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Tofacitinib (Xeljanz): Dangers of blood clots in the lungs and of death

June 08, 2019 – For some time now, Tofacitinib (Xeljanz) receives intense attention in the media, with regulatory authorities, and patients and treating physicians alike because of serious concerns of increased risk of blood clots in the lungs and increased mortality in patients treated for ulcerative colitis at the 10-mg twice-daily dose of Tofacitinib (Xeljanz).

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With Infliximab (Flixabi), a huge biosimilar medicine has been approved in the European Union (EU)

 June 22, 2016 – The European Medicines Agency (EMA) has approved, as of the end of May 2016, Infliximab (Flixabi). Infliximab (Flixabi) is a monoclonal antibody that has been designed to attach to a protein called tumour necrosis factor-alpha (TNF-alpha) and block its activity.

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  • New candidate cancer genes identified using math models November 15, 2019
    Computational modeling is the use of computers to simulate and study the behavior of complex systems. Computational approaches are widely adopted in the bioimedical sciences and can be used to sift through large volumes of complex data to extract recurrent patterns that may point to a disease's causes and effects.
  • Turning 'junk' DNA into gold November 15, 2019
    Mining the rich uncharted territory of the genome or genetic material of a cancer cell has yielded gold for Princess Margaret scientists: new protein targets for drug development against prostate cancer.
  • Researchers take first step toward genetic test for childhood short-sightedness November 15, 2019
    Researchers from the Universities of Cardiff and Bristol have devised a test that could in future help to identify children at risk of developing a very common eye condition.
  • Researchers link sisters' paralysis to an 'extremely rare' genetic variant November 15, 2019
    Following a nearly 25-year search across three continents, parents of a pair of sisters—who as children slowly became paralyzed from the waist down—finally have a diagnosis, according to researchers at University of Southern California (USC) and Translational Genomics Research Institute (TGen), an affiliate of City of Hope.
  • Genetic variation in individual brain cell types may predict disease risk November 15, 2019
    One might think that the primary cause of most genetically linked diseases comes from mutations in coding DNA—alterations in coding regions of the genome that can lead directly to changes in the expression of particular proteins important for a healthy body. But the majority of human DNA is non-coding DNA—regions of DNA that do not […]
  • Teens with heart disease improve exercise capacity in large clinical trial November 17, 2019
    The largest-ever clinical trial of a medication for pediatric cardiology patients found that an oral drug significantly improved exercise capacity in adolescent patients with severe, congenital single-ventricle heart defects. A study leader says the physiologic benefits represent a milestone in the care of those who have undergone the Fontan procedure, a palliative operation for single-ventricle […]
  • Rare genetic variants predispose to sudden cardiac death November 16, 2019
    By identifying rare DNA variants that substantially increase risk of sudden cardiac death, researchers have laid the foundation for efforts to identify individuals who could benefit from prevention strategies prior to experiencing symptoms.
  • Early diagnosis of pregnancy-associated heart disease linked to better outcomes November 16, 2019
    Women who are diagnosed with peripartum cardiomyopathy (PPCM) during late pregnancy or within a month following delivery are more likely to experience restored cardiac function and improved outcomes compared to those who are diagnosed later in the postpartum period, according to a new study. The findings underscore the need for increased awareness and monitoring of […]
  • Intermittent fasting increases longevity in cardiac catheterization patients November 16, 2019
    In a new study by researchers at the Intermountain Healthcare Heart Institute in Salt Lake City, researchers have found that cardiac catheterization patients who practiced regular intermittent fasting lived longer than patients who don't.
  • New catalysts remove NOx pollutants at lower temperatures November 16, 2019
    Scientists from Tokyo Metropolitan University have developed a low-temperature catalyst for removing NOx gas from industrial exhaust using ammonia. Composed of bulk 'defective' vanadium oxide instead of vanadium oxides supported on titanium oxide like in commercial catalysts, the catalyst works at lower temperatures (< 150 degrees Celsius) with much higher efficiency. The team demonstrated a […]
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