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Home › Posts tagged Immune-Related Adverse Drug Reactions (irADRs)

Tag: Immune-Related Adverse Drug Reactions (irADRs)

Cancer therapies: Immune checkpoint inhibitors may kill you

By Joseph Gut - thasso Posted on October 21, 2018 Posted in Adverse Drug Reaction [ADR], New Research, New Safety Information, Thasso Post, Theragenomic Medicine No Comments Tagged with Autoimmunity, CTLA-4 Gene, Fatal Adverse Drug Reaction (FADR), Fatal Colitis, Fatal Hepatitis, Fatal Myocarditis, Fatal Neurological Events, Fatal Pneumonitis, French National Alliance for Life and Health Sciences (AVIESAN), Immune Checkpoint Inhibitors (ICI's), Immune-Related Adverse Drug Reactions (irADRs), Ipilimumab [Yervoy], Nivolumab (Opdivo), Pembrolizumab [Keytruda], Programmed Cell Death–1/Ligand-1 (PD-1/PD-L1), Remove term: Fatal Adverse Drug Reaction (FADR) Fatal Adverse Drug Reaction (fADR), Uppsala Monitoring Center (UMC), VigiBase, World Health Organization (WHO)

Cancer therapies: Immune checkpoint inhibitors may kill you

October 21, 2018 – In a study published online September 13 in JAMA Oncology, the authors just reminded us of the fact that besides all hype about immune checkpoint inhibitors (ICIs) in the cancer therapy field, they can be associated with …

Cancer therapies: Immune checkpoint inhibitors may kill you Read more »

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FDA press releases

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FDA MedWatch

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EMA Press releases

Comirnaty COVID-19 vaccine: EMA recommends approval for children aged 5 to 11, CHMP, 25/11/2021 November 25, 2021
A vision for use of real-world evidence in EU medicines regulation , , 24/11/2021 November 24, 2021
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2011-2020: More than 40% decrease in sales of antimicrobials for use in animals, CVMP, 23/11/2021 November 23, 2021
EMA evaluating data on booster dose of COVID-19 Vaccine Janssen, CHMP, 22/11/2021 November 22, 2021

random genetics

Study finds relationship between immune pathway response to influenza and genetic ancestry November 25, 2021
New research at the University of Chicago has found differences in immune pathway activation to influenza infection between individuals of European and African genetic ancestry. Many of the genes that were associated with these differences in the immune response to the flu are also enriched among genes that correlate with COVID-19 disease severity. The study […]
Scientists discover biological mechanisms caused by deficits in high-risk autism gene November 24, 2021
Scientists at the University of North Carolina at Chapel Hill School of Medicine and colleagues have demonstrated that rare variants in the ANK2 gene, consistently found in individuals with autism spectrum disorder (ASD), can alter architecture and organization of neurons, potentially contributing to autism and neurodevelopmental comorbidities.
Immunosuppressants linked to severe reactions in people with common genetic profile November 23, 2021
A Stanford Medicine-led research team has identified a common genetic profile that predicts severe, potentially fatal reactions to four powerful immune-suppressing drugs. The genetic profile is found in about 20% of the general population.
Vaping—not prior smoking—is associated with changes in gene regulation linked to disease November 23, 2021
Since they hit the market, e-cigarettes have been touted as a safe alternative to tobacco cigarettes for adult smokers. When research began to suggest otherwise, many questioned whether smoking was still to blame for adverse effects, since most vapers are either "dual users" who also smoke cigarettes or have a prior history of smoking.
Stress is a health hazard, but a supportive circle of friends can help undo the damaging effects on your DNA November 22, 2021
Stress affects up to 90% of people, and we know it harms our mental and physical well-being.

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