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Denosumab (XGEVA): Risiko für neue primäre maligne Erkrankungen

15. Juni 2018 – Denosumabist ein humaner monoklonaler Antikörper, der im Knochenstoffwechsel die Effekte von Osteoprotegerin (OPG) imitiert. Denosumab ist ein IgG2-anti-RANKL-Antikörper, der mit sehr hoher Affinität an RANKL bindet und so dessen Interaktion mit RANK hemmt.

Der Receptor Activator of Nuclear Factor Kappa B Ligand (RANKL),

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Nierenfunktionsstörungen mit Zoledronsäure [Aclasta]

21. Juni 2010 –  Zoledronsäaure [Aclasta] wird primär zur Behandlung der Osteoporose bei postmenopausalen Frauen und bei Männern eingesetzt. In Übeinstimmung mit Swissmedic informiert Novartis Pharma Ärzte und Patienten folgendermassen:

Nierenfunktionsstörung und Nierenversagen wurden nach der Verabreichung von Zoledronsäure [Aclasta] beobachtet, insbesondere bei Patienten mit vorbestehender renaler Dysfunktion oder mit anderen Risiken,

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  • Genetics may help predict the right blood pressure drug for you June 25, 2019
    Medication can play a huge role in reducing high blood pressure, a leading cause of stroke, heart attack and other serious health problems. Yet given the wide selection of drugs for doctors to choose from, figuring out which drug works best for someone is difficult.
  • First in vivo proof-of-concept in Steinert's myotonic dystrophy June 25, 2019
    Ana Buj Bello's team, a researcher in an Inserm unit at Genethon, the AFM-Telethon laboratory, has made the proof-of-concept of a CRISPR-Cas9 approach in a mouse model of Steinert's myotonic dystrophy, the most common neuromuscular disease in adults. Indeed, thanks to this genome editing approach, the expanded CTG triplet repeat in the DMPK gene, which […]
  • Gene networks reveal transition from healthy to failing heart June 24, 2019
    Scientists investigating heart failure have been limited to studying diseased heart tissue in the lab—understandably, as people don't tend to pluck out a healthy heart for the sake of research. But now, scientists with access to unusable, yet still healthy, donor hearts have been able to investigate the genomic pillars behind the transition from healthy […]
  • Microbiome links diet to health June 24, 2019
    The composition of the human microbiome, a complex ecosystem of microorganisms, plays a crucial role in lifelong health. Little is known, however, about the detailed molecular mechanisms linking health status to the microbiome of the gut, for example.
  • Researchers find new mutation in the leptin gene June 21, 2019
    The global obesity epidemic is so far-reaching it now has an overarching name: globesity. Texas Biomed Staff Scientist Raul Bastarrachea, M.D., is part of a team that discovered a new mutation in the gene that regulates the key hormone suppressing hunger called leptin. This new mutation could help researchers understand why people develop excess of […]