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Personalisierte Medizin per se schütz nicht vor schwerwiegenden Arzneimittelnebenwirkungen

25. April 2017 – Personalisierte Medizin per se schütz nicht vor schwerwiegenden Arzneimittelnebenwirkungen. Dies ist eine wichtige Erkenntnis für Patienten / Patientinnen welche eine sogenannte personalisierte (gezielte) Therapie erhalten. Die Informationen und Bewerbungen rund um Arzneimittel welche personalisierte und gezielte Therapien erlauben, könnten nämlich leicht den Eindruck erwecken,

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Therapie mit Vemurafenib (Zelboraf): Auftreten von schweren, manchmal fatalen Strahlenschäden

13. Dezember 2015 – Swissmedic hat eben eine Mitteilung in der Form einer sogenannten Health Professional Communication (HPC) zur Potenzierung der Strahlentoxizität in Zusammenhang mit Vemurafenib (Zelboraf)-Therapien veröffentlicht. Danach traten bei einigen Patienten, welche vor, während oder nach einer Behandlung mit Vemurafenib (Zelboraf) eine Bestrahlungstherapie erhalten haben,

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  • MicroRNA exhibit unexpected function in driving cancer February 20, 2020
    Researchers long thought that only one strand of a double-stranded microRNA can silence genes. Though recent evidence has challenged that dogma, it's unclear what the other strand does, and how the two may be involved in cancer. New research from Thomas Jefferson University has revealed that both strands of some microRNA coordinate to act on […]
  • New therapy stops seizures in mouse model of rare childhood epilepsy February 20, 2020
    Seizure disorders in babies are frightening and heartbreaking. A new basic science breakthrough offers hope for a potential treatment for rare developmental and epileptic encephalopathies resulting from a single genetic mutation. The gene in question, called SCN8A, controls a sodium channel that allows neurons to transmit an electric signal. When this gene is mutated, these […]
  • Scientists find many gene 'drivers' of cancer, but warn: Don't ignore 'passengers' February 20, 2020
    A massive analysis of the entire genomes of 2,658 people with 38 different types of cancer has identified mutations in 179 genes and gene regulators as "drivers"—variations in DNA sequences that lead to the development of cancer.
  • A deep dive into cellular aging February 20, 2020
    Scientists at Sanford Burnham Prebys Medical Discovery Institute and Harvard University have discovered that mitochondria trigger senescence, the sleep-like state of aged cells, through communication with the cell's nucleus—and identified an FDA-approved drug that helped suppress the damaging effects of the condition in cells and mice. The discovery, published in Genes & Development, could lead […]
  • New model of C. elegans helps progress study of rare genetic disease February 20, 2020
    The IDIBELL Neurometabolic Diseases group, with international collaboration, has identified a model of chromosome X-linked adrenoleukodystrophy (X-ALD) in C. elegans. X-ALD is a rare disorder of the nervous system with no available treatment.
  • New findings: Pacific marine national monuments do not harm fishing industry February 20, 2020
    The University of Hawaii at Manoa research team analyzed observer records of individual fishing events, logbook summary reports and detailed satellite data on vessel movements.
  • Research team tackles superbug infections with novel therapy February 20, 2020
    Superbug infections kill 35,000 people in the US annually. A team of researchers has found that a treatment known as AB569 kills pseudomonas aeruginosa in humanized cells in mouse models. The treatment does not harm these humanized cells.
  • Risk of coronavirus importation in Africa February 20, 2020
    Egypt, Algeria and Republic of South Africa are the African countries most at risk for coronavirus COVID-19 importation in the continent, due to high air traffic with the contaminated Chinese provinces. But these countries are also among the best equipped on the continent to quickly detect and deal with new cases. In other African countries, […]
  • Researchers say extended antidepressant use creates physical dependence February 20, 2020
    Researchers explain symptoms associated with Antidepressant Discontinuation Syndrome and provide a schedule for tapering various classes of antidepressants. Patients who stop medication without tapering often experience flulike symptoms, insomnia, nausea, imbalance, sensory disturbances often described as electric shocks or 'brain zaps', and hyperarousal.
  • Old carbon reservoirs unlikely to cause massive greenhouse gas release February 20, 2020
    As global temperatures rise, permafrost and methane hydrates -- large reservoirs of ancient carbon -- have the potential to break down, releasing enormous quantities of the potent greenhouse gas methane. But would this methane actually reach the atmosphere? University of Rochester researchers and their collaborators found that even if methane is released from these natural […]
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