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Ein Wort zu Valsartan, weiteren Sartanen, und deren Verunreinigungen

3. Februar 2019 – Blutdrucksenkende Arzneimittel welche die Wirkstoffe Valsartan, Candesartan, Irbesartan, Losartan, oder Olmesartan enthalten, sind in den vergangenen Monaten zunehmend in die Kritik geraten, da in verschiedensten Chargen dieser Arzneimittel nitrosaminhaltige Verunreinigungen wie N-Nitrosodimethylamin (NDMA) und N-Nitrosodiethylamin (NDEA), die von der WHO als wahrscheinliche menschliche Karzinogene eingestuft werden,

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Auch in der Schweiz: Valsartan ohne Ende

04. Dezember 2018 – Im Verlaufe dieses Sommers wurde bekannt, dass in der Europäischen Union (EU), in den USA, in Kanada, und anderen Ländern in Arzneimitteln, welche zur Therapie der Hypertonie (hohem Blutdruck) eingesetzt werden, und welche den Wirkstoff Valsartan enthalten, aus der Synthese des Valsartans stammende Verunreinigungen mit dem beim Menschen krebserregenden N-Nitrosodimethylamin (NDMA) sowie,

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  • Researchers uncover crucial gene for growth of Ewing sarcoma October 23, 2020
    Researchers at the Institut de Recerca Sant Joan de Déu (IRSJD) in collaboration with those at Center for Genomic Regulation (CRG) have discovered that RING1B is a critical gene for the development of Ewing sarcoma, a rare type of developmental cancer that presents in bones and soft tissues. This newly uncovered epigenetic vulnerability in Ewing […]
  • Plant compound reduces cognitive deficits in mouse model of Down syndrome October 23, 2020
    The plant compound apigenin improved the cognitive and memory deficits usually seen in a mouse model of Down syndrome, according to a study by researchers at the National Institutes of Health and other institutions. Apigenin is found in chamomile flowers, parsley, celery, peppermint and citrus fruits. The researchers fed the compound to pregnant mice carrying […]
  • Body's anti-viral defences drive production of a non-functional form of the coronavirus cell receptor October 23, 2020
    Researchers at the Francis Crick Institute have identified a variant of the SARS-CoV-2 cell receptor ACE2, which is driven by antiviral interferon signals. The virus is not able to bind to this variant, dispelling concerns that interferon-based treatments could be inadvertently helping it spread more quickly in the body.
  • Q&A: Getting to the roots of fragile X syndrome October 23, 2020
    The cause of fragile X syndrome (FXS), the most common inherited intellectual disability, is easy to see in the lab. Under electron microscopy, an affected X chromosome exhibits a deformed tip that gives the disorder its name and pinpoints the causative gene malfunction. There's no cure for the disease, whose symptoms include learning deficits and […]
  • How genetic variation gives rise to differences in mathematical ability October 22, 2020
    DNA variation in a gene called ROBO1 is associated with early anatomical differences in a brain region that plays a key role in quantity representation, potentially explaining how genetic variability might shape mathematical performance in children, according to a study published October 22nd in the open-access journal PLOS Biology by Michael Skeide of the Max […]