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Is there a heightened risk of heart failure with diabetes medications containing saxagliptin and alogliptin?

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April o5, 2016 – There have been indications that a heightened risk of heart failure may be associated with diabetes medications containing the pharmacologically active ingredients saxagliptin or alogliptin.  In the US, this includes  the FDA-approved drugs Saxagliptin (Onglyza), Saxagliptin/Metformin (Kombiglyze XR), Alogliptin (Nesina), Alogliptin/Metformin (Kazano), and Alogliptin/Pioglitazone (Oseni).

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Drug Safety Communication: DPP-4 inhibitors for Type 2-Diabetes may cause severe joint pain

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August 29, 2015 – This may after all not be so good news for Type 2-Diabetes patients on DPP-4 inhibitor medications. The American Food and Drug Administration (FDA) is warning that the type 2 diabetes medicines containing the pharmacologically active ingredients (PAI) sitagliptin, saxagliptin, linagliptin, and alogliptin may cause joint pain that can be severe and disabling.  

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