Blog Archives

Unerwünschte psychiatrische Wirkungen / Suizidalität nach Anwendung von Vareniclin [Champix]?

In den USA wie auch in anderen Ländern wurde aus der Spontanbeobachtung über Meldungen von suizidalen Gedanken, Suizidversuchen sowie von Suiziden in zeitlichem Zusammenhang mit der Anwendung des Wirkstoffes Vareniclin berichtet. So wurden z.B. gemäss einer Studie der britischen Arzneimittelbehörde MHRA 54 Todesfälle in Grossbritannien in Zusammenhang champixmit dem Medikament gebracht.

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Einheitliche Warnhinweise zum erhöhten Risiko für suizidales Verhalten bei jungen Erwachsenen

Im Bestreben, die betroffenen Patienten angemessen auf die Gefahren von Arzneimitteln und deren unerwünschten Nebenwirkungen aufmerksam zu machen, verpflichtet das BfArM pharmazeutische Unternehmen, welche Arzneimittel zur Behandlung von Depression in jungen Erwachsenen auf dem Markt haben, die Warnhinweise und Vorsichtsmassnahmen in den Fachinformationen bei Anwendung Suizid/Suizidgedanken oder klinische Verschlechterung per 1.

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Eine Hoffnung weniger für übergewichtige Patienten: Sistierung der Zulassung von Rimonabant [Acomplia]

Aufgrund eines Entscheids des Ausschusses für Humanarzneimittel (CHMP) der 
Europäischen Arzneimittelagentur EMA wurde die Zulassung von Rimonabant [Acomplia] in der europäischen 
Union ab 23. Oktober 2008 bis auf weiteres sistiert. In der Folge wurde die Zulassung von Rimonabant [Acomplia] auch in der Schweiz sistiert.  Rimonabant [Acomplia] war in der Schweiz seit März 2007 zugelassen als Zusatztherapie zu einer leicht hypokalorischen Diät und zu einer Bewegungstherapie für die Behandlung von adiposen Patienten (BMI  >

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  • Genetic tests may differ in their interpretation of certain variants July 1, 2020
    (HealthDay)—Different genetic test interpretations have been identified for genetic variants, and some of these can impact patient management, according to a research letter published online June 30 in the Annals of Internal Medicine.
  • How does our brain fold? Study reveals new genetic insights July 1, 2020
    New research is helping unlock the mystery of how the brain folds as a baby develops in the womb—a process critical to healthy brain function.
  • New infectious disease test accurately diagnoses infection in minutes July 1, 2020
    Melbourne researchers have developed a fast, new test for infections and infectious diseases that could transform Australia's ability to provide targeted clinical care and respond to pandemics and biosecurity threats.
  • Next-generation sequencing to provide precision medicine for rare metabolic disorders June 30, 2020
    An international team of scientists from Switzerland Spain, has studied the genetic basis of aromatase deficiency, a rare metabolic disorder that prevents the production of estrogens in humans, according to new research in JCEM (Journal of Clinical Endocrinology and Metabolism). The latest studies on aromatase deficiency in humans come from the group of Amit V. […]
  • New genomic atlas of the developing human brain June 30, 2020
    For the nascent brain of a human embryo to develop into the complex organ that controls human consciousness, a finely tuned sequence of genetic events has to take place; hundreds of genes are activated and deactivated in a precise symphony. Mutations in these genes disrupt the molecular instruments of the symphony and, if they occur […]
  • Understanding molecular mechanisms of air pollution's impact on ILD critical July 1, 2020
    More research must be done to investigate the role of air pollution on the epigenome in patients with interstitial lung diseases (ILDs), in order to develop strategies that minimize the effects of these pollutants, according to a new article published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.
  • Researchers develop computational model to build better capacitors July 1, 2020
    Researchers have developed a computational model that helps users understand how changes in the nanostructure of materials affect their conductivity - with the goal of informing the development of new energy storage devices for a wide range of electronics.
  • Traffic data show drastic changes in Floridians' behavior at onset of the pandemic July 1, 2020
    Using same-day traffic volumes for March 2019 and March 2020 across Florida, researchers examined the relationship of key governmental requests for public isolation and travel limitations. Results show the drastic changes in human behavior during the onset of the pandemic. Traffic volumes by March 22, 2020, dropped by 47.5% compared to that same point in […]
  • A shake-up in cell culturing: Flame sterilization may affect the culture July 1, 2020
    Researchers from the University of Tsukuba have found that flame-sterilizing shake-flasks, to avoid introducing microbial contaminants, considerably increases the carbon dioxide concentration in the flasks. This enhanced carbon dioxide concentration affects the growth of some microbial species, which may affect the quantity of vaccines or other valuable substances produced by the microbes.
  • Lifetime discrimination may increase risk of hypertension among African Americans July 1, 2020
    A study of African Americans in Mississippi shows an association between experiencing discrimination over a lifetime and developing hypertension (also referred to as high blood pressure).African Americans who reported medium and high levels of lifetime discrimination, compared to those who reported low lifetime discrimination, had a higher risk for hypertension.
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