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Individuen dunkler Hautfarbe mit natürlichen blonden Haaren – In der Genetik ist alles möglich

8. August 2019 – Blondes Haar ist ein eher seltener menschlicher Phänotyp, der fast ausschließlich in Europa und Ozeanien vorkommt. Die menschliche Pigmentierung variiert innerhalb und zwischen den Populationen erheblich und hängt sowohl von der Exposition gegenüber ultravioletter Strahlung (UV) als auch von der Art und Menge des in Melanozyten und Keratinozyten produzierten Melanins ab.

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Tamoxifen: Wechselwirkung mit CYP2D6-Inhibitoren

14. November 2010 –  Einer kürzlichen Mitteilung des BfArM entnehmen wir, dass die gleichzeitige Anwendung von Tamoxifen und starken Inhibitoren des Enzyms Cytochrom P450 2D6 (CYP2D6) möglichst vermieden werden sollte, da ansonsten eine reduzierte Wirksamkeit von Tamoxifen nicht ausgeschlossen werden kann.

Auf Europäischer (EU)-Ebene wurde die potentielle Wechselwirkung von Tamoxifen mit Inhibitoren des Enzyms CYP2D6 und der potentielle Effekt von CYP2D6 Genvarianten auf das klinische Ansprechen von Brustkrebspatientinnen auf die Tamoxifentherapie wissenschaftlich untersucht und diskutiert.

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  • Researchers find genetic links to child obesity across diverse ethnic groups August 22, 2019
    An international team of researchers who analyzed data across multiple ethnicities has produced the largest genetic study to date associated with common childhood obesity. The Early Growth Genetics (EGG) Consortium discovered a robust new signal, fine-mapped previously reported genetic variants, and added to evidence that genetic influences on obesity operate across the lifespan.
  • Researchers develop model to personalize radiation treatment August 22, 2019
    A personalized approach to cancer treatment has become more common over the last several decades, with numerous targeted drugs approved to treat particular tumor types with specific mutations or patterns. However, this same personalized strategy has not translated to radiation therapy, and a one-size-fits-all approach for most patients is still common practice. Moffitt Cancer Center […]
  • How our genes and environment influence BMI and height August 22, 2019
    Environmental conditions influence our body mass index (BMI) by increasing or decreasing the effect of inherited genetic variations, University of Queensland researchers have discovered.
  • Genetic testing and family tree research are revealing painful family secrets, research says August 22, 2019
    Genealogical research and genetic testing are revealing skeletons in family closets and causing rifts among members, a new study shows.
  • Researchers use single-cell sequencing to get a better look at human embryo implantation August 22, 2019
    A team of researchers affiliated with multiple institutions in China has used single-cell sequencing to learn more about the human embryo during implantation in the uterus. In their paper published in the journal Nature, the group describes sequencing thousands of human embryo cells from before, during and after implantation, and what they learned from it.
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