Blog Archives

Dépakine: Les petits-enfants touchés eux aussi?

22 novembre 2018 –  “Au bout du 149e cas, je me suis dit qu’il y avait trop de malchance pour que ce soit un hasard”, relate Marine Martin, présidente de l’association des victimes de la Dépakine (Apesac). Depuis 2014, la lanceuse d’alerte a constaté certains troubles majeurs chez de nombreux enfants de victimes de la Dépakine.

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Enfin: Le valproate est interdit pendant la grossesse

17 juin 2018 – Venant de l’Agence nationale de sécurité du médicament et des produits de santé (ANSM), on apprend que le valproate est finalement interdit pendant la grossesse et ne doit plus être prescrit aux filles, adolescentes et femmes en âge de procréer (sauf circonstances exceptionnelles).

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Enfin: Contre-indication des médicaments à base de valproate

09 juillet 2017 – Les autorités françaises viennent de prendre cette mesure attendue depuis longtemps et contre-induite médicaments contenant du valproate pour les femmes enceintes et les femmes en âge de procréer. Cela devrait laisser tombé gravement, au moins en France, le nombre d’enfants nés avec des malformations congénitales tératogènes après le traitement des mères avec des valproates.

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Valproate et dérivés : renforcement de l’information sur les risques

02 mars 2017 – Ce message vient de L’Agence nationale de sécurité du médicament et des produits de santé de la France  (l’ANSM) et se reflète dans leur formulation:

A partir du 1er mars 2017, un pictogramme alertant sur les dangers de la prise de médicaments contenant du valproate ou un dérivé pendant la grossesse (Dépakine,

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  • Mapping genetic variants driving toxicity to leukemia therapy février 25, 2020
    Scientists at St. Jude Children's Research Hospital, alongside collaborators around the world, have created a comprehensive reference of functional variants in an important drug-metabolizing enzyme called NUDT15. This thorough understanding of NUDT15 variants provides an invaluable resource for predicting which patients being treated with thiopurine drugs for acute lymphoblastic leukemia (ALL) are likely to experience […]
  • Releasing brakes: Potential new methods for Duchenne muscular dystrophy therapies février 24, 2020
    Researchers identified a group of small molecules that may open the door to developing new therapies for Duchenne muscular dystrophy (DMD), an as-yet-uncured disease that results in devastating muscle weakening and loss. The molecules tested by the team from the Perelman School of Medicine at the University of Pennsylvania eased repression of a specific gene, […]
  • Extra chromosomes in cancers can be good or bad février 24, 2020
    Cancer cells are notorious for their genetic disarray. A tumor cell can contain an abundance of DNA mutations and most have the wrong number of chromosomes. A missing or extra copy of a single chromosome creates an imbalance called aneuploidy, which can skew the activity of hundreds or thousands of genes. As cancer progresses, so […]
  • Researchers show that DNA topological problems may cause lymphoma février 24, 2020
    Researchers from the Spanish National Cancer Research Centre (CNIO), Madrid, and the Andalusian Molecular Biology and Regenerative Medicine Centre (Cabimer), Seville, published a paper in Nature Communications that shows that DNA topological problems may cause endogenous DNA breaks that have a causal relationship with cancer.
  • New DNA test that reveals a child's 'true age' has promise, but ethical pitfalls février 24, 2020
    Epigenetic clocks are a new type of biological test currently capturing the attention of the scientific community, private companies and governmental agencies because of their potential to reveal an individual's "true" age.
  • Regular walnut consumption linked to health and longevity in women, according to new study février 25, 2020
    According to a new epidemiological study, women in their late 50s and early 60s who consumed at least two servings of walnuts per week had a greater likelihood of healthy aging compared to those who did not eat walnuts. After accounting for various factors that could impact health in older adults, such as education and […]
  • Cynicism and disrespect: A vicious cycle février 25, 2020
    An international study with data from Europe and the USA has found that disrespectful treatment leads to cynical beliefs about human nature. These cynical beliefs, in turn, again lead to disrespectful treatment.
  • New study shows significant increase in weight after breast cancer février 25, 2020
    New study findings suggest that weight gain after breast cancer is a greater problem than previously thought. The first national survey on weight after breast cancer in Australia, published in BMC Cancer journal, found close to two-thirds (63.7%) of women reported weight gain at an average of nine kilograms after a breast cancer diagnosis, and […]
  • Study finds gender disparities in hematology research success février 25, 2020
    Hematologists who complete a mentored training program experience greater levels of academic success than those who do not; however, a study published today in Blood Advances suggests a slight discrepancy in success levels between male and female hematologists.
  • NUS-led study suggests mangrove forests provide cause for conservation optimism, for now février 25, 2020
    An international team of researchers led by Associate Professor Daniel Friess and Dr Erik Yando of the National University of Singapore has found that globally, mangrove loss rates have reduced by almost an order of magnitude between the late 20th and early 21st century -- from what was previously estimated at one to three per […]
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