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Progressive Multifokale Leukoenzephalopathie (PML): Seltene Fälle nach Behandlung von MS-Patienten mit Fingolimod (Gilenya)

11 Juni 2016 – In Abstimmung mit Swissmedic, dem Schweizerischen Heilmittelinstitut, hat Novartis Pharma über das Auftreten in der Vergangenheit  von vereinzelten Fälle von progressiver multifokaler Leukoenzephalopathie (PML) bei Patienten mit schubförmig remittierend verlaufender Multipler Sklerose (MS) nach Behandlung mit Fingolimod (Gilenya) informiert.

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BfArM: Strengere kardiovaskuläre Überwachung zu Beginn der Therapie mit Fingolimod [Gilenya] bei Patienten mit schubförmig-remittierend verlaufender Multipler Sklerose

27. Januar 2012 – Das BfArM hat heute mitgeteilt, dass ein “Rote Hand Brief” betreffend Fingolimod [Gilenya] mit untenstehendem Wortlaut von der Firma Novartis Pharma versandt wurde.

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Novartis möchte Sie über wichtige zusätzliche Empfehlungen zu mit Fingolimod [Gilenya] informieren. Diese betreffen eine intensivere Überwachung der kardiovaskulären Funktionen innerhalb der ersten 6 Stunden nach Behandlungsbeginn mit Fingolimod [Gilenya],

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  • Study explores cognitive function in people with mental illness January 22, 2020
    A study funded by the Veterans Administration and directed by researchers at the University of Miami Miller School of Medicine has shown few differences in the profiles of genes that influence cognition between people with schizophrenia, bipolar disorder and the general population. This surprising finding could provide new insights into therapies designed to improve cognition. […]
  • Hope for patients with a rare genetic condition linked to severe infections January 22, 2020
    A team of researchers at CHU Sainte-Justine and Université de Montréal has shed light on the mechanisms that underlie a rare genetic condition by creating the first cellular model of the disease. The study's findings were published today in the Journal of Allergy and Clinical Immunology.
  • Avatar worms help to identify factors that modify genetic diseases January 21, 2020
    Often, patients from the same family and carriers of the same genetic mutation, develop a disease differently. This disparity may be due to the existence of mutations in other secondary genes, which influence the onset and progression of the disease caused by the main mutation. As an example, members of a family who are carriers […]
  • Algorithm turns cancer gene discovery on its head January 21, 2020
    A method for finding genes that spur tumor growth takes advantage of machine learning algorithms to sift through reams of molecular data collected from studies of cancer cell lines, mouse models and human patients.
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    Scientists at UCL have shown a blood test could predict the onset of tuberculosis three to six months before people become unwell, a finding which could help better target antibiotics and save countless lives.
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    New study is the first to use machine learning to project migration patterns resulting from sea-level rise. Researchers found the impact of rising oceans will ripple across the country, beyond coastal areas at risk of flooding, as affected people move inland. Popular relocation choices will include land-locked cities such as Atlanta, Houston, Dallas, Denver and […]
  • Acousto-optic modulation of photonic bound state in the continuum January 22, 2020
    Applying bound states in the continuum (BICs) in photonic integrated circuits enables low-loss light guidance and routing in low-refractive-index waveguides on high-refractive-index substrates. Here, we demonstrate high-quality integrated lithium niobate microcavities with circulating BICs and further acousto-optically modulate these BICs by surface acoustic waves. The acousto-optic coupling is well situated in the resolved-sideband regime, which […]
  • Ben-Gurion University researchers slash pre-drug screening time from years to days January 22, 2020
    'Our new approach will increase the understanding of the mechanisms and evolutionary origins of specific PPIs, and facilitate the rational design of specific inhibitors that can discriminate between structurally similar protein targets,' says Professor Niv Papo of BGU's Avram and Stella Goldstein-Goren Department of Biotechnology Engineering and the National Institute for Biotechnology in the Negev […]
  • Even after death, animals are important in ecosystems January 22, 2020
    Animal carcasses play an important role in biodiversity and ecosystem functioning. Scientists from the German Centre for Integrative Biodiversity Research (iDiv) and the University of Groningen have published these findings in PLOS ONE. Carcasses not only provide food for carrion-eating animals. Their nutrients also increase the growth of surrounding plants, which attracts many herbivorous insects […]
  • Study shines light on spread of Candida auris January 22, 2020
    Candida auris is capable of forming high burden biofilms, which may help explain why this fungal pathogen is spreading in hospitals worldwide, according to a study published this week in mSphere, an open-access journal of the American Society for Microbiology. The research also establishes a new model to investigate the spread of this emerging fungal […]
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