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Heart attacks and stroke: The risk of DPP-4 anti-diabetes drugs

May 06, 2018 – In April 2016 the American Food and Drug Administration (FDA) took regulatory action by mandating label changes with new warnings about an increased risk of heart failure for  new diabetes medicines in the dipeptidyl peptidase-4 (DPP-4) inhibitor drug class, including Saxagliptin (Onglyza),

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Diabetes: Is rhabdomyolysis associated with DPP-IV inhibitors?

October 15, 2017 – According to the quarterly safety report April – June 2017 by the American Food & Drug Administration (FDA), originating from the  FDA Adverse Event Reporting System (FAERS), the class of diabetes drugs referred to as dipeptidyl peptidase-4 inhibitors (DPP-IV inhibitors) may be associated with rhabdomyolysis,

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Is there a heightened risk of heart failure with diabetes medications containing saxagliptin and alogliptin?

April o5, 2016 – There have been indications that a heightened risk of heart failure may be associated with diabetes medications containing the pharmacologically active ingredients saxagliptin or alogliptin.  In the US, this includes  the FDA-approved drugs Saxagliptin (Onglyza), Saxagliptin/Metformin (Kombiglyze XR), Alogliptin (Nesina), Alogliptin/Metformin (Kazano), and Alogliptin/Pioglitazone (Oseni).

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  • Study reveals restoration of retinal and visual function following gene therapy October 19, 2020
    A breakthrough study, led by researchers from the University of California, Irvine, results in the restoration of retinal and visual functions of mice models suffering from inherited retinal disease.
  • Scientists map the human proteome October 19, 2020
    Twenty years after the release of the human genome, the genetic "blueprint" of human life, an international research team, including the University of British Columbia's Chris Overall, has now mapped the first draft sequence of the human proteome.
  • The line of succession in neuron function October 19, 2020
    A specific region of messenger RNAs, the 3' untranslated region (3'UTR), plays an important role for cells to function properly. During embryonic development, 3'UTRs in hundreds of RNAs lengthen exclusively in neurons, which is crucial for the cells of the brain to function properly. The lab of Valérie Hilgers at the Max Planck Institute of […]
  • Pinpointing the 'silent' mutations that gave the coronavirus an evolutionary edge October 16, 2020
    We know that the coronavirus behind the COVID-19 crisis lived harmlessly in bats and other wildlife before it jumped the species barrier and spilled over to humans.
  • Transposons could be rewiring our brains October 16, 2020
    A new study by neuroscientists at the University of Oxford shows that mobile genetic elements that were active in the genomes of our ancestors could be closely linked to important functions in our brain and might help diversify our behavior, cognition and emotions.
  • Asymmetric optical camouflage: Tuneable reflective color accompanied by optical Janus effect October 20, 2020
    Deliverying viewing-direction sensitive information display across single sheet of transreflective window is introduced. Based on the experimental verification of theoretical modelling, scientists in Republic of Korea invented colour tuneable optical device that displays different colours and messages depending on viewing direction which is completely new and exotic optical phenomenon. A step further, they realized asymmetric […]
  • Researchers at the forefront of developing machine learning methods for chemical discovery October 20, 2020
    Prof. Alexandre Tkatchenko and his research team at the University of Luxembourg have been awarded grants totalling 500,000 euros to conduct research in the emerging field of machine learning methods for chemical discoveries.
  • COVID-19: Distancing and masks are not enough October 20, 2020
    Decades-old data is being used to describe the propagation of tiny droplets. Now a fluid dynamics team has developed new models: Masks and distancing are good, but not enough. Even with a mask, infectious droplets can be transmitted over several meters and remain in the air longer than previously thought.
  • Oncotarget: Inhibition of HAS2 and hyaluronic acid production by 1,25-Dihydroxyvitamin D3 in breast October 20, 2020
    Oncotarget Volume 11, Issue 30 reported that genomic profiling of murine mammary tumor cells with differential VDR expression identified 35 transcripts that were altered by the 1,25D3-VDR complex including Hyaluronan Synthase-2.
  • US adults' likelihood of accepting COVID-19 vaccination October 20, 2020
    In this survey study of U.S. adults, vaccine-related attributes and political characteristics were associated with self-reported preferences for choosing a hypothetical COVID-19 vaccine and self- reported willingness to receive vaccination. These results may help inform public health campaigns to address vaccine hesitancy when a COVID-19 vaccine becomes available.
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