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Tamoxifen: Wechselwirkung mit SSRIs (Serotonin-Wiederaufnahmehemmern)

Posted on March 21, 2010 by by

Joseph Gut - thasso Posted in Arzneimittelinteraktionen, Behördliche Mitteilung, Pharmakogenetik, Thasso Post, Theragenomische Medizin, Unerwünschte Arzneimittel Nebenwirkungen No Comments ↓

21. März 2010 – In einer kanadischen Kohortenstudie wurde gezeigt, dass der Serotonin-Wiederaufnahmehemmer (SSRI) Paroxetin die Wirkung von Tamoxifen in der Hormonbehandlung eines Mammakarzinoms herabsetzen kann. Bei gleichzeitiger Verabreichung von Tamoxifen und Paroxetin ergab sich eine Erhöhung der Brustkrebssterblichkeit.

Sowohl Tamoxifen als auch SSRIs wie Paroxetin werden über das P450-System der Leber metabolisiert.

…

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Tamoxifen: Wechselwirkung mit SSRIs (Serotonin-Wiederaufnahmehemmern)

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