March 23, 2017 – For sure across the United States, but by a fair assumption worldwide also, late-onset Alzheimer’s disease (AD) is the most common form of dementia. There is a strong need for in vivo markers for AD risk stratification …

Polygenic hazard scores in age-associated Alzheimer’s disease Read more »

March 10, 2017 – A new gene that can lead to sudden death among young people and athletes has now been identified by an international team of researchers. The gene, called CDH2, causes arrhythmogenic right ventricle cardiomyopathy (ARVC), which is …

CDH2 gene to cause sudden death in young people Read more »

  February 08, 2017 – Genetic predisposition may go in both ways, the positive and the negative. Usually, when we talk about genetic predisposition, there is an immediate association with some unwanted reactions of individuals towards drugs (e.g., abacavir-induced hypersensitivity …

Genetic predisposition and sweating: Most Koreans don’t have to wear deodorants Read more »

Sacco K, Grech G EPMA J 2015;6(1):15 PMID: 26203310 Abstract Breast cancer is a heterogeneous disease that necessitates proper patient classification to direct surgery, pharmacotherapy, and radiotherapy. Despite patients within the same subgroup receiving similar pharmacotherapy, substantial variation in clinical …

Actionable pharmacogenetic markers for prediction and prognosis in breast cancer Read more »

October 17, 2013 – This morning, while commuting (a one and a half hour train ride) not only was I noticing all those stoned and negatively charged early morning faces of my fellow commuters but I also stumbled upon the …

The deletion variant of the ADRA2B gene and the genetic predisposition to focus on the negative Read more »

April 23, 2011 – In the history of flawed and/or market-withdrawn drugs, Lumiracoxib [Joicela], formely known as [Prexige], may only be a footnote, hardly comparable to the attention received by the high flying but ill-fated Rofecoxib [Vioxx], Troglitazone [Rezulin], and …

Could a biomarker rescue Lumiracoxib [Joicela], formerly known as [Prexige]? A genome-wide study identifies a strong assossiation of the HLA allele DQA1*0102 with Lumiracoxib [Joicela]-related serious liver injury Read more »