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Information über potentielle Wechselwirkungen von Protonen-Pumpen-Inhibitoren (PPI’s) mit Clopidogrel-haltigen Arzneimitteln

7. Dezember 2009 – Sanofi Pharma Bristol-Myers Squibb informiert in Übereinstimmung mit dem Deutschen Bundesinstitut für Arzneimittel und Medizinalprodukte (BfArM) darüber, dass die Europäische Fachinformation (Summary of Product Characteristics, SPC) für Clopidogrel-Hydrogensulfat, in Verkehr gebracht als Plavix®, überarbeitet worden ist.

Danach wird in die SPC ein Warnhinweis aufgenommen,

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  • Artificial RNA editing with ADAR for gene therapy July 9, 2020
    Many of the diseases caused by point mutations have no established therapeutic approaches. Prof. Tsukahara and colleagues (Japan Advanced Institute of Science and Technology) are studying a therapeutic method using artificial RNA editing. Artificial site-directed RNA editing is an important technique for modifying genes and ultimately regulating protein function. We are trying to modify the […]
  • Amygdala changes in male patients with schizophrenia and bipolar disorder July 9, 2020
    Researchers at Kumamoto University, Japan have revealed that DNA methylation occurs in the gene that codes serotonin transporter (SERT), a protein that regulates neurotransmitter transmission, in schizophrenia and bipolar patients. Particularly prominent in males and patients with certain genetic polymorphisms, this methylation is inversely correlated with volume of the amygdala in the brain. This work […]
  • Surprisingly many peculiar long introns found in brain genes July 9, 2020
    In a recent study of genes involved in brain functioning, their previously unknown features have been uncovered by bioinformaticians from the Moscow Institute of Physics and Technology and the Institute of Mathematical Problems of Biology, RAS. The findings are reported in PLOS One.
  • Major cause of rare genetic mitochondrial disease identified July 9, 2020
    A cutting-edge study from the Murdoch Children's Research Institute (MCRI) has given hope to families of children born with a fatal heart muscle disease caused by faulty cell machinery.
  • Spatial mapping method pinpoints potential new therapeutic targets in lupus July 8, 2020
    A team of researchers from Children's Hospital of Philadelphia (CHOP) used a new method of pinpointing potential disease-causing changes in the genome to identify two new potential therapeutic targets for lupus, while also paving the way for more accurately identifying disease-causing variations in other autoimmune disorders. The findings were published online in Nature Communications.
  • Jurassic fossils from northeastern China reveal morphological stasis in the catkin-yew July 11, 2020
    Dong and colleagues studied well-preserved plant fossils from the Middle-Late Jurassic Daohugou Bed in eastern Inner Mongolia, northeastern China. These fossils closely resemble the extant catkin-yews Amentotaxus. They provide unequivocal evidence that the catkin-yews have undergone little morphological change over at least ~160 million years. Like ginkgo, the catkin-yews are living fossils that provide an […]
  • Largest study of prostate cancer genomics in Black Americans ids targets for therapies July 10, 2020
    Black men in the United States are known to suffer disproportionately from prostate cancer, but few studies have investigated whether genetic differences in prostate tumors could have anything to do with these health disparities. Now, in the largest study of its kind to date, researchers from Boston University School of Medicine (BUSM), UC San Francisco […]
  • Liquid metal synthesis for better piezoelectrics: Atomically-thin tin-monosulfide July 10, 2020
    An RMIT-UNSW collaboration applies liquid-metal synthesis to piezoelectrics, advancing future flexible, wearable electronics, and biosensors drawing their power from the body's movements.Piezoelectric materials such as atomically-thin tin-monosulfide (SnS) convert mechanical forces or movement into electrical energy. Along with their inherent flexibility, this makes them candidates for flexible nanogenerators in wearable electronics or internal, self-powered biosensors.
  • Mom and baby share 'good bacteria' through breast milk July 10, 2020
    A new study by researchers at the University of British Columbia and the University of Manitoba has found that bacteria are shared and possibly transferred from a mother's milk to her infant's gut, and that breastfeeding directly at the breast best supports this process.
  • Alaskan volcano linked to mysterious period with extreme climate in ancient Rome July 10, 2020
    The cold, famine and unrest in ancient Rome and Egypt after the assassination of Julius Caesar in 44 BCE has long been shrouded in mystery. Now, an international team, including researchers from the University of Copenhagen, has found evidence suggesting that the megaeruption of an Alaskan volcano may be to blame.
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