Blog Archives

Increased Risk Of Aneurysms And Artery Dissections With VEGF Inhibitors

August 26 2020 –  Vascular endothelial growth factor (VEGF), originally known as vascular permeability factor (VPF)  is a signal protein produced by cells that stimulates the formation of blood vessels. VEGF is a sub-family of growth factors, the platelet-derived growth factor family of cystine-knot growth factors.

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Therapies that promote progressive multifocal leukoencephalopathy (PML)

August 23, 2019 – Progressive multifocal leukoencephalopathy (PML) is a rare and often fatal viral disease characterized by progressive damage or inflammation of the white matter of the brain at multiple locations (i.e., multifocal). It is caused by the JC virus,

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Sunitinib [Sutent] und Bevacizumab [Avastin]: Kiefer-Osteonekrosen bei gleichzeitiger oder früherer Therapie mit Bisphosphonat-haltigen Arzneimitteln

24. Dezember 2010 – Swissmedic macht uns folgende Information zugänglich (Text durch den Blog-Author leicht adaptiert):

Die beiden Präparate Sunitinib [Sutent] und Bevacizumab [Avastin] sind für die Behandlung bestimmter fortgeschrittener Krebserkrankungen zugelassen und haben Wirkungen auf die Tumor-Gefässbildung und damit auf die Versorgung des Tumorgewebes mit Nährstoffen und Sauerstoff.

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Bevacizumab [Avastin]: Process for Removal of Breast Cancer Indication Begun Because of Lack of Efficacy

December 16, 2010  –  Today, the American Food and Drug Administration notified healthcare professionals and patients that it is recommending removing the breast cancer indication for Bevacizumab [Avastin] because the drug has not been shown to be safe and effective for that use. The drug itself is not being removed from the market and today’s action will not have any immediate impact on its use in treating breast cancer.

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  • Silencing gene expression to cure complex diseases October 26, 2020
    Many people think of new medicines as bullets, and in the pharmaceutical industry, frequently used terms like "targets" and "hits" reinforce that idea. Immuneering co-founder and CEO Ben Zeskind '03, Ph.D. '06 prefers a different analogy.
  • Bits of genetic material called microRNAs may drive metabolic disorders October 26, 2020
    In a study published today in the journal Cell, UC Berkeley Nutritional Sciences and Toxicology professor Anders Näär led a group of researchers from 12 institutions in the United States and Europe, to better understand a region on the second human chromosome previously linked to both the digestion of milk and metabolic disorders. They discovered […]
  • New York City's coronavirus outbreak spread from more European sources than first reported October 26, 2020
    The COVID-19 pandemic started earlier than previously thought in New York City and Long Island by dozens of people infected mostly with strains from Europe. A new analysis also shows that most of the spread was within the community, as opposed to coming from people who had traveled.
  • Cause of Alzheimer's disease traced to mutation in common enzyme October 26, 2020
    Researchers from Tokyo Metropolitan University have discovered a new mechanism by which clumps of tau protein are created in the brain, killing brain cells and causing Alzheimer's disease. A specific mutation to an enzyme called MARK4 changed the properties of tau, usually an important part of the skeletal structure of cells, making it more likely […]
  • Researchers uncover crucial gene for growth of Ewing sarcoma October 23, 2020
    Researchers at the Institut de Recerca Sant Joan de Déu (IRSJD) in collaboration with those at Center for Genomic Regulation (CRG) have discovered that RING1B is a critical gene for the development of Ewing sarcoma, a rare type of developmental cancer that presents in bones and soft tissues. This newly uncovered epigenetic vulnerability in Ewing […]
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