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Progressive Multifokale Leukoenzephalopathie (PML): Seltene Fälle nach Behandlung von MS-Patienten mit Fingolimod (Gilenya)

11 Juni 2016 – In Abstimmung mit Swissmedic, dem Schweizerischen Heilmittelinstitut, hat Novartis Pharma über das Auftreten in der Vergangenheit  von vereinzelten Fälle von progressiver multifokaler Leukoenzephalopathie (PML) bei Patienten mit schubförmig remittierend verlaufender Multipler Sklerose (MS) nach Behandlung mit Fingolimod (Gilenya) informiert.

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Natalizumab (Tysabri)’s Risiko für PML


20. September 2016 – Swissmedic, das Schweizer Heilmittelinstitut, kommuniziert in der Form einer sog. Health Professional Communication (HPC) aktualisierte Massnahmen um dem Risiko von progressiv multifokaler Leukoencephalopathie (PML) unter Therapie mit Natalizumab (Tysabri) entgegenzuwirken.

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  • Concealed cardiomyopathies revealed in cardiac arrest survivors September 30, 2020
    Centenary Institute researchers have discovered that genetic testing can identify "concealed cardiomyopathies" in nearly a quarter of sudden cardiac arrest (SCA) survivors who seem to have a normal heart.
  • Genetic risk of developing obesity is driven by variants that affect the brain September 29, 2020
    Some people are at higher risk of developing obesity because they possess genetic variants that affect how the brain processes sensory information and regulates feeding and behavior. The findings from scientists at the University of Copenhagen support a growing body of evidence that obesity is a disease whose roots are in the brain.
  • Inflammatory gene provides clue to obesity risk September 29, 2020
    A gene that helps to control inflammation increases the risk of obesity and could be turned off in mice to stop weight gain, a study from The University of Queensland has found.
  • Cardiac arrhythmias linked to gene mutations September 29, 2020
    Life-threatening cardiac arrhythmias can be linked to the functional and structural consequences of gene mutations. The study is published in the peer-reviewed journal Bioelectricity.
  • Secret of how fish repair their hearts could help cardiac patients September 29, 2020
    The ability of certain fish to heal damage to their hearts could lead to new treatments for patients who have suffered heart attacks and may also help to unravel how the lifestyle of our parents and grandparents can affect our own heart health.
  • Small molecule targets SARS-CoV-2 RNA for destruction September 30, 2020
    SARS-CoV-2, the virus responsible for COVID-19, has wreaked havoc on health care systems, economies and everyday lives worldwide. Scientists are fighting back with multiple strategies, including vaccines, repurposed drugs developed for other diseases and brand-new therapies. Now, researchers reporting in ACS Central Science have identified small molecules that target a structure within the RNA genome […]
  • Consumers who avoid products with harmful chemicals on the label have lower body burden September 30, 2020
    New research shows that paying close attention to what's in the products you buy can pay off. In a study led by Silent Spring Institute, researchers found that consumers who avoided products containing specific endocrine disruptors had significantly lower levels of the chemicals in their bodies.
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    Cannabinoids, a class of prescription pills that contain synthetically-made chemicals found in marijuana, are associated with a 64 per cent increase in death among older adults with chronic obstructive pulmonary disease (COPD), according to the first published data on the impact of cannabinoids on the respiratory health of individuals with the lung disease.
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    While dinosaurs ruled the land in the Mesozoic, the oceans were filled by predators such as crocodiles and giant lizards, but also entirely extinct groups such as ichthyosaurs and plesiosaurs. Now for the first time, researchers at the University of Bristol have modelled the changing ecologies of these great sea dragons.
  • Hackensack Meridian CDI scientists find one-two punch for preclinical cancer models September 30, 2020
    Research findings published Aug. 14, 2020 in the journal Cancer Research suggest that since some cancer treatments can be undermined by epigenetic changes (altered DNA methylation affecting gene expression) in cancer cells before the treatments are even administered, a worthwhile strategy is to administer an epigenetically-acting drug - which can pave the way for more […]