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Diabetes: No end to SGLT2-inhibitor drugs side effects

01 September 2018 – The American Food and Drug Administration (FDA)  is warning that cases of a very rare but serious infection of the genitals and area around the genitals have been reported with the class of type 2 diabetes medicines called sodium-glucose cotransporter-2 (SGLT2) inhibitors.

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Risk of leg and foot amputations under Canagliflozin (Invokana, Invokamet)

May 17, 2017 – Following up on an earlier Drug Safety Communication from May 2016 and based on new data from two large clinical trials, the American Food & Drug Administration (FDA) has concluded that the type 2 diabetes medicines Canagliflozin (Invokana), Canagliflozin/Metformin (Invokamet),  and Canagliflozin/Metformin (Invokamet XR) cause an increased risk of leg and foot amputations.

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SGLT2 Inhibitors and ketoacidosis: Warnings about too much acid in the blood and serious urinary tract infections included in new drug labels

December 5, 2015 – A safety review by the American Food and Drug Administration (FDA) has resulted in the addition of specific warnings to the drug labels of a specific class of type 2 diabetes medicines called sodium-glucose cotransporter-2 (SGLT2) inhibitors about the risks of too much acid in the blood and of serious urinary tract infections.

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Type 2 Diabetes: Risk for bone fracture and decreased bone mineral density under canagliflozin therapy

 September 12, 2015 – Drug Safety Information: The American Food and Drug Administration (FDA)  has just strengthened the warning for the type 2 diabetes medicines containing  canagliflozin as active ingredient, i.e. Invokana and Invokamet, related to the increased risk of bone fractures, and added new information about decreased bone mineral density in afflicted patients.

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  • When macrophages are deprived of oxygen May 24, 2019
    Infected tissue has a low concentration of oxygen. The body's standard immune mechanisms, which rely on oxygen, can then only function to a limited extent. How does the immune system nevertheless manage to control bacteria under such conditions? Researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg and University Hospital Regensburg discovered that fewer metabolites are produced in the citric […]
  • Science Snapshots -- May 2019 May 24, 2019
    Researchers at Berkeley Lab's Molecular Foundry have predicted fascinating new properties of lithium; a powerful combination of experiment and theory has revealed atomic-level details about how silver helps transform carbon dioxide gas into a reusable form; new study reports the first comprehensive, highly coordinated effort to examine the global diversity and biogeography of activated sludge […]
  • Information and language in news impact prejudice against minorities May 23, 2019
    Researchers at the Institute of Psychology show how news about immigrants and language describing immigrants shape prejudice against immigrants and other social minorities, as part of the project 'Immigrants in the Media.' For instance, nouns used for describing the ethnicity of immigrants enhance prejudice against immigrants more than adjectives.
  • Artificial atomic scale materials: Discovering how electrons fatten! May 23, 2019
    A single and isolated electron has a clear electrical charge, magnetic moment and mass, and its free movement can be precisely predicted. Spanish scientists fabricated a nanoscale artificial material manipulating atoms one after the other and discovered that electrons around are very heavier. Heavy electrons are promising particles which endow of new functionalities to novel […]
  • Allogeneic stem cell transplantation in non-Hodgkin lymphoma: benefit remains unclear May 23, 2019
    Meaningful studies are lacking for certain patient groups. Disease-specific registries could help close the data gap.
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