
Ceftriaxone (2)Infectious DiseasesNonspecific

(Congenital Methemoglobinemia)
Warnings
CelecoxibRheumatologyCYP2C9Dosage and Administration, Use in Specific Populations, Clinical Pharmacology
CeritinibOncologyALKIndications and Usage, Dosage and Administration, Adverse Reactions, Clinical Studies
Cerliponase AlfaInborn Errors of MetabolismTPP1Indications and Usage, Use in Specific Populations, Clinical Studies
Cetuximab (1)OncologyEGFRIndications and Usage, Dosage and Administration, Warnings and Precautions, Adverse Reactions, Clinical Studies
Cetuximab (2)OncologyRASIndications and Usage, Dosage and Administration, Warnings and Precautions, Adverse Reactions, Clinical Studies
CevimelineDentalCYP2D6Precautions
Chloroprocaine (1)AnesthesiologyG6PDWarnings
Chloroprocaine (2)AnesthesiologyNonspecific

(Congenital Methemoglobinemia)
Warnings
ChloroquineInfectious DiseasesG6PDPrecautions
ChlorpropamideEndocrinologyG6PDPrecautions
CisplatinOncologyTPMTAdverse Reactions
Citalopram (1)PsychiatryCYP2C19Dosage and Administration, Warnings, Clinical Pharmacology
Citalopram (2)PsychiatryCYP2D6Clinical Pharmacology
ClobazamNeurologyCYP2C19Dosage and Administration, Use in Specific Populations, Clinical Pharmacology
ClomipraminePsychiatryCYP2D6Precautions
ClopidogrelCardiologyCYP2C19Boxed Warning, Warnings and Precautions, Clinical Pharmacology
ClozapinePsychiatryCYP2D6Dosage and Administration, Use in Specific Populations, Clinical Pharmacology
CobimetinibOncologyBRAFIndications and Usage, Dosage and Administration, Adverse Reactions, Clinical Studies
CodeineAnesthesiologyCYP2D6Boxed Warning, Warnings and Precautions, Use in Specific Populations, Patient Counseling Information
Crizotinib (1)OncologyALKIndications and Usage, Dosage and Administration, Adverse Reactions, Use in Specific Populations, Clinical Pharmacology, Clinical Studies
Crizotinib (2)OncologyROS1Indications and Usage, Dosage and Administration, Adverse Reactions, Use in Specific Populations, Clinical Studies
Dabrafenib (1)OncologyBRAFIndications and Usage, Dosage and Administration, Warnings and Precautions, Adverse Reactions, Clinical Pharmacology, Clinical Studies, Patient Counseling Information
Dabrafenib (2)OncologyG6PDWarnings and Precautions, Adverse Reactions, Patient Counseling Information
Dabrafenib (3)OncologyRASDosage and Administration, Warnings and Precautions
DaclatasvirInfectious DiseasesIFNL3
(IL28B)
Clinical Studies
DacomitinibOncologyEGFRIndications and Usage, Dosage and Administration, Adverse Reactions, Use in Specific Populations, Clinical Studies
Dapsone (1)DermatologyG6PDWarnings and Precautions, Use in Specific Populations
Dapsone (2)DermatologyNonspecific
(Congenital  Methemoglobinemia)
Warnings and Precautions
Dapsone (3)Infectious DiseasesG6PDPrecautions, Adverse Reactions, Overdosage
DarifenacinUrologyCYP2D6Clinical Pharmacology
Dasabuvir, Ombitasvir, Paritaprevir, and RitonavirInfectious DiseasesIFNL3
(IL28B)
Clinical Studies
DasatinibOncologyBCR-ABL1
(Philadelphia chromosome)
Indications and Usage, Dosage and Administration, Warnings and Precautions, Adverse Reactions, Clinical Studies
Denileukin DiftitoxOncologyIL2RA
(CD25 antigen)
Indications and Usage, Warnings and Precautions, Clinical Studies
DesfluraneAnesthesiologyNonspecific
(Genetic Susceptibility to Malignant Hyperthermia)
Contraindications
DesipraminePsychiatryCYP2D6Precautions
DesvenlafaxinePsychiatryCYP2D6Clinical Pharmacology
DeutetrabenazineNeurologyCYP2D6Dosage and Administration, Warnings and Precautions, Use in Specific Populations, Clinical Pharmacology
DexlansoprazoleGastroenterologyCYP2C19Drug Interactions, Clinical Pharmacology
Dextromethorphan and QuinidineNeurologyCYP2D6Warnings and Precautions, Clinical Pharmacology
DiazepamNeurologyCYP2C19Clinical Pharmacology
DinutuximabOncologyMYCNClinical Studies
DocetaxelOncologyESR, PGR

(Hormone Receptor)
Clinical Studies
DolutegravirInfectious DiseasesUGT1A1Clinical Pharmacology
DonepezilNeurologyCYP2D6Clinical Pharmacology
Doxepin (1)PsychiatryCYP2D6Clinical Pharmacology
Doxepin (2)PsychiatryCYP2C19Clinical Pharmacology
DronabinolGastroenterologyCYP2C9Use in Specific Populations, Clinical Pharmacology
Drospirenone and Ethinyl EstradiolGynecologyCYP2C19Clinical Pharmacology
DuloxetinePsychiatryCYP2D6Drug Interactions
DurvalumabOncologyCD274
(PD-L1)
Clinical Pharmacology, Clinical Studies
DuvelisibOncologyChromosome 17pClinical Studies
EfavirenzInfectious DiseasesCYP2B6Clinical Pharmacology
ElagolixGynecologySLCO1B1Clinical Pharmacology
Elbasvir and GrazoprevirInfectious DiseasesIFNL3
(IL28B)
Clinical Studies
EliglustatInborn Errors of MetabolismCYP2D6Indications and Usage, Dosage and Administration, Contraindications, Warnings and Precautions, Drug Interactions, Use in Specific Populations, Clinical Pharmacology, Clinical Studies
ElosulfaseInborn Errors of MetabolismGALNSIndications and Usage, Warnings and Precautions, Use in Specific Populations, Clinical Pharmacology, Clinical Studies
Eltrombopag (1)HematologyF5
(Factor V Leiden)
Warnings and Precautions
Eltrombopag (2)HematologySERPINC1
(Antithrombin III)
Warnings and Precautions
Emapalumab-lzsgHematologyPRF1, RAB27A, SH2D1A, STXBP2, STX11, UNC13D, XIAP (Hemophagocytic Lymphohistiocytosis)Clinical Studies
EnasidenibOncologyIDH2Indications and Usage, Dosage and Administration, Clinical Pharmacology, Clinical Studies
EncorafenibOncologyBRAFIndications and Usage, Dosage and Administration, Warnings and Precautions, Adverse Reactions, Use in Specific Populations, Clinical Pharmacology, Clinical Studies  
EnfluraneAnesthesiologyNonspecific
(Genetic Susceptibility to Malignant Hyperthermia)
Contraindications
Eribulin (1)OncologyERBB2

(HER2)
Clinical Studies
Eribulin (2)OncologyESR, PGR

(Hormone Receptor)
Clinical Studies
ErlotinibOncologyEGFRIndications and Usage, Dosage and Administration, Adverse Reactions, Clinical Studies
Erythromycin and SulfisoxazoleInfectious DiseasesG6PDPrecautions
Escitalopram (1)PsychiatryCYP2D6Drug Interactions
Escitalopram (2)PsychiatryCYP2C19Adverse Reactions
EsomeprazoleGastroenterologyCYP2C19Drug Interactions, Clinical Pharmacology
EteplirsenNeurologyDMDIndications and Usage, Adverse Reactions, Use in Specific Populations, Clinical Studies
Everolimus (1)OncologyERBB2
(HER2)
Indications and Usage, Dosage and Administration, Warnings and Precautions, Adverse Reactions, Drug Interactions, Use in Specific Populations, Clinical Studies
Everolimus (2)OncologyESR
(Hormone Receptor)
Indications and Usage, Dosage and Administration, Warnings and Precautions, Adverse Reactions, Drug Interactions, Use in Specific Populations, Clinical Studies
ExemestaneOncologyESR, PGR
(Hormone Receptor)
Indications and Usage, Dosage and Administration, Clinical Studies
FesoterodineUrologyCYP2D6Drug Interactions, Clinical Pharmacology
Flibanserin (1)GynecologyCYP2C9Clinical Pharmacology
Flibanserin (2)GynecologyCYP2C19Adverse Reactions, Use in Specific Populations, Clinical Pharmacology
Flibanserin (3)GynecologyCYP2D6Clinical Pharmacology
Fluorouracil (1)DermatologyDPYDContraindications, Warnings
Fluorouracil (2)OncologyDPYDWarnings and Precautions, Patient Counseling Information
FluoxetinePsychiatryCYP2D6Precautions, Clinical Pharmacology
FlurbiprofenRheumatologyCYP2C9Clinical Pharmacology
FlutamideOncologyG6PDWarnings
FluvoxaminePsychiatryCYP2D6Drug Interactions
Formoterol (1)PulmonaryCYP2D6Clinical Pharmacology
Formoterol (2)PulmonaryCYP2C19Clinical Pharmacology
FosphenytoinNeurologyHLA-BWarnings and Precautions
Fulvestrant (1)OncologyERBB2
(HER2)
Indications and Usage, Adverse Reactions, Clinical Studies
Fulvestrant (2)OncologyESR, PGR
(Hormone Receptor)
Indications and Usage, Adverse Reactions, Clinical Pharmacology, Clinical Studies
GalantamineNeurologyCYP2D6Clinical Pharmacology
Gefitinib (1)OncologyEGFRIndications and Usage, Dosage and Administration, Clinical Studies
Gefitinib (2)OncologyCYP2D6Clinical Pharmacology
GilteritinibOncologyFLT3Indications and Usage, Dosage and Administration, Clinical Studies
GlimepirideEndocrinologyG6PDWarnings and Precautions, Adverse Reactions
GlipizideEndocrinologyG6PDPrecautions
GlyburideEndocrinologyG6PDPrecautions
GoserelinOncologyESR, PGR

(Hormone Receptor)
Indications and Usage, Clinical Studies
HydralazineCardiologyNonspecific
(NAT)
Clinical Pharmacology
HydroxychloroquineInfectious DiseasesG6PDPrecautions, Adverse Reactions
Ibrutinib (1)OncologyChromosome 17pIndications and Usage, Clinical Studies
Ibrutinib (2)OncologyChromosome 11qClinical Studies
IloperidonePsychiatryCYP2D6Dosage and Administration, Warnings and Precautions, Drug Interactions, Clinical Pharmacology
Imatinib (1)OncologyKITIndications and Usage, Dosage and Administration, Clinical Studies
Imatinib (2)OncologyBCR-ABL1
(Philadelphia chromosome)
Indications and Usage, Dosage and Administration, Warnings and Precautions, Adverse Reactions, Use in Specific Populations, Clinical Pharmacology, Clinical Studies
Imatinib (3)OncologyPDGFRBIndications and Usage, Dosage and Administration, Clinical Studies
Imatinib (4)OncologyFIP1L1-PDGFRAIndications and Usage, Dosage and Administration, Clinical Studies
ImipraminePsychiatryCYP2D6Precautions
IndacaterolPulmonaryUGT1A1Clinical Pharmacology
InotersenNeurologyTTRAdverse Reactions, Clinical Pharmacology
Inotuzumab OzogamicinOncologyBCR-ABL1
(Philadelphia chromosome)
Clinical Studies
Ipilimumab (1)OncologyHLA-AClinical Studies
Ipilimumab (2)OncologyMicrosatellite Instability, Mismatch RepairIndications and Usage, Adverse Reactions, Use in Specific Populations, Clinical Studies
IrinotecanOncologyUGT1A1Dosage and Administration, Warnings and Precautions, Clinical Pharmacology
IsofluraneAnesthesiologyNonspecific
(Genetic Susceptibility to Malignant Hyperthermia)
Contraindications
Isoniazid, Pyrazinamide, and RifampinInfectious DiseasesNonspecific
(NAT)
Clinical Pharmacology
Isosorbide DinitrateCardiologyCYB5ROverdosage
Isosorbide MononitrateCardiologyCYB5ROverdosage
IvacaftorPulmonaryCFTRIndications and Usage, Adverse Reactions, Use in Specific Populations, Clinical Pharmacology, Clinical Studies
Ivacaftor and LumacaftorPulmonaryCFTRIndications and Usage, Adverse Reactions, Use in Specific Populations, Clinical Studies
Ivacaftor and TezacaftorPulmonaryCFTRIndications and Usage, Adverse Reactions, Use in Specific Populations, Clinical Pharmacology, Clinical Studies
IvosidenibOncologyIDH1Indications and Usage, Dosage and Administration, Clinical Pharmacology, Clinical Studies
Ixabepilone (1)OncologyERBB2

(HER2)
Clinical Studies
Ixabepilone (2)OncologyESR, PGR

(Hormone Receptor)
Clinical Studies
LacosamideNeurologyCYP2C19Clinical Pharmacology
LansoprazoleGastroenterologyCYP2C19Drug Interactions, Clinical Pharmacology
Lapatinib (1)OncologyERBB2
(HER2)
Indications and Usage, Dosage and Administration, Adverse Reactions, Use in Specific Populations, Clinical Studies
Lapatinib (2)OncologyESR, PGR
(Hormone Receptor)
Indications and Usage, Dosage and Administration, Adverse Reactions, Use in Specific Populations, Clinical Studies
Lapatinib (3)OncologyHLA-DQA1, HLA-DRB1Clinical Pharmacology
LarotrectinibOncologyNTRKIndications and Usage, Dosage and Administration, Adverse Reactions, Clinical Studies
Ledipasvir and SofosbuvirInfectious DiseasesIFNL3
(IL28B)
Clinical Studies
LenalidomideHematologyChromosome 5qBoxed Warning, Indications and Usage, Adverse Reactions, Use in Specific Populations, Clinical Studies
LesinuradRheumatologyCYP2C9Drug Interactions, Clinical Pharmacology
LetrozoleOncologyESR, PGR
(Hormone Receptor)
Indications and Usage, Adverse Reactions, Clinical Studies
Lidocaine and Prilocaine (1)AnesthesiologyNonspecific
(Congenital  Methemoglobinemia)
Warnings and Precautions
Lidocaine and Prilocaine (2)AnesthesiologyG6PDWarnings and Precautions, Clinical Pharmacology
Lidocaine and Tetracaine (1)AnesthesiologyG6PDWarnings and Precautions
Lidocaine and Tetracaine (2)AnesthesiologyNonspecific

(Congenital Methemoglobinemia)
Warnings and Precautions
LofexidineAnesthesiologyCYP2D6Use in Specific Populations
Lorlatinib (1)OncologyALKIndications and Usage, Adverse Reactions, Clinical Studies
Lorlatinib (2)OncologyROS1Adverse Reactions
Lusutrombopag (1)HematologyF2

(Prothrombin)
Warnings and Precautions
Lusutrombopag (2)HematologyF5

(Factor V Leiden)
Warnings and Precautions
Lusutrombopag (3)HematologyPROCWarnings and Precautions
Lusutrombopag (4)HematologyPROS1Warnings and Precautions
Lusutrombopag (5)HematologySERPINC1

(Antithrombin III)
Warnings and Precautions
MafenideInfectious DiseasesG6PDWarnings, Adverse Reactions
MeclizineNeurologyCYP2D6Clinical Pharmacology
Mepivacaine (1)AnesthesiologyG6PDWarnings
Mepivacaine (2)AnesthesiologyNonspecific

(Congenital Methemoglobinemia)
Warnings
Mercaptopurine (1)OncologyTPMTDosage and Administration, Warnings and Precautions, Adverse Reactions, Clinical Pharmacology
Mercaptopurine (2)OncologyNUDT15Dosage and Administration, Warnings and Precautions, Clinical Pharmacology
Methylene BlueHematologyG6PDContraindications, Warnings and Precautions
Metoclopramide (1)GastroenterologyCYB5RUse in Specific Populations, Overdosage
Metoclopramide (2)GastroenterologyG6PDUse in Specific Populations, Overdosage
Metoclopramide (3)GastroenterologyCYP2D6Dosage and Administration, Use in Specific Populations, Clinical Pharmacology
MetoprololCardiologyCYP2D6Drug Interactions, Clinical Pharmacology
Midostaurin (1)OncologyFLT3Indications and Usage, Dosage and Administration, Adverse Reactions, Clinical Studies
Midostaurin (2)OncologyNPM1Clinical Studies
Midostaurin (3)OncologyKITClinical Studies
MigalastatInborn Errors of MetabolismGLAIndications and Usage, Dosage and Administration, Clinical Pharmacology, Clinical Studies
MirabegronUrologyCYP2D6Clinical Pharmacology
MivacuriumAnesthesiologyBCHEWarnings, Precautions, Clinical Pharmacology
ModafinilPsychiatryCYP2D6Clinical Pharmacology
Mycophenolic AcidTransplantationHPRT1Warnings and Precautions
Nalidixic AcidInfectious DiseasesG6PDPrecautions, Adverse Reactions
NebivololCardiologyCYP2D6Dosage and Administration, Clinical Pharmacology
NefazodonePsychiatryCYP2D6Precautions
Neratinib (1)OncologyERBB2
(HER2)
Indications and Usage, Adverse Reactions, Clinical Studies
Neratinib (2)OncologyESR, PGR
(Hormone Receptor)
Clinical Studies
Nilotinib (1)OncologyBCR-ABL1
(Philadelphia chromosome)
Indications and Usage, Dosage and Administration, Warnings and Precautions, Adverse Reactions, Use in Specific Populations, Clinical Pharmacology, Clinical Studies
Nilotinib (2)OncologyUGT1A1Clinical Pharmacology
NiraparibOncologyBRCAClinical Studies
NitrofurantoinInfectious DiseasesG6PDWarnings, Adverse Reactions
Nivolumab (1)OncologyBRAFIndications and Usage, Adverse Reactions, Clinical Studies
Nivolumab (2)OncologyCD274
(PD-L1)
Clinical Pharmacology, Clinical Studies
Nivolumab (3)OncologyMicrosatellite Instability, Mismatch RepairIndications and Usage, Clinical Studies
NortriptylinePsychiatryCYP2D6Precautions
NusinersenNeurologySMN2Clinical Pharmacology, Clinical Studies
ObinutuzumabOncologyMS4A1
(CD20 antigen)
Clinical Studies
Olaparib (1)OncologyBRCAIndications and Usage, Dosage and Administration, Warnings and Precautions, Adverse Reactions, Clinical Studies
Olaparib (2)OncologyERBB2

(HER2)
Indications and Usage, Dosage and Administration, Adverse Reactions, Clinical Studies
Olaparib (3)OncologyESR, PGR

(Hormone Receptor)
Indications and Usage, Clinical Studies
OlaratumabOncologyPDGFRAClinical Studies
OmacetaxineOncologyBCR-ABL1
(Philadelphia chromosome)
Clinical Studies
Ombitasvir, Paritaprevir, and RitonavirInfectious DiseasesIFNL3
(IL28B)
Clinical Studies
OmeprazoleGastroenterologyCYP2C19Drug Interactions, Clinical Pharmacology
OndansetronGastroenterologyCYP2D6Clinical Pharmacology
OsimertinibOncologyEGFRIndications and Usage, Dosage and Administration, Adverse Reactions, Clinical Studies
Ospemifene (1)GynecologyCYP2C9Clinical Pharmacology
Ospemifene (2)GynecologyCYP2B6Clinical Pharmacology
OxcarbazepineNeurologyHLA-BWarnings and Precautions
Oxymetazoline and Tetracaine (1)AnesthesiologyG6PDWarnings and Precautions
Oxymetazoline and Tetracaine (2)AnesthesiologyNonspecific

(Congenital Methemoglobinemia)
Warnings and Precautions
Palbociclib (1)OncologyESR
(Hormone Receptor)
Indications and Usage, Adverse Reactions, Clinical Studies
Palbociclib (2)OncologyERBB2
(HER2)
Indications and Usage, Adverse Reactions, Clinical Studies
PalonosetronGastroenterologyCYP2D6Clinical Pharmacology
Panitumumab (1)OncologyEGFRAdverse Reactions, Clinical Pharmacology, Clinical Studies
Panitumumab (2)OncologyRASIndications and Usage, Dosage and Administration, Warnings and Precautions, Adverse Reactions, Clinical Studies
PantoprazoleGastroenterologyCYP2C19Clinical Pharmacology
Parathyroid HormoneInborn Errors of MetabolismCASRIndications and Usage, Clinical Studies
ParoxetinePsychiatryCYP2D6Drug Interactions
PatisiranNeurologyTTRAdverse Reactions,

Clinical Pharmacology, Clinical Studies
Pazopanib (1)OncologyUGT1A1Clinical Pharmacology
Pazopanib (2)OncologyHLA-BClinical Pharmacology
Peginterferon Alfa-2bInfectious DiseasesIFNL3
(IL28B)
Clinical Pharmacology
PegloticaseRheumatologyG6PDBoxed Warning, Contraindications, Warnings and Precautions, Patient Counseling Information
Pembrolizumab (1)OncologyBRAFAdverse Reactions, Clinical Studies
Pembrolizumab (2)OncologyCD274
(PD-L1)
Indications and Usage, Dosage and Administration, Clinical Studies
Pembrolizumab (3)OncologyMicrosatellite Instability, Mismatch RepairIndications and Usage,
Dosage and Administration, Use in Specific Populations, Clinical Studies 
PerphenazinePsychiatryCYP2D6Precautions, Clinical Pharmacology
Pertuzumab (1)OncologyERBB2
(HER2)
Indications and Usage, Warnings and Precautions, Adverse Reactions, Clinical Pharmacology, Clinical Studies
Pertuzumab (2)OncologyESR, PGR
(Hormone Receptor)
Clinical Studies
Phenytoin (1)NeurologyCYP2C9Clinical Pharmacology
Phenytoin (2)NeurologyCYP2C19Clinical Pharmacology
Phenytoin (3)NeurologyHLA-BWarnings
PimozidePsychiatryCYP2D6Dosage and Administration, Precautions
PiroxicamRheumatologyCYP2C9Clinical Pharmacology
PonatinibOncologyBCR-ABL1
(Philadelphia chromosome)
Indications and Usage, Warnings and Precautions, Adverse Reactions, Use in Specific Populations, Clinical Studies
Prasugrel (1)CardiologyCYP2C19Use in Specific Populations, Clinical Pharmacology, Clinical Studies
Prasugrel (2)CardiologyCYP2C9Use in Specific Populations, Clinical Pharmacology, Clinical Studies
Prasugrel (3)CardiologyCYP3A5Use in Specific Populations, Clinical Pharmacology, Clinical Studies
Prasugrel (4)CardiologyCYP2B6Use in Specific Populations, Clinical Pharmacology, Clinical Studies
Primaquine (1)Infectious DiseasesG6PDContraindications, Warnings, Precautions, Adverse Reactions, Overdosage
Primaquine (2) Infectious DiseasesCYB5RPrecautions, Adverse Reactions
ProbenecidRheumatologyG6PDAdverse Reactions
ProcainamideCardiologyNonspecific

(NAT)
Adverse Reactions, Clinical Pharmacology
PropafenoneCardiologyCYP2D6Dosage and Administration, Warnings and Precautions, Drug Interactions, Clinical Pharmacology
PropranololCardiologyCYP2D6Clinical Pharmacology
ProtriptylinePsychiatryCYP2D6Precautions
QuinidineCardiologyCYP2D6Precautions
Quinine Sulfate (1)Infectious DiseasesG6PDContraindications
Quinine Sulfate (2)Infectious DiseasesCYP2D6Drug Interactions
RabeprazoleGastroenterologyCYP2C19Clinical Pharmacology
RaloxifeneOncologyESR

(Hormone Receptor)
Clinical Studies
RaltegravirInfectious DiseasesUGT1A1Clinical Pharmacology
Rasburicase (1)OncologyG6PDBoxed Warning, Contraindications, Warnings and Precautions
Rasburicase (2)OncologyCYB5RBoxed Warning, Contraindications, Warnings and Precautions
Ribociclib (1)OncologyESR, PGR
(Hormone Receptor)
Indications and Usage, Adverse Reactions, Clinical Studies
Ribociclib (2)OncologyERBB2
(HER2)
Indications and Usage, Adverse Reactions, Clinical Studies
RisperidonePsychiatryCYP2D6Drug Interactions, Clinical Pharmacology
RituximabOncologyMS4A1
(CD20 antigen)
Indications and Usage, Dosage and Administration, Adverse Reactions, Use in Specific Populations, Clinical Studies
RivaroxabanCardiologyF5

(Factor V Leiden)
Clinical Studies
Ropivacaine (1)AnesthesiologyG6PDWarnings
Ropivacaine (2)AnesthesiologyNonspecific

(Congenital Methemoglobinemia)
Warnings
RosuvastatinEndocrinologySLCO1B1Clinical Pharmacology
Rucaparib (1)OncologyBRCAIndications and Usage, Dosage and Administration, Adverse Reactions, Use in Specific Populations, Clinical Studies
Rucaparib (2)OncologyCYP2D6Clinical Pharmacology
Rucaparib (3)OncologyCYP1A2Clinical Pharmacology
SevofluraneAnesthesiologyRYR1Warnings
SimeprevirInfectious DiseasesIFNL3
(IL28B)
Clinical Pharmacology, Clinical Studies
Sodium Nitrite (1)ToxicologyG6PDWarnings and Precautions
Sodium Nitrite (2)ToxicologyNonspecific

(Congenital Methemoglobinemia)
Boxed Warning, Warnings and Precautions
Sodium PhenylbutyrateInborn Errors of MetabolismASS1, CPS1, OTC

(Urea Cycle Disorders)
Indications and Usage, Dosage and Administration
SofosbuvirInfectious DiseasesIFNL3
(IL28B)
Clinical Studies
Sofosbuvir and VelpatasvirInfectious DiseasesIFNL3
(IL28B)
Clinical Studies
Sofosbuvir, Velpatasvir, and VoxilaprevirInfectious DiseasesIFNL3
(IL28B)
Clinical Studies
SuccimerHematologyG6PDClinical Pharmacology
SuccinylcholineAnesthesiologyBCHEWarnings, Precautions
SulfadiazineInfectious DiseasesG6PDWarnings
Sulfamethoxazole and Trimethoprim (1)Infectious DiseasesG6PDPrecautions
Sulfamethoxazole and Trimethoprim (2)Infectious DiseasesNonspecific
(NAT)
Precautions
Sulfasalazine (1)GastroenterologyG6PDPrecautions
Sulfasalazine (2)GastroenterologyNonspecific
(NAT)
Clinical Pharmacology
TafenoquineInfectious DiseasesG6PDDosage and Administration, Contraindications, Warnings and Precautions, Use in Specific Populations, Patient Counseling Information
Talazoparib (1)OncologyBRCAIndications and Usage, Dosage and Administration, Adverse Reactions, Clinical Studies
Talazoparib (2)OncologyERBB2

(HER2)
Indications and Usage, Adverse Reactions, Clinical Studies
Tamoxifen (1)OncologyESR, PGR
(Hormone Receptor)
Indications and Usage, Adverse Reactions, Clinical Pharmacology, Clinical Studies
Tamoxifen (2)OncologyF5
(Factor V Leiden)
Warnings and Precautions
Tamoxifen (3)OncologyF2
(Prothrombin)
Warnings and Precautions
Tamoxifen (4)OncologyCYP2D6Clinical Pharmacology
TamsulosinUrologyCYP2D6Warnings and Precautions, Adverse Interactions, Clinical Pharmacology
TelaprevirInfectious DiseasesIFNL3
(IL28B)
Clinical Pharmacology, Clinical Studies
TetrabenazineNeurologyCYP2D6Dosage and Administration, Warnings and Precautions, Use in Specific Populations, Clinical Pharmacology
Thioguanine (1)OncologyTPMTDosage and Administration, Warnings, Precautions, Clinical Pharmacology
Thioguanine (2)OncologyNUDT15Dosage and Administration, Warnings, Precautions, Clinical Pharmacology
Thioridazine PsychiatryCYP2D6Contraindications, Warnings, Precautions
TicagrelorCardiologyCYP2C19Clinical Pharmacology
TolazamideEndocrinologyG6PDPrecautions
TolbutamideEndocrinologyG6PDPrecautions
TolterodineUrologyCYP2D6Warnings and Precautions, Drug Interactions, Clinical Pharmacology
ToremifeneOncologyESR

(Hormone Receptor)
Indications and Usage, Clinical Studies
TramadolAnesthesiologyCYP2D6Boxed Warning, Warnings, Precautions, Use in Specific Populations, Clinical Pharmacology
Trametinib (1)OncologyBRAFIndications and Usage, Dosage and Administration, Adverse Reactions, Clinical Pharmacology, Clinical Studies, Patient Counseling Information
Trametinib (2)OncologyG6PDAdverse Reactions
Trametinib (3)OncologyRASWarnings and Precautions
Trastuzumab (1)OncologyERBB2
(HER2)
Indications and Usage, Dosage and Administration, Clinical Pharmacology, Clinical Studies
Trastuzumab (2)OncologyESR, PGR
(Hormone Receptor)
Clinical Studies
TretinoinOncologyPML-RARAIndications and Usage, Warnings, Clinical Pharmacology
TrimipraminePsychiatryCYP2D6Precautions
UmeclidiniumPulmonaryCYP2D6Clinical Pharmacology
UstekinumabDermatology and GastroenterologyIL12A, IL12B, IL23AWarnings and Precautions
ValbenazineNeurologyCYP2D6Dosage and Administration, Warnings and Precautions, Use in Specific Populations, Clinical Pharmacology
Valproic Acid (1)NeurologyPOLGBoxed Warning, Contraindications, Warnings and Precautions
Valproic Acid (2)NeurologyNonspecific
(Urea Cycle Disorders)
Contraindications, Warnings and Precautions
Vemurafenib (1)OncologyBRAFIndications and Usage, Dosage and Administration, Warnings and Precautions, Adverse Reactions, Use in Specific Populations, Clinical Pharmacology, Clinical Studies, Patient Counseling Information
Vemurafenib (2)OncologyRASWarnings and Precautions, Adverse Reactions
Venetoclax (1)OncologyChromosome 17pIndications and Usage, Clinical Studies
Venetoclax (2)OncologyChromosome 11qClinical Studies
Venetoclax (3)OncologyTP53Clinical Studies
Venetoclax (4)OncologyIDH1Clinical Studies
Venetoclax (5)OncologyIDH2Clinical Studies
Venetoclax (6)OncologyIGHClinical Studies
Venetoclax (7)OncologyNPM1Clinical Studies
VenlafaxinePsychiatryCYP2D6Drug Interactions, Use in Specific Populations, Clinical Pharmacology
VincristineOncologyBCR-ABL1

(Philadelphia chromosome)
Indications and Usage, Adverse Reactions, Clinical Studies
VoriconazoleInfectious DiseasesCYP2C19Clinical Pharmacology
VortioxetinePsychiatryCYP2D6Dosage and Administration, Clinical Pharmacology
Warfarin (1)HematologyCYP2C9Dosage and Administration, Drug Interactions, Clinical Pharmacology
Warfarin (2)HematologyVKORC1Dosage and Administration, Clinical Pharmacology
Warfarin (3)HematologyPROS1Warnings and Precautions
Warfarin (4)HematologyPROCWarnings and Precautions
















 





























































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