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Ein Wort zu Valsartan, weiteren Sartanen, und deren Verunreinigungen

3. Februar 2019 – Blutdrucksenkende Arzneimittel welche die Wirkstoffe Valsartan, Candesartan, Irbesartan, Losartan, oder Olmesartan enthalten, sind in den vergangenen Monaten zunehmend in die Kritik geraten, da in verschiedensten Chargen dieser Arzneimittel nitrosaminhaltige Verunreinigungen wie N-Nitrosodimethylamin (NDMA) und N-Nitrosodiethylamin (NDEA), die von der WHO als wahrscheinliche menschliche Karzinogene eingestuft werden,

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Auch in der Schweiz: Valsartan ohne Ende

04. Dezember 2018 – Im Verlaufe dieses Sommers wurde bekannt, dass in der Europäischen Union (EU), in den USA, in Kanada, und anderen Ländern in Arzneimitteln, welche zur Therapie der Hypertonie (hohem Blutdruck) eingesetzt werden, und welche den Wirkstoff Valsartan enthalten, aus der Synthese des Valsartans stammende Verunreinigungen mit dem beim Menschen krebserregenden N-Nitrosodimethylamin (NDMA) sowie,

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  • Releasing brakes: Potential new methods for Duchenne muscular dystrophy therapies February 24, 2020
    Researchers identified a group of small molecules that may open the door to developing new therapies for Duchenne muscular dystrophy (DMD), an as-yet-uncured disease that results in devastating muscle weakening and loss. The molecules tested by the team from the Perelman School of Medicine at the University of Pennsylvania eased repression of a specific gene, […]
  • Extra chromosomes in cancers can be good or bad February 24, 2020
    Cancer cells are notorious for their genetic disarray. A tumor cell can contain an abundance of DNA mutations and most have the wrong number of chromosomes. A missing or extra copy of a single chromosome creates an imbalance called aneuploidy, which can skew the activity of hundreds or thousands of genes. As cancer progresses, so […]
  • Researchers show that DNA topological problems may cause lymphoma February 24, 2020
    Researchers from the Spanish National Cancer Research Centre (CNIO), Madrid, and the Andalusian Molecular Biology and Regenerative Medicine Centre (Cabimer), Seville, published a paper in Nature Communications that shows that DNA topological problems may cause endogenous DNA breaks that have a causal relationship with cancer.
  • New DNA test that reveals a child's 'true age' has promise, but ethical pitfalls February 24, 2020
    Epigenetic clocks are a new type of biological test currently capturing the attention of the scientific community, private companies and governmental agencies because of their potential to reveal an individual's "true" age.
  • Mayo researchers recommend all women with breast cancer diagnosis under age 66 be offered genetic testing February 21, 2020
    A study by researchers at Mayo Clinic published this week in the Journal of Clinical Oncology suggests that all women with a breast cancer diagnosis under the age of 66 be offered germline genetic testing to determine if they have a gene mutation known to increase the risk of developing other cancers and cancers among […]
  • An 'exceptionally stable' single-atom catalyst February 24, 2020
    Scientists at Tokyo Institute of Technology (Tokyo Tech) have shown that single platinum atoms trapped in C12A7 crystals act as a stable and effective catalyst for the hydrogenation of nitroarenes, an essential process in the production of many kinds of fine chemicals. Their approach could become a versatile route for developing other single-atom catalysts for […]
  • Researchers analyze influenza epidemiologic supervision and children cases in Catalonia February 24, 2020
    Two studies led by the UB analyzed several aspects involved in the detection of the influenza: the utility of the definition of the illness considering clinical manifestation and complementarity of supervision systems based on severe ambulatory cases that require hospitalization in Catalonia. Moreover, they also studied the features of the cases that were detected in […]
  • Short film of a magnetic nano-vortex February 24, 2020
    For the first time, researchers at the Paul Scherrer Institute PSI have recorded a '3D film' of magnetic processes on the nanometer scale. This reveals a variety of dynamics inside the material, including the motion of swirling boundaries between different magnetic domains. The insights were gained with a method newly developed at the Swiss Light […]
  • Neural cells speed up function in 3D bioprinted skeletal muscle constructs February 24, 2020
    Wake Forest Institute for Regenerative Medicine scientists improve on 3D bioprinting research by investigating the effects of neural cell integration into bioprinted muscle constructs to accelerate functional muscle regeneration.
  • Mirrored chip could enable handheld dark-field microscopes February 24, 2020
    Engineers at MIT have developed a small, mirrored chip that helps to produce dark-field images, without dedicated expensive components. The chip is slightly larger than a postage stamp and as thin as a credit card. When placed on a microscope's stage, the chip emits a hollow cone of light that can be used to generate […]
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