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Tofacitinib (Xeljanz): Gewisse Arzneimittel haben es in sich

23. März 2020 – Tofacitinib (unter dem Handelsnamen Xeljanz auf dem Markt) ist ein Wirkstoff aus der Gruppe der JAK-Hemmstoffe. Tofacitinib blockiert die Januskinase JAK1 und JAK3 selektiv und irreversibel. Dadurch sind diese nicht mehr in der Lage, durch Zytokine verursachte Aktivierungsvorgänge wie z.B.

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Drospirenon-haltige Kontrazeptiva: Risiko von Venenthrombosen und Lungenembolien mit den Produkten Yasmin, Yasminelle, und Yaz.

25. März 2010 – Einer heutigen Mitteilung können wir entnehmen, dass das Schweizerische Heilmittelinstitut (Swissmedic) das Überprüfungsverfahren der Drospirenon-haltigen Kontrazeptiva abgeschlossen hat.

Die Fach- und Patienteninformation der kombinierten oralen Kontrazeptiva (“Antibaby-Pillen”) Yasmin®, Yasminelle®, und Yaz®,

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  • Genetic determinants of fertility and ongoing natural selection in humans October 29, 2020
    An international team of researchers who identified genetic variants associated with reproductive success say their findings could highlight mechanisms underlying fertility and infertility. In addition, their analyses detected genetic alleles under present-day selection, providing an insight into the nature of ongoing natural selection in humans. Iain Mathieson, Ph.D., a population geneticist at the University of […]
  • Cancer-fighting gene restrains 'jumping genes' October 29, 2020
    About half of all tumors have mutations of the gene p53, normally responsible for warding off cancer. Now, UT Southwestern scientists have discovered a new role for p53 in its fight against tumors: preventing retrotransposons, or "jumping genes," from hopping around the human genome. In cells with missing or mutated p53, the team found, retrotransposons […]
  • Genomic study reveals role for hypothalamus in inflammatory bowel disease October 29, 2020
    Using sophisticated 3-D genomic mapping and integrating with public data resulting from genome-wide association studies (GWAS), researchers at Children's Hospital of Philadelphia (CHOP) have found significant genetic correlations between inflammatory bowel disease (IBD) and stress and depression. The researchers went on to implicate new genes involved in IBD risk that are enriched in both derived […]
  • Study identifies pitfall for correcting mutations in human embryos with CRISPR October 29, 2020
    In a paper published today in the journal Cell, scientists describe unexpected, undesirable outcomes after editing genes in human embryos with CRISPR, a genomic editing system.
  • Spread of a novel SARS-CoV-2 variant across Europe in summer 2020 October 29, 2020
    Researchers from Basel and Spain have identified a novel SARS-CoV-2 variant that has spread widely across Europe in recent months, according to an un-peer-reviewed preprint released this week. While there is no evidence of this variant being more dangerous, its spread may give insights into the efficacy of travel policies adopted by European countries during […]
  • Researchers take a stand on algorithm design for job centers: Landing a job isn't always the right goal October 29, 2020
    Algorithms that assess the risk of citizens becoming unemployed are currently being tested in a number of Danish municipalities. But according to a new study from the University of Copenhagen, gaining employment is not the only relevant goal for those out of work -- nor should it be for an algorithm.
  • Eating less suppresses liver cancer due to fatty liver October 29, 2020
    Liver cancer from too much fat accumulation in the liver has been increasing in many countries including Japan. In order to change this unfortunate state of affairs, it is important to improve the prognosis of non-alcoholic fatty liver disease. Fatty liver is often improved through eating less, getting more exercise, and reducing body weight. The […]
  • Shining a (UV) light on the glow-in-the-dark platypus October 29, 2020
    The fur of the platypus - an Australian species threatened with extinction - glows green under ultraviolet light, a new study finds. This is the first observation of biofluorescence in an egg-laying mammal (monotreme), suggesting this extraordinary trait may not be as rare as previously thought.
  • COVID-19 and obesity: Top abstracts at ObesityWeek® Interactive October 29, 2020
    Innovative scientific research results on Coronavirus disease (COVID-19) and its impact on obesity will be presented through oral and poster abstracts at the 38th Annual Meeting of The Obesity Society (TOS) at ObesityWeek® Interactive. This online event will take place Nov. 2-6, 2020 at www.obesityweek.org. On-Demand materials and other elements of the interactive conference will […]
  • Resistance and challenges to Green Deals should not be underestimated October 29, 2020
    A Perspective by the EASAC Environment Steering Panel
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