théragénomique: étiquettes de médicaments avec informations annotées

thasso fournit les informations actuelles via PharmGKB, qui annote en permanence les étiquettes des médicaments et / ou les monographies de produits contenant des informations pharmacogénétiques (c’est-à-dire les propriétés thérapeutiques) approuvées par la Food and Drug Administration (FDA) des États-Unis, l’Agence européenne des médicaments (EMA), l’Agence des médicaments et des dispositifs médicaux Japon (PMDA) et Santé Canada (Santé Canada) (HCSC). Les annotations PharmGKB fournissent un bref résumé des informations pharmacogénétiques contenues dans l’étiquette, un extrait de l’étiquette et un fichier PDF téléchargeable de l’étiquette en question, avec les informations pharmacogénétiques respectives mises en évidence. Une liste des gènes et des phénotypes trouvés dans l’étiquette est cartographiée dans les en-têtes de section et répertoriée à la fin de chaque annotation. PharmGKB tente également d’interpréter le niveau d’action impliqué dans chaque étiquette avec la balise «PGx Level».

Malheureusement, ni Swissmedic, l’agence suisse des produits thérapeutiques, ni l’Agence nationale de sécurité du médicament et des produits de santé (ANSM) de la France n’ont pas fourni d’informations similaires. Ainsi, pour le moment, la colonne correspondante du tableau ci-dessous ne contient aucune information.

Et aussi, malheureusement, il n’y a pas d’équivalent français à ce tableau. Cependant, une version française est en cours de planification.

Pharmacogically active ingredient	FDA	EMA	PMDA	HCSC
abacavir	Genetic testing recommended	Genetic testing required	Informative PGx	Genetic testing recommended
abiraterone	Informative PGx
acetaminophen	Actionable PGx			Actionable PGx
afatinib	Genetic testing required	Genetic testing required		Genetic testing required
afutuzumab	Informative PGx
aliskiren		Informative PGx
amitriptyline	Actionable PGx
anastrozole	Genetic testing required			Genetic testing required
arformoterol	Informative PGx
aripiprazole	Actionable PGx	Actionable PGx		Actionable PGx
arsenic trioxide	Genetic testing required	Genetic testing required	Genetic testing required	Genetic testing required
atazanavir		Genetic testing recommended
atomoxetine	Actionable PGx		Actionable PGx	Actionable PGx
atorvastatin	Actionable PGx		Actionable PGx	Actionable PGx
axitinib		Informative PGx
azathioprine	Genetic testing recommended		Actionable PGx	Actionable PGx
belimumab	Informative PGx	Informative PGx
boceprevir	Informative PGx	Informative PGx		Informative PGx
bosutinib	Genetic testing required	Genetic testing required		Genetic testing required
brentuximab vedotin	Informative PGx	Genetic testing required
busulfan	Actionable PGx
cabazitaxel		Informative PGx
capecitabine	Actionable PGx	Actionable PGx	Actionable PGx	Actionable PGx
carbamazepine	Genetic testing required		Informative PGx	Genetic testing recommended
carglumic acid	Genetic testing required	Genetic testing required
carisoprodol	Actionable PGx
carvedilol	Actionable PGx			Actionable PGx
celecoxib	Actionable PGx		Informative PGx	Actionable PGx
ceritinib	Genetic testing required
cetuximab	Genetic testing required	Genetic testing required	Genetic testing required	Genetic testing required
cevimeline	Actionable PGx
chloroquine	Actionable PGx
chlorpropamide	Actionable PGx			Actionable PGx
cisplatin	Actionable PGx
citalopram	Actionable PGx			Actionable PGx
clobazam	Actionable PGx
clomifene
clomipramine	Actionable PGx
clopidogrel	Genetic testing recommended	Actionable PGx	Actionable PGx	Actionable PGx
clozapine	Actionable PGx
codeine	Actionable PGx			Actionable PGx
crizotinib	Genetic testing required	Genetic testing required	Genetic testing required	Genetic testing required
dabrafenib	Actionable PGx	Genetic testing required		Genetic testing required
dapsone	Actionable PGx			Actionable PGx
darifenacin	Actionable PGx	Actionable PGx		Actionable PGx
darunavir		Informative PGx
dasatinib	Genetic testing required	Genetic testing required	Genetic testing required	Genetic testing required
denileukin diftitox	Genetic testing required
desflurane				Actionable PGx
desipramine	Actionable PGx
desloratadine		Informative PGx
dexlansoprazole	Actionable PGx			Actionable PGx
dextromethorphan	Genetic testing recommended	Actionable PGx
diazepam	Actionable PGx
divalproex sodium	Genetic testing required			Genetic testing required
doxepin	Actionable PGx
dronedarone		Informative PGx
drospirenone	Informative PGx			Actionable PGx
efavirenz		Actionable PGx		Actionable PGx
eliglustat	Genetic testing required	Genetic testing required
eltrombopag	Actionable PGx	Actionable PGx	Actionable PGx	Actionable PGx
emtricitabine		Actionable PGx
erlotinib	Genetic testing required	Genetic testing required		Genetic testing required
erythromycin	Actionable PGx			Actionable PGx
esomeprazole	Actionable PGx	Informative PGx		Informative PGx
ethinyl estradiol	Informative PGx	Genetic testing required		Actionable PGx
everolimus	Genetic testing required	Actionable PGx		Genetic testing required
exemestane	Genetic testing required			Genetic testing required
fampridine		Informative PGx
fesoterodine	Actionable PGx	Actionable PGx		Actionable PGx
fluorouracil	Actionable PGx		Actionable PGx	Actionable PGx
fluoxetine	Informative PGx
flurbiprofen	Informative PGx
fluvoxamine	Informative PGx
fosamprenavir		Informative PGx
fulvestrant	Genetic testing required	Genetic testing required	Genetic testing required
galantamine	Informative PGx			Informative PGx
gefitinib	Informative PGx	Genetic testing required	Genetic testing required	Genetic testing required
glibenclamide	Actionable PGx			Actionable PGx
glimepiride	Actionable PGx	Actionable PGx		Actionable PGx
glipizide	Actionable PGx
homoharringtonine	Informative PGx
hydralazine	Informative PGx
ibritumomab	Informative PGx	Genetic testing required
ibrutinib	Genetic testing required	Genetic testing required		Genetic testing required
iloperidone	Actionable PGx
imatinib	Genetic testing required	Genetic testing required	Genetic testing required	Genetic testing required
imipramine	Actionable PGx
indacaterol	Informative PGx	Informative PGx	Informative PGx
indinavir		Informative PGx
irinotecan	Actionable PGx		Actionable PGx	Actionable PGx
isoflurane				Actionable PGx
isoniazid	Informative PGx
isosorbide dinitrate	Informative PGx
ivabradine		Informative PGx
ivacaftor	Genetic testing required	Genetic testing required		Genetic testing required
lansoprazole	Informative PGx
lapatinib	Genetic testing required	Genetic testing required	Genetic testing required	Genetic testing required
lenalidomide	Informative PGx	Informative PGx	Informative PGx	Informative PGx
letrozole	Genetic testing required			Genetic testing required
lomitapide	Informative PGx	Genetic testing required		Informative PGx
mafenide	Actionable PGx
maraviroc	Genetic testing required	Genetic testing required		Genetic testing required
mercaptopurine	Genetic testing recommended	Actionable PGx		Actionable PGx
methylene blue	Actionable PGx	Actionable PGx
metoclopramide	Actionable PGx
metoprolol	Informative PGx			Actionable PGx
mipomersen	Informative PGx
modafinil	Actionable PGx
mycophenolic acid	Actionable PGx		Actionable PGx	Actionable PGx
nalidixic acid	Actionable PGx
nefazodone	Informative PGx
nelfinavir	Informative PGx	Informative PGx
nilotinib	Genetic testing required	Genetic testing required		Genetic testing required
nitrofurantoin	Actionable PGx			Actionable PGx
norelgestromin		Genetic testing required		Actionable PGx
norfloxacin	Actionable PGx			Actionable PGx
nortriptyline	Actionable PGx			Actionable PGx
ofatumumab	Informative PGx	Informative PGx
olanzapine	Informative PGx	Informative PGx
omeprazole	Informative PGx			Informative PGx
panitumumab	Genetic testing required	Genetic testing required	Genetic testing required	Genetic testing required
pantoprazole	Actionable PGx
paroxetine	Informative PGx
pazopanib	Actionable PGx	Actionable PGx
peginterferon alfa-2b	Actionable PGx
pegloticase	Actionable PGx	Genetic testing required
perphenazine	Actionable PGx
pertuzumab	Genetic testing required	Genetic testing required		Genetic testing required
phenylacetic acid	Informative PGx
phenytoin	Actionable PGx			Genetic testing recommended
pimozide	Genetic testing required
ponatinib	Actionable PGx	Genetic testing required
posaconazole		Informative PGx
prasugrel	Informative PGx	Informative PGx
pravastatin	Informative PGx
primaquine	Actionable PGx			Actionable PGx
probenecid	Actionable PGx
propafenone	Actionable PGx			Actionable PGx
propranolol	Informative PGx	Informative PGx
protriptyline	Actionable PGx
pyrazinamide	Informative PGx
quinidine	Genetic testing recommended	Actionable PGx
quinine	Actionable PGx			Actionable PGx
rabeprazole	Informative PGx			Actionable PGx
ranolazine		Actionable PGx
rasburicase	Genetic testing required	Actionable PGx	Genetic testing required	Genetic testing recommended
regorafenib	Informative PGx	Informative PGx
rifampin	Informative PGx
risperidone	Informative PGx			Informative PGx
ritonavir		Informative PGx
rituximab	Informative PGx	Genetic testing required
rosuvastatin	Informative PGx			Actionable PGx
ruxolitinib		Informative PGx
sevoflurane				Actionable PGx
sildenafil		Informative PGx
simeprevir	Informative PGx			Informative PGx
sirolimus		Informative PGx
sodium benzoate	Informative PGx
sodium nitrite	Actionable PGx
sodium phenylbutyrate	Informative PGx	Informative PGx		Genetic testing required
sofosbuvir	Informative PGx
succimer	Informative PGx
succinylcholine				Actionable PGx
sulfadiazine	Actionable PGx			Actionable PGx
sulfamethoxazole	Actionable PGx			Actionable PGx
sulfasalazine	Actionable PGx			Actionable PGx
sulfisoxazole	Actionable PGx			Actionable PGx
sunitinib		Informative PGx
tamoxifen	Actionable PGx			Genetic testing required
telaprevir	Actionable PGx	Actionable PGx
telithromycin		Informative PGx
tenofovir		Actionable PGx
terbinafine	Informative PGx
tetrabenazine	Genetic testing required			Actionable PGx
thioguanine	Actionable PGx			Actionable PGx
thioridazine	Actionable PGx
ticagrelor	Informative PGx	Actionable PGx
timolol		Informative PGx
tiotropium	Informative PGx
tipranavir		Informative PGx
tolterodine	Actionable PGx		Informative PGx	Informative PGx
tositumomab	Informative PGx
tramadol	Actionable PGx			Actionable PGx
trametinib	Genetic testing required	Genetic testing required		Genetic testing required
trastuzumab	Genetic testing required	Genetic testing required	Genetic testing required	Genetic testing required
trastuzumab emtansine	Genetic testing required	Genetic testing required		Genetic testing required
tretinoin	Genetic testing required		Informative PGx	Genetic testing required
trimethoprim	Actionable PGx			Actionable PGx
trimipramine	Actionable PGx
valproic acid	Genetic testing required		Actionable PGx	Actionable PGx
vandetanib		Genetic testing recommended
vardenafil		Informative PGx
velaglucerase alfa	Genetic testing required	Genetic testing required		Genetic testing required
vemurafenib	Genetic testing required	Genetic testing required		Genetic testing required
venlafaxine	Informative PGx
vitamin c	Actionable PGx			Actionable PGx
voriconazole	Actionable PGx	Informative PGx		Actionable PGx
vortioxetine	Actionable PGx	Actionable PGx		Actionable PGx
warfarin	Actionable PGx			Actionable PGx
zonisamide		Informative PGx

Legend (how to read);

Genetic testing required: The label states or implies that some sort of gene, protein or chromosomal testing, including genetic testing, functional protein assays, cytogenetic studies, etc., should be conducted before using this drug.
Genetic testing recommended: The label states or implies that some sort of gene, protein or chromosomal testing, including genetic testing, functional protein assays, cytogenetic studies, etc., is recommended before using this drug.
Actionable PGx: The label does not discuss genetic or other testing for gene/protein/chromosomal variants, but does contain information about changes in efficacy, dosage or toxicity due to such variants.
Informative PGx: The label mentions

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théragénomique: étiquettes de médicaments avec informations annotées

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